Results 151 to 160 of about 751 (180)

Inositol pyrophosphates: metabolism and signaling

Cellular and Molecular Life Sciences, 2006
Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that have a range of signaling functions. Since the discovery of inositol pyrophosphates in the early 1990s, enormous progress has been achieved in characterising this class of molecules, linking their biological presence to a wide range of cellular functions ...
Malcolm J Bennett, CARLOS Azevedo, Adolfo Saiardi   +2 more
exaly   +3 more sources

Inositol Pyrophosphates in Metabolism Control

Science Signaling, 2011
Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
L. Bryan Ray
core   +3 more sources

Inositol pyrophosphates: structure, enzymology and function

Cellular and Molecular Life Sciences, 2009
The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the ...
Christopher John, Barker, Christopher, Illies, Gian Carlo, Gaboardi, Per-Olof, Berggren   +3 more
openaire   +3 more sources

Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length [PDF]

Advances in Biological Regulation, 2016
Synthesis of inositol pyrophosphates through activation of Kcs1 plays an important role in the signalling response required for cell cycle progression after mating pheromone arrest. Overexpression of Kcs1 doubled the level of inositol pyrophosphates when
Hrvoje Banfić, Vladiana Crljen, Vilma Dembitz   +2 more
exaly   +2 more sources

Enabling Technologies for the Dissection of Inositol Pyrophosphate Physiology

The diverse chemical structures of inositol pyrophosphates attract growing interest toward this class of small molecule messengers. However, their highly charged nature, the lack of a chromophore or a fluorophore, their close structural relatedness, and the complexity of their metabolism pose serious challenges to inositol pyrophosphates studies. Here,
Adolfo, Saiardi, Henning J, Jessen, Dorothea, Fiedler   +2 more
openaire   +3 more sources

The emerging roles of inositol pyrophosphates in eukaryotic cell physiology

Journal of Biosciences, 2015
Inositol pyrophosphates are water soluble derivatives of inositol that contain pyrophosphate or diphosphate moieties in addition to monophosphates. The best characterised inositol pyrophosphates, are IP7 (diphosphoinositol pentakisphosphate or PP-IP5 ...
Rashna Bhandari, Bhandari Rashna
exaly   +2 more sources

The inositol pyrophosphates are essential for the development of mammals [PDF]

, 2022
Inositol polyphosphates, generated from a second messenger IP3 by a series of kinases, are a family of endogenous metabolites conserved across evolution. Inositol polyphosphates participate in diverse physiological activities, including insulin secretion, ubiquitination, apoptosis, cancer development.
He, Sining
openaire   +2 more sources

Understanding the Catabolism of Inositol Pyrophosphates in Plants

Inositol pyrophosphates (PP-InsPs) are vital nutrient messengers that finely regulate plant phosphate homeostasis, vital for growth and development. The enzyme VIP1, member of the PPIP5K kinase family, central to this network, generates the key signaling molecule 1,5-InsP8 and also participates in its breakdown. Alongside VIP1, Plant and Fungi Atypical
Laurent, Florian
openaire   +2 more sources

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast [PDF]

Cell, 2023
Although many prokaryotes have glycolysis alternatives, it\u27s considered as the only energy-generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid-glycolysis yeast.
Shi, Shuobo,, Nielsen, Jens B, Ji, Xu,, Zhang, Yiming, Liu, Zihe, Chen, Yun,, Yin, Shile, Ji, Xu, Nielsen, Jens, Qiu, Danye,, Zhang, Yue-Ping, Qin, Ning, Qin, Ning,, Wan, Xiaozhen,, Luo, Hao,, Li, Lingyun,, Xia, Jianye, Yin, Shile,, Larsson, Christer, Zhang, Yiming,, Jiang, Junfeng,, Jessen, Henning J., Luo, Hao, Larsson, Christer,, Pereira, Rui,, Chen, Yu,, Tan, Tianwei, Zhang, Yueping, Jessen, Henning, Dong, Genlai, Chen, Yu, Zhang, Yueping,, Li, Chaokun,, Xia, Jianye,, Liu, Zihe,, Li, Chaokun, Dong, Genlai,, Pereira, Rui, Wan, Xiaozhen, Tan, Tianwei,, Li, Lingyun, Jiang, Junfeng, Chen, Yun, Jessen, Henning J.,, Nielsen, Jens B,, Qiu, Danye, Shi, Shuobo   +46 more
exaly   +2 more sources

Phosphorylation of Proteins by Inositol Pyrophosphates

Science, 2004
The inositol pyrophosphates IP 7 and IP 8 contain highly energetic pyrophosphate bonds. Although implicated in various biologic functions, their molecular sites of action have not been clarified. Using radiolabeled IP 7
Adolfo, Saiardi, Rashna, Bhandari, Adam C, Resnick, Adele M, Snowman, Solomon H, Snyder   +4 more
openaire   +2 more sources