Results 111 to 120 of about 38,827 (170)

A linear pathway for inositol pyrophosphate metabolism revealed by 18O labeling and model reduction.

PLoS Computational Biology
The homeostasis of intracellular inorganic phosphate is essential for eukaryotic metabolism and is regulated by the INPHORS signalling pathway, which employs inositol pyrophosphates (IPPs) as key intermediary messengers.
Jacques Hermes, Geun-Don Kim, Guizhen Liu, Maria Giovanna De Leo, Andreas Mayer, Henning Jessen, Jens Timmer   +6 more
doaj   +1 more source

VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP₈ and Jasmonate-Dependent Defenses in Arabidopsis [PDF]

, 2015
Diphosphorylated inositol polyphosphates, also referred to as inositol pyrophosphates, are important signaling molecules that regulate critical cellular activities in many eukaryotic organisms, such as membrane trafficking, telomere maintenance, ribosome
Johnen, P, De Campos, MKF, Zheng, N, Freyer, M, Feussner, I, Laha, D, Gaugler, P, Iven, T, Azevedo, C, Weiss, M, Steenbergen, M, Jessen, HJ, Saiardi, A, Mao, H, Capolicchio, S, Van Wees, SCM, Schaaf, G, Dynowski, M   +17 more
core   +1 more source

Science: Pathogenic fungi exploit plant phosphate sensing via Nudix hydrolase effectors

Advanced Agrochem
Inorganic phosphate (Pi) homeostasis in plants is regulated by inositol pyrophosphates (PP-InsPs), which mediate phosphate starvation responses. While beneficial microorganisms, such as arbuscular mycorrhizal fungi, contribute to phosphate uptake ...
Yi-Xuan Fu, Ying Ye
doaj   +1 more source

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis. [PDF]

Nat Commun, 2021
Ried MK, Wild R, Zhu J, Pipercevic J, Sturm K, Broger L, Harmel RK, Abriata LA, Hothorn LA, Fiedler D, Hiller S, Hothorn M.   +11 more
europepmc   +1 more source

Crystal structure and enzymology of solanum tuberosum inositol tris/tetrakisphosphate kinase 1 (StITPK1) [PDF]

Inositol phosphates and their pyrophosphorylated derivatives are responsive to the phosphate supply and are agents of phosphate homeostasis and other aspects of physiology. It seems likely that the enzymes that interconvert these signals work against the
Shipton, Megan L., Potter, Barry V. L., Hemmings, Andrew M., Faba Rodriguez, Raquel, Whitfield, Hayley L., Brearley, Charles A., Riley, Andrew M., Li, Arthur W. H.   +7 more
core   +1 more source

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

Nature Communications
Inositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenger 1,5-InsP8, the C-terminal phosphatase domain catalyzes PP-InsP breakdown ...
Pierre Raia, Kitaik Lee, Simon M. Bartsch, Felix Rico-Resendiz, Daniela Portugal-Calisto, Oscar Vadas, Vikram Govind Panse, Dorothea Fiedler, Michael Hothorn   +8 more
doaj   +1 more source

Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development.

PLoS Genetics
Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Florian Laurent, Simon M Bartsch, Anuj Shukla, Felix Rico-Resendiz, Daniel Couto, Christelle Fuchs, Joël Nicolet, Sylvain Loubéry, Henning J Jessen, Dorothea Fiedler, Michael Hothorn   +10 more
doaj   +1 more source

Inositol pyrophosphates in cell death and life [PDF]

Cell Cycle, 2011
Michael A, Koldobskiy, Solomon H, Snyder
openaire   +2 more sources

Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2. [PDF]

Mol Cell, 2020
Rao F, Cha J, Xu J, Xu R, Vandiver MS, Tyagi R, Tokhunts R, Koldobskiy MA, Fu C, Barrow R, Wu M, Fiedler D, Barrow JC, Snyder SH.   +13 more
europepmc   +1 more source

Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination. [PDF]

Nucleic Acids Res, 2019
Sanchez AM, Garg A, Shuman S, Schwer B.
europepmc   +1 more source