Results 101 to 110 of about 38,827 (170)

Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport

, 2016
Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are conserved eukaryotic signaling molecules that possess pyrophosphate and monophosphate moieties. Generated predominantly by Inositol Hexakisphosphate Kinases (IP6Ks), inositol
Chanduri, Manasa, Wu, Mingxuan, Malla, Aushaq Bashir, Fiedler, Dorothea, Rai, Ashim, Mallik, Roop, Bhandari, Rashna   +6 more
core   +1 more source

Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers

, 2022
Inositol pyrophosphates are signaling molecules containing at least one phosphoanhydride bond that regulate a wide range of cellular processes in eukaryotes.
Liu, Guizhen, Schaaf, Gabriel, Laha, Debabrata, Ritter, Kevin, Jessen, Henning, Häner, Markus, Weber, Jonathan, Fernandez-Rebollo, Nicolas, Yadav, Ranjana, Schmid, Jochen, Trung, Minh Nguyen, Schneider, Robin, Gaugler, Philipp, Gaugler, Verena, Fiedler, Dorothea, Qiu, Danye, Giehl, Ricardo F. H., Jork, Nikolaus   +17 more
core   +1 more source

Inositol biosynthesis is fine‐tuned by inositol pyrophosphates in Saccharomyces cerevisiae

The FASEB Journal, 2013
In yeast , inositol biosynthesis is coordinated with the synthesis of phospholipids by controlling the expression of enzymes in the biosynthetic pathways. Inositol pyrophosphates, most recently characterized in the inositide family, have diverse roles in phosphate signaling and other ...
Cunqi Ye, Miriam L Greenberg
openaire   +1 more source

Crystal Structure and Enzymology of Solanum tuberosum Inositol Tris/Tetrakisphosphate Kinase 1 (StITPK1)

, 2023
Inositol phosphates and their pyrophosphorylated derivatives are responsive to the phosphate supply and are agents of phosphate homeostasis and other aspects of physiology. It seems likely that the enzymes that interconvert these signals work against the
Barry V.L. Potter (14871426), Raquel Faba Rodriguez (17701802), Arthur W.H. Li (17701808), Megan L. Shipton (17701805), Hayley L. Whitfield (17701799), Andrew M. Riley (286874), Charles A. Brearley (5770325), Andrew M. Hemmings (2345116)   +7 more
core   +1 more source

Inositol Pyrophosphates and Phosphate Sensing in Plants

The FASEB Journal, 2019
Phosphate (P i ) is an essential nutrient for plants, required for plant growth and seed viability. Under P i stress, plants undergo dynamic changes to leverage available P i .
Glenda Gillaspy, Olusegun Adepoju, Eric Land, Sarah Phoebe Williams, Janet Donahue, Caitlin Cridland, Catherine Freed, Imara Perera   +7 more
openaire   +1 more source

Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability

Molecular Brain
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin, Aili Liu, Alfred C. Chin, Chenglai Fu, Hui Shen, Weiwei Cheng   +5 more
doaj   +1 more source

The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes [PDF]

, 2017
Inositol pyrophosphates are novel signaling molecules possessing high-energy pyrophosphate bonds and involved in a number of biological functions. Here, we report the correct identification and characterization of the kinases involved in the inositol ...
Cordeiro, CD, Saiardi, A, Docampo, R
core   +1 more source

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues. [PDF]

Chem Sci, 2023
Qiu D, Gu C, Liu G, Ritter K, Eisenbeis VB, Bittner T, Gruzdev A, Seidel L, Bengsch B, Shears SB, Jessen HJ.   +10 more
europepmc   +1 more source

Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in Saccharomyces cerevisiae

Biomolecules
The inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Ileana Cornelia Farcasanu   +2 more
doaj   +1 more source

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs. [PDF]

Chem Sci, 2021
Hostachy S, Utesch T, Franke K, Dornan GL, Furkert D, Türkaydin B, Haucke V, Sun H, Fiedler D.   +8 more
europepmc   +1 more source