Results 51 to 60 of about 38,827 (170)

Role of Inositols and Inositol Phosphates in Energy Metabolism

Molecules, 2020
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree, Nanthaphop Thongmaen, Kwanchanit Tantivejkul, Chantacha Sitticharoon, Ivana Vucenik   +4 more
doaj   +1 more source

Mass spectrometry analysis of PPIP5K1 interactions and data on cell motility of PPIP5K1-deficient cells

Data in Brief, 2016
Inositol pyrophosphates are cellular signals that are created by the actions of inositol kinases and are degraded by highly active inositol phosphatases.
Gayane Machkalyan, Phan Trieu, Darlaine Pétrin, Terence E. Hébert, Gregory J. Miller   +4 more
doaj   +1 more source

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

Nature Communications, 2020
Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitation ...
Danye Qiu, Miranda S. Wilson, Verena B. Eisenbeis, Robert K. Harmel, Esther Riemer, Thomas M. Haas, Christopher Wittwer, Nikolaus Jork, Chunfang Gu, Stephen B. Shears, Gabriel Schaaf, Bernd Kammerer, Dorothea Fiedler, Adolfo Saiardi, Henning J. Jessen   +14 more
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The inositol pyrophosphate pathway in health and diseases [PDF]

Biological Reviews, 2017
ABSTRACTInositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs ...
openaire   +2 more sources

Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism [PDF]

Fungal Genetics and Biology, 2018
Cryptococcus neoformans is the most common cause of deadly fungal meningitis. This fungus has a complex inositol acquisition and utilization system, and our previous studies have shown the importance of inositol utilization in cryptococcal development and virulence. However, how inositol utilization is regulated in this fungus remains unknown.
Guojian, Liao, Yina, Wang, Tong-Bao, Liu, Gurkirat, Kohli, Weidong, Qian, Erika, Shor, Selvakumar, Subbian, Chaoyang, Xue   +7 more
openaire   +2 more sources

Assigning the Absolute Configuration of Inositol Poly- and Pyrophosphates by NMR Using a Single Chiral Solvating Agent

Biomolecules, 2023
Inositol phosphates constitute a family of highly charged messenger molecules that play diverse roles in cellular processes. The various phosphorylation patterns they exhibit give rise to a vast array of different compounds.
Kevin Ritter, Nikolaus Jork, Anne-Sophie Unmüßig, Maja Köhn, Henning J. Jessen   +4 more
doaj   +1 more source

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate [PDF]

Proceedings of the National Academy of Sciences, 2001
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK).
A, Saiardi, E, Nagata, H R, Luo, A, Sawa, X, Luo, A M, Snowman, S H, Snyder   +6 more
openaire   +2 more sources

Novel shades of inositol pyrophosphates – in vitro and in cellulo evaluation of inositol pyrophosphate probes

, 2021
Inositol pyrophosphates are an important class of second messengers that recently became an important point of cell signaling due to their presence and abundance in eukaryotic cells.
Bittner, Tamara
core   +1 more source

Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae [PDF]

, 2013
Several studies have demonstrated the activation of phosphoinositide-specific phospholipase C (Plc) in nuclei of mammalian cells during synchronous progression through the cell cycle, but the downstream targets of Plc-generated inositol 1,4,5 ...
York, John D., Bedalov, Antonio, Banfić, Hrvoje, Višnjić, Dora   +3 more
core   +1 more source

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi

mBio
Inositol phosphates are involved in a myriad of biological roles and activities such as Ca2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity.
Mayara S. Bertolini, Sabrina E. Cline, Miguel A. Chiurillo, Brian S. Mantilla, Aharon Eidex, Logan P. Crowe, Danye Qiu, Henning J. Jessen, Adolfo Saiardi, Roberto Docampo   +9 more
doaj   +1 more source