Results 41 to 50 of about 38,827 (170)

Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae. [PDF]

Biochem J, 2015
Ribosome biogenesis is an essential cellular process regulated by the metabolic state of a cell. We examined whether inositol pyrophosphates, energy-rich derivatives of inositol that act as metabolic messengers, play a role in ribosome synthesis in the ...
Thota SG, Unnikannan CP, Thampatty SR, Manorama R, Bhandari R.   +4 more
europepmc   +2 more sources

Structural insight into inositol pyrophosphate turnover [PDF]

Advances in Biological Regulation, 2013
The diphosphoinositol polyphosphates ("inositol pyrophosphates"; PP-InsPs) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, insulin signaling and neutrophil activation.
Stephen B, Shears, Jeremy D, Weaver, Huanchen, Wang   +2 more
openaire   +2 more sources

Versatile signaling mechanisms of inositol pyrophosphates

Current Opinion in Chemical Biology, 2022
Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules ...
Minh Nguyen Trung, David Furkert, Dorothea Fiedler   +2 more
openaire   +2 more sources

Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression

mBio, 2022
Inositol pyrophosphates (IPPs) are signaling molecules that regulate cellular phosphate homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1,5-IP8 derepress the PHO regulon while mutations that ablate IP8 synthesis are PHO ...
Bradley Benjamin, Angad Garg, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman   +5 more
doaj   +1 more source

Inositol pyrophosphates regulate endocytic trafficking [PDF]

Proceedings of the National Academy of Sciences, 2002
The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established.
Adolfo, Saiardi, Catherine, Sciambi, J Michael, McCaffery, Beverly, Wendland, Solomon H, Snyder   +4 more
openaire   +2 more sources

Understanding the Catabolism of Inositol Pyrophosphates in Plants

Inositol pyrophosphates (PP-InsPs) are vital nutrient messengers that finely regulate plant phosphate homeostasis, vital for growth and development. The enzyme VIP1, member of the PPIP5K kinase family, central to this network, generates the key signaling molecule 1,5-InsP8 and also participates in its breakdown. Alongside VIP1, Plant and Fungi Atypical
Laurent, Florian
openaire   +2 more sources

Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity. [PDF]

PLoS ONE, 2017
Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important
Michael Wormald, Gangling Liao, Martha Kimos, James Barrow, Huijun Wei   +4 more
doaj   +1 more source

Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase

mBio, 2023
Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez, Beate Schwer, Nikolaus Jork, Henning J. Jessen, Stewart Shuman   +4 more
doaj   +1 more source

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry [PDF]

, 2021
Inositol pyrophosphates (PP-InsPs) are an important group of intracellular signaling molecules. Derived from inositol phosphates (InsPs), these molecules feature the presence of at least one energetic pyrophosphate moiety on the myo-inositol ring.
Jessen, HJ, Saiardi, A, Qiu, D, Eisenbeis, VB   +3 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues. [PDF]

FEBS Lett
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Seaton-Terry A, Cutright AJ, Loi MNC, Martin J, Gilligan JW, Kubina JN, Arambula MJ, Palmu ST, Zhou D, Blind RD.   +9 more
europepmc   +2 more sources