Results 31 to 40 of about 71,946 (261)

Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis

BMC Microbiology, 2010
Background Mycobacteria use inositol in phosphatidylinositol, for anchoring lipoarabinomannan (LAM), lipomannan (LM) and phosphatidylinosotol mannosides (PIMs) in the cell envelope, and for the production of mycothiol, which maintains the redox balance ...
Parish Tanya, Av-Gay Yossef, Dinadayala Premkumar, Wheeler Paul R, Movahedzadeh Farahnaz, Daffé Mamadou, Stoker Neil G   +6 more
doaj   +1 more source

Effect of Fiber Fermentation and Protein Digestion Kinetics on Mineral Digestion in Pigs

Animals, 2022
Nutrient kinetic data and the timing of nutrient release along the gastrointestinal tract (GIT), are not yet widely used in current feed formulations for pigs and poultry.
Charlotte M. E. Heyer, Neil W. Jaworski, Greg I. Page, Ruurd T. Zijlstra   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi

mBio
Inositol phosphates are involved in a myriad of biological roles and activities such as Ca2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity.
Mayara S. Bertolini, Sabrina E. Cline, Miguel A. Chiurillo, Brian S. Mantilla, Aharon Eidex, Logan P. Crowe, Danye Qiu, Henning J. Jessen, Adolfo Saiardi, Roberto Docampo   +9 more
doaj   +1 more source

Comparative Genomics of Pneumocystis Species Suggests the Absence of Genes for myo-Inositol Synthesis and Reliance on Inositol Transport and Metabolism

mBio, 2014
In the context of deciphering the metabolic strategies of the obligate pathogenic fungi in the genus Pneumocystis, the genomes of three species (P. carinii, P. murina, and P.
Aleksey Porollo, Thomas M. Sesterhenn, Margaret S. Collins, Jeffrey A. Welge, Melanie T. Cushion   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Overexpression of MdMIPS1 enhances drought tolerance and water-use efficiency in apple

Journal of Integrative Agriculture, 2022
Myo-inositol and its derivatives play important roles in the tolerance of higher plants to abiotic stresses, and myo-inositol-1-phosphate synthase (MIPS) is the rate-limiting enzyme in myo-inositol biosynthesis. In this study, we found that increased myo-
Ling-yu HU, Hong YUE, Jing-yun ZHANG, Yang-tian-su LI, Xiao-qing GONG, Kun ZHOU, Feng-wang MA   +6 more
doaj   +1 more source

Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis [PDF]

Molecules, 2020
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including ulcerative colitis and Crohn’s disease.
Samuel E. Weinberg, Le Yu Sun, Allison L. Yang, Jie Liao, Guang Yu Yang   +4 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis

BMC Biology, 2021
Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla, Mandeep Kaur, Swati Kanwar, Gazaldeep Kaur, Shivani Sharma, Shubhra Ganguli, Vandana Kumari, Koushik Mazumder, Pratima Pandey, Hatem Rouached, Vikas Rishi, Rashna Bhandari, Ajay Kumar Pandey   +12 more
doaj   +1 more source