Results 51 to 60 of about 751 (180)

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi

mBio
Inositol phosphates are involved in a myriad of biological roles and activities such as Ca2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity.
Mayara S. Bertolini, Sabrina E. Cline, Miguel A. Chiurillo, Brian S. Mantilla, Aharon Eidex, Logan P. Crowe, Danye Qiu, Henning J. Jessen, Adolfo Saiardi, Roberto Docampo   +9 more
doaj   +1 more source

Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo

Nature Communications, 2016
Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far.
Igor Pavlovic, Divyeshsinh T. Thakor, Jessica R. Vargas, Colin J. McKinlay, Sebastian Hauke, Philipp Anstaett, Rafael C. Camuña, Laurent Bigler, Gilles Gasser, Carsten Schultz, Paul A. Wender, Henning J. Jessen   +11 more
doaj   +1 more source

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry [PDF]

, 2021
Inositol pyrophosphates (PP-InsPs) are an important group of intracellular signaling molecules. Derived from inositol phosphates (InsPs), these molecules feature the presence of at least one energetic pyrophosphate moiety on the myo-inositol ring.
Jessen, HJ, Saiardi, A, Qiu, D, Eisenbeis, VB   +3 more
core  

Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective [PDF]

Trends in Biochemical Sciences, 2017
Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated. Investigation into the role of inositol pyrophosphates (PP-IPs) has provided a novel perspective on the regulation of phosphate homeostasis.
Azevedo, C, Saiardi, A
openaire   +3 more sources

Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes.

PLoS Genetics, 2018
Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required for virulence in pathogenic fungi and provides an informative model of stress ...
Kaitlyn L Norman, Christian A Shively, Amberlene J De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J Cullen, Anuj Kumar   +6 more
doaj   +1 more source

Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis

Molecules, 2020
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including
Samuel E. Weinberg, Le Yu Sun, Allison L. Yang, Jie Liao, Guang Yu Yang   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders

Biomolecules
Inositol is a vital sugar molecule involved in numerous signaling pathways required for cellular homeostasis and cell survival. Myo-inositol and its phospho-derivatives, inositol phosphates (IPs), are the most prevalent forms of inositol found in living ...
Chisom J. Onu, Michael Adu, Mohamed Chakkour, Vikalp Kumar, Miriam L. Greenberg   +4 more
doaj   +1 more source

Role of transporters in regulating mammalian intracellular inorganic phosphate

Frontiers in Pharmacology, 2023
This review summarizes the current understanding of the role of plasma membrane transporters in regulating intracellular inorganic phosphate ([Pi]In) in mammals. Pi influx is mediated by SLC34 and SLC20 Na+-Pi cotransporters.
Michael L. Jennings
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source