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Influence of Inositol Pyrophosphates on Cellular Energy Dynamics
Science, 2011Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
Zsolt Szijgyarto +2 more
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A Discrete Signaling Function for an Inositol Pyrophosphate
Science's STKE, 2007Inositol pyrophosphates were, until recently, without clearly defined functions. Two recent papers in Science have now clearly defined a function for an IP 7 pyrophosphate (inositol hexaphosphate with one pyrophosphate) that is the product of the enzyme encoded by the Vip1
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Cell Signalling by Inositol Pyrophosphates
2012Inositol serves as a module for the generation of a high level of molecular diversity through the combinatorial attachment and removal of phosphate groups. The array of potential inositol-containing molecules is further expanded by the generation of diphospho inositol polyphosphates, commonly referred as inositol pyrophosphates.
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Enzymatic Synthesis of Inositol Pyrophosphates
The availability of well-defined and pure PP-InsP substrates in high quantities is pivotal to study their molecular mechanisms by means of biochemical or biophysical approaches. Here, we present a workflow employing enzymatic synthesis that allows for the quick and easy synthesis and isolation of mammalian PP-InsP isomers.Simon M, Bartsch, Dorothea, Fiedler
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Inositol pyrophosphate kinases in health and disease
FEBS LettersInositol phosphates (InsPs) are intracellular signaling molecules that are essential for life. Inositol pyrophosphates, a subset of inositol phosphates, are the end products of inositol phosphate metabolism. In mammalian cells, up to 90% of inositol pyrophosphates are 5‐diphosphoinositol 1,2,3,4,6‐pentakisphosphate (5PP‐InsP
Changchang Xing +6 more
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Inositol Pyrophosphates in Metabolism Control
Science Signaling, 2011Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
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Visualizing and Identifying Inositol Pyrophosphate Isomers in Crystallo
Inositol pyrophosphates (PP-InsPs), which possess functionally significant diphosphate groups, regulate a wide range of biological processes across eukaryotic organisms. The presence and isomeric diversity of PP-InsPs suggest potential biological relevance and enable these molecules to serve as versatile regulators.Guangning, Zong, Huanchen, Wang
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Enabling Technologies for the Dissection of Inositol Pyrophosphate Physiology
The diverse chemical structures of inositol pyrophosphates attract growing interest toward this class of small molecule messengers. However, their highly charged nature, the lack of a chromophore or a fluorophore, their close structural relatedness, and the complexity of their metabolism pose serious challenges to inositol pyrophosphates studies. Here,Adolfo, Saiardi +2 more
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The inositol pyrophosphates are essential for the development of mammals [PDF]
, 2022 Inositol polyphosphates, generated from a second messenger IP3 by a series of kinases, are a family of endogenous metabolites conserved across evolution. Inositol polyphosphates participate in diverse physiological activities, including insulin secretion, ubiquitination, apoptosis, cancer development.
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