Results 91 to 100 of about 38,827 (170)

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis [PDF]

, 2015
Diphosphorylated inositol polyphosphates, also referred to as inositol pyrophosphates, are important signaling molecules that regulate critical cellular activities in many eukaryotic organisms, such as membrane trafficking, telomere maintenance, ribosome
Zheng, Ning, Schaaf, Gabriel, Dynowski, Marek, Campos, Marília K. F. de, Weiß, Michael, van Wees, Saskia C. M., Sub Plant-Microbe Interactions, Iven, Tim, de Campos, Marília K F, Capolicchio, Samanta, Saiardi, Adolfo, Wees, Saskia C. M. van, Jessen, Henning J., Laha, Debabrata, Jessen, Henning J, Jessen, Henning, Plant Microbe Interactions, Mao, Haibin, Feussner, Ivo, Freyer, Marc, Azevedo, Cristina, Steenbergen, Merel, de Campos, Marilia K. F., Gaugler, Philipp, Johnen, Philipp, van Wees, Saskia C M, Laha D, de Campos MK, Weiß M, Mao H, Feussner I, Zheng N, Azevedo C, Gaugler P, Dynowski M, Johnen P, Van Wees SC, Iven T, Freyer M, Schaaf G, Jessen HJ, Capolicchio S, Saiardi A, Steenbergen M   +43 more
core   +1 more source

The Key Role of IP₆K: A Novel Target for Anticancer Treatments?

Molecules, 2020
Inositol and its phosphate metabolites play a pivotal role in several biochemical pathways and gene expression regulation: inositol pyrophosphates (PP-IPs) have been increasingly appreciated as key signaling modulators.
Mirko Minini, Alice Senni, Vittorio Unfer, Mariano Bizzarri   +3 more
doaj   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Fungal Inositol Pyrophosphate IP₇ Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity

mBio, 2015
Inositol pyrophosphates (PP-IPs) comprising inositol, phosphate, and pyrophosphate (PP) are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never been addressed.
Sophie Lev, Cecilia Li, Desmarini Desmarini, Adolfo Saiardi, Nicole L. Fewings, Stephen D. Schibeci, Raghwa Sharma, Tania C. Sorrell, Julianne T. Djordjevic   +8 more
doaj   +1 more source

Strigolactone‐mediated architecture regulation and stress resilience: Insights and innovations for crop breeding

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 2548-2576, August 2026.
This review summarizes the discovery, biosynthesis, and transport of strigolactone, and the D14‐D3/MAX2‐D53/SMXLs signaling module. It highlights diverse roles of strigolactone in plant architecture, stress responses, and crop breeding, including species‐specific functions, hormonal crosstalk, and agricultural applications.
Qingliang Hu, Jiayang Li, Bing Wang
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, Volume 13, Issue 37, 3 July 2026.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Towards pharmacological intervention in inositol pyrophosphate signalling [PDF]

Biochemical Society Transactions, 2016
To help define the molecular basis of cellular signalling cascades, and their biological functions, there is considerable value in utilizing a high-quality chemical ‘probe’ that has a well-defined interaction with a specific cellular protein. Such reagents include inhibitors of protein kinases and small molecule kinases, as well as mimics or ...
openaire   +2 more sources

Cellular adaptations of fission yeast to inositol starvation

mBio
Inositol is an essential nutrient and a precursor of phosphorylated metabolites that play important roles in cell physiology. Here we characterize the impact of intracellular inositol deficiency, taking advantage of fission yeast Schizosaccharomyces ...
Ana M. Sanchez, Jill Babor, Michelle Saoi, Isabel Prucker, Henning J. Jessen, Beate Schwer, Stewart Shuman   +6 more
doaj   +1 more source

Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione‐resistant Amaranthus tuberculatus biotype

Pest Management Science, Volume 82, Issue 7, Page 6387-6398, July 2026.
Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest, Marianne Bessette, Geneviève Gagnon, Sandra Flores‐Mejia, Brahim Soufiane, Marie‐Claire Goulet, Dominique Michaud   +6 more
wiley   +1 more source