Results 41 to 50 of about 903 (153)

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate [PDF]

Proceedings of the National Academy of Sciences, 2001
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK).
A, Saiardi, E, Nagata, H R, Luo, A, Sawa, X, Luo, A M, Snowman, S H, Snyder   +6 more
openaire   +2 more sources

The inositol pyrophosphate pathway in health and diseases [PDF]

Biological Reviews, 2017
ABSTRACTInositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs ...
openaire   +2 more sources

Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo

Nature Communications, 2016
Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far.
Igor Pavlovic, Divyeshsinh T. Thakor, Jessica R. Vargas, Colin J. McKinlay, Sebastian Hauke, Philipp Anstaett, Rafael C. Camuña, Laurent Bigler, Gilles Gasser, Carsten Schultz, Paul A. Wender, Henning J. Jessen   +11 more
doaj   +1 more source

Correction: Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. [PDF]

PLoS Pathogens, 2014
doaj   +5 more sources

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi

mBio
Inositol phosphates are involved in a myriad of biological roles and activities such as Ca2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity.
Mayara S. Bertolini, Sabrina E. Cline, Miguel A. Chiurillo, Brian S. Mantilla, Aharon Eidex, Logan P. Crowe, Danye Qiu, Henning J. Jessen, Adolfo Saiardi, Roberto Docampo   +9 more
doaj   +1 more source

Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes.

PLoS Genetics, 2018
Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required for virulence in pathogenic fungi and provides an informative model of stress ...
Kaitlyn L Norman, Christian A Shively, Amberlene J De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J Cullen, Anuj Kumar   +6 more
doaj   +1 more source

Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis

Molecules, 2020
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including
Samuel E. Weinberg, Le Yu Sun, Allison L. Yang, Jie Liao, Guang Yu Yang   +4 more
doaj   +1 more source

Inositol pyrophosphates: structure, enzymology and function. [PDF]

Cell Mol Life Sci, 2009
The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the ...
Barker CJ, Illies C, Gaboardi GC, Berggren PO.   +3 more
europepmc   +3 more sources

Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders

Biomolecules
Inositol is a vital sugar molecule involved in numerous signaling pathways required for cellular homeostasis and cell survival. Myo-inositol and its phospho-derivatives, inositol phosphates (IPs), are the most prevalent forms of inositol found in living ...
Chisom J. Onu, Michael Adu, Mohamed Chakkour, Vikalp Kumar, Miriam L. Greenberg   +4 more
doaj   +1 more source

Role of transporters in regulating mammalian intracellular inorganic phosphate

Frontiers in Pharmacology, 2023
This review summarizes the current understanding of the role of plasma membrane transporters in regulating intracellular inorganic phosphate ([Pi]In) in mammals. Pi influx is mediated by SLC34 and SLC20 Na+-Pi cotransporters.
Michael L. Jennings
doaj   +1 more source