Results 71 to 80 of about 38,827 (170)

Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus

The EMBO Journal
Kinases that synthesize inositol phosphates (IPs) and pyrophosphates (PP-IPs) control numerous biological processes in eukaryotic cells. Herein, we extend this cellular signaling repertoire to viruses. We have biochemically and structurally characterized
Guangning Zong, Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B. Shears, Huanchen Wang   +6 more
doaj   +1 more source

Role of transporters in regulating mammalian intracellular inorganic phosphate

Frontiers in Pharmacology, 2023
This review summarizes the current understanding of the role of plasma membrane transporters in regulating intracellular inorganic phosphate ([Pi]In) in mammals. Pi influx is mediated by SLC34 and SLC20 Na+-Pi cotransporters.
Michael L. Jennings
doaj   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event [PDF]

Proceedings of the National Academy of Sciences, 2007
In a previous study, we showed that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP 7 ) physiologically phosphorylates mammalian and yeast proteins. We now report that this phosphate transfer reflects pyrophosphorylation.
Bhandari, Rashna, Saiardi, Adolfo, Ahmadibeni, Yousef, Snowman, Adele M., Resnick, Adam C., Kristiansen, Troels Z., Molina, Henrik, Pandey, Akhilesh, Werner, J. Kent, Jr., Juluri, Krishna R., Xu, Yong, Prestwich, Glenn D., Parang, Keykavous, Snyder, Solomon H.   +13 more
openaire   +3 more sources

Global Proteomic Analysis of Sperm and Seminal Plasma From Tropically‐Adapted Rams With Contrasting Parameters of Frozen‐Thawed Semen

Molecular Reproduction and Development, Volume 93, Issue 10, October 2026.
ABSTRACT The aim of this study was to characterize the proteome of sperm and seminal plasma (SP) from rams with high semen freezability (HF) and low semen freezability (LF). Eleven ejaculates were collected from 12 rams, at 3‐day intervals, and cryopreserved (132 semen samples).
Wallisson Bruno de Morais Pacheco, Iran Aguila Maciel, Suane Santos Alves dos Santos, Alan Martins de Araújo, Francisca Nágila Matos Almeida, Denise Damasceno Guerreiro, Sheheryar Sheheryar, Lais Lacerda Brasil de Oliveira, Felipe Domingos de Sousa, Mohibullah Shah, Maria Elisabete Amaral Moraes, Carlos Roberto Koscky Paier, Ana Cristina de Oliveira Monteiro, Carminda Sandra Brito Salmito‐Vanderley, Arlindo A. Moura   +14 more
wiley   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3569-3592, October 2026.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Inositol Pyrophosphates as Versatile Metabolic Messengers

Annual Review of Biochemistry
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling metabolites whose versatile modes of action are being increasingly appreciated. These include their emerging roles as energy regulators, phosphodonors, steric/allosteric regulators, and G protein–coupled receptor messengers.
Latika, Nagpal, Sining, He, Feng, Rao, Solomon H, Snyder   +3 more
openaire   +2 more sources

SlMED25‐SlPHR3‐SlSPX2 module fine‐tunes SlPHR3‐mediated transcriptional activation of phosphate starvation response in tomato

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3593-3609, October 2026.
The mediator subunit SlMED25 and the co‐repressor SlSPX2 competitively bind the N‐terminal domain of the phosphate starvation response transcription factor SlPHR3 in tomato to form a sensitive molecular switch, which dynamically modulates phosphate starvation responses and maintains phosphate homeostasis, offering valuable targets for breeding low ...
Mingtong Zhai, Hongyu Han, Yu Zhang, Yunfeng Zhao, Hongying Guo, Hui Wang, Chuanlong Sun, Xianwen Meng, Lei Deng, Qian Chen, Chuanyou Li   +10 more
wiley   +1 more source

Inositol pyrophosphates modulate hydrogen peroxide signalling

Biochemical Journal, 2009
Inositol pyrophosphates are involved in a variety of cellular functions, but the specific pathways and/or downstream targets remain poorly characterized. In the present study we use Saccharomyces cerevisiae mutants to examine the potential roles of inositol pyrophosphates in responding to cell damage caused by ROS (reactive oxygen species).
Onnebo, Sara Maria Nancy, Saiardi, Adolfo   +1 more
openaire   +3 more sources

Mass spectrometry analysis of inositol pyrophosphates purified from D. Discoideum cell extract.

, 2014
Gel purified inositol pyrophosphates (A) were subjected to mass spectrometry (B,C). The comparison of the m/z spectrum of IP7 (B) and IP8 (C) is shown. The peaks in the spectra describing inositol pyrophosphates purified from D.
Thomas Livermore (507716), Marco Gaspari (77912), Adolfo Saiardi (263859), Francesca Pisani (507715), Giuseppina Rose (80339), Jonathan Robert Chubb (507717)   +5 more
core   +1 more source