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Unveiling the Plasmodium inositol (pyro)phosphate pathway: Highlighting inositol polyphosphate multikinase as a novel therapeutic target for malaria. [PDF]
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Inositol pyrophosphates: metabolism and signaling
Cellular and Molecular Life Sciences, 2006Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that have a range of signaling functions. Since the discovery of inositol pyrophosphates in the early 1990s, enormous progress has been achieved in characterising this class of molecules, linking their biological presence to a wide range of cellular functions ...
Cristina Azevedo, Adolfo Saiardi
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Inositol pyrophosphates regulate endocytic trafficking [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2002 The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established.
Adolfo Saiardi, Solomon H Snyder
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Phosphorylation of Proteins by Inositol Pyrophosphates
Science, 2004The inositol pyrophosphates IP 7 and IP 8 contain highly energetic pyrophosphate bonds. Although implicated in various biologic functions, their molecular sites of action have not been clarified. Using radiolabeled IP 7
Adolfo, Saiardi +4 more
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Understanding Inositol Pyrophosphates
Science's STKE, 2007Inositol pyrophosphates are relatively poorly understood, highly phosphorylated members of the inositol polyphosphate family. Two studies describe related advances in signaling involving inositol pyrophosphates. Mulugu et al . purified an inositol pyrophosphate synthase from yeast, called Vip1. Lee et al
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Inositol pyrophosphates: between signalling and metabolism
Biochemical Journal, 2013The present review will explore the insights gained into inositol pyrophosphates in the 20 years since their discovery in 1993. These molecules are defined by the presence of the characteristic ‘high energy’ pyrophosphate moiety and can be found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be
Miranda S C, Wilson +2 more
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Photo-releasable derivatives of inositol pyrophosphates
2020The specific non-invasive control of intracellular signaling events requires advanced tools that enter cells by diffusion and are controllable by light. Here, we detail the synthesis and application of membrane-permeant caged inositol pyrophosphates with respect to cell entry and cell distribution.
Hauke, Sebastian +3 more
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