Results 71 to 80 of about 903 (153)

Inositol Pyrophosphates as Versatile Metabolic Messengers

Annual Review of Biochemistry
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling metabolites whose versatile modes of action are being increasingly appreciated. These include their emerging roles as energy regulators, phosphodonors, steric/allosteric regulators, and G protein–coupled receptor messengers.
Latika, Nagpal, Sining, He, Feng, Rao, Solomon H, Snyder   +3 more
openaire   +2 more sources

The Key Role of IP₆K: A Novel Target for Anticancer Treatments?

Molecules, 2020
Inositol and its phosphate metabolites play a pivotal role in several biochemical pathways and gene expression regulation: inositol pyrophosphates (PP-IPs) have been increasingly appreciated as key signaling modulators.
Mirko Minini, Alice Senni, Vittorio Unfer, Mariano Bizzarri   +3 more
doaj   +1 more source

Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Chromaffin cells and platelets both utilize exocytosis to release biogenic amines stored within large dense‐core vesicles—specifically chromaffin granules (epinephrine) and δ‐granules (serotonin). While the chromaffin cell is the foundational model for studying the secretory pathway, platelets offer a highly accessible human cell source for clinical ...
Ricardo Borges
wiley   +1 more source

Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?

Molecules, 2020
The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Caitlin Cridland, Glenda Gillaspy
doaj   +1 more source

PHR1 mediates rapid high light responses and acclimation to high photosynthetic activity

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Changing light intensity requires immediate metabolic adjustment which involves reprogramming of both plastidial and nuclear gene expression, but the signaling pathways behind such responses are not fully understood. Here we report that an increase in light intensity causes fluctuations of Pi levels in the chloroplasts of Arabidopsis thaliana ...
Lukas Ackermann, Agnes Fekete, Laura Schröder, Thomas Nägele, Alina J. Hieber, Monika Müller, Martin J. Mueller, Maria Klecker   +7 more
wiley   +1 more source

Fungal Inositol Pyrophosphate IP₇ Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity

mBio, 2015
Inositol pyrophosphates (PP-IPs) comprising inositol, phosphate, and pyrophosphate (PP) are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never been addressed.
Sophie Lev, Cecilia Li, Desmarini Desmarini, Adolfo Saiardi, Nicole L. Fewings, Stephen D. Schibeci, Raghwa Sharma, Tania C. Sorrell, Julianne T. Djordjevic   +8 more
doaj   +1 more source

Do Short‐Term Legume–Maize Sequences Outperform Maize Monoculture Regarding Biomass Production and P Use Efficiency Under P‐Restricted Conditions?

Journal of Plant Nutrition and Soil Science, Volume 189, Issue 2, Page 276-286, April 2026.
In a short‐term pot experiment, three legume‐based crop rotations are being tested for their effects on the P cycle and P use efficiency compared to maize monoculture. Legume‐based crop rotations stimulate the P cycle by increasing acid phosphatase activity and carboxylate exudation.
Michelle Natalie Herrmann, Michelle Ginter, Franz Neundorf, Daniel Wanke, Torsten Müller, Günter Neumann, Klara Bradáčová   +6 more
wiley   +1 more source

Micronutrients in Future Diets: Considerations for Dietary Iron and the Food Matrix Effects on Bioavailability

Molecular Nutrition &Food Research, Volume 70, Issue 8, 27 April 2026.
Optimising food and ingredient formulations accounting for the food matrix and potential impacts on iron bioavailability can support nutritional adequacy and warrants consideration to ensure future foods are both healthy and sustainable. ABSTRACT Adequate nutrition is an essential contributor to improved health, longevity, and quality of life in the ...
Prachi Punetha, Tom F. O'Callaghan, Elaine K. McCarthy   +2 more
wiley   +1 more source

Towards pharmacological intervention in inositol pyrophosphate signalling [PDF]

Biochemical Society Transactions, 2016
To help define the molecular basis of cellular signalling cascades, and their biological functions, there is considerable value in utilizing a high-quality chemical ‘probe’ that has a well-defined interaction with a specific cellular protein. Such reagents include inhibitors of protein kinases and small molecule kinases, as well as mimics or ...
openaire   +2 more sources

Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes [PDF]

Advances in Enzyme Regulation, 2010
Inositol phosphates and inositol pyrophosphates are small molecule metabolites that play important roles in nuclear processes such as transcription control, mRNA export and DNA repair. On this wonderful occasion of the fiftieth anniversary of the Advances in Enzyme Regulation conference, it is a privilege to participate through presenting recent ...
Marco M, Tsui, John D, York
openaire   +2 more sources