Results 41 to 50 of about 751 (180)
How inositol pyrophosphates control cellular phosphate homeostasis? [PDF]
, 2012 Phosphorus in his phosphate PO(4)(3-) configuration is an essential constituent of all life forms. Phosphate diesters are at the core of nucleic acid structure, while phosphate monoester transmits information under the control of protein kinases and ...
Saiardi, Adolfo, Saiardi, A
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Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity. [PDF]
PLoS ONE, 2017 Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important
Michael Wormald +4 more
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mBio, 2023 Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez +4 more
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, 2021 Inositol pyrophosphates are an important class of second messengers that recently became an important point of cell signaling due to their presence and abundance in eukaryotic cells.
Bittner, Tamara
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Role of Inositols and Inositol Phosphates in Energy Metabolism
Molecules, 2020 Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree +4 more
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Nature Communications, 2020 Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitation ...
Danye Qiu +14 more
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Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism [PDF]
Fungal Genetics and Biology, 2018 Cryptococcus neoformans is the most common cause of deadly fungal meningitis. This fungus has a complex inositol acquisition and utilization system, and our previous studies have shown the importance of inositol utilization in cryptococcal development and virulence. However, how inositol utilization is regulated in this fungus remains unknown.
Guojian, Liao +7 more
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Data in Brief, 2016 Inositol pyrophosphates are cellular signals that are created by the actions of inositol kinases and are degraded by highly active inositol phosphatases.
Gayane Machkalyan +4 more
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Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules [PDF]
, 2017 Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in addition to monophosphates.
Sen, Jayraj +7 more
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The inositol pyrophosphate pathway in health and diseases [PDF]
Biological Reviews, 2017 ABSTRACTInositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs ...
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