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Cell, 2003 Inositol phosphates are well-known signaling molecules, whereas the inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP7/IP7) and bis-diphosphoinositol tetrakisphosphate (InsP8/IP8), are less well characterized.
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Understanding Inositol Pyrophosphates
Science's STKE, 2007Inositol pyrophosphates are relatively poorly understood, highly phosphorylated members of the inositol polyphosphate family. Two studies describe related advances in signaling involving inositol pyrophosphates. Mulugu et al . purified an inositol pyrophosphate synthase from yeast, called Vip1. Lee et al
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Inositol pyrophosphates: between signalling and metabolism
Biochemical Journal, 2013The present review will explore the insights gained into inositol pyrophosphates in the 20 years since their discovery in 1993. These molecules are defined by the presence of the characteristic ‘high energy’ pyrophosphate moiety and can be found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be
Miranda S C, Wilson +2 more
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Photo-releasable derivatives of inositol pyrophosphates
2020The specific non-invasive control of intracellular signaling events requires advanced tools that enter cells by diffusion and are controllable by light. Here, we detail the synthesis and application of membrane-permeant caged inositol pyrophosphates with respect to cell entry and cell distribution.
Hauke, Sebastian +3 more
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A Discrete Signaling Function for an Inositol Pyrophosphate
Science's STKE, 2007Inositol pyrophosphates were, until recently, without clearly defined functions. Two recent papers in Science have now clearly defined a function for an IP 7 pyrophosphate (inositol hexaphosphate with one pyrophosphate) that is the product of the enzyme encoded by the Vip1
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Cell Signalling by Inositol Pyrophosphates
2012Inositol serves as a module for the generation of a high level of molecular diversity through the combinatorial attachment and removal of phosphate groups. The array of potential inositol-containing molecules is further expanded by the generation of diphospho inositol polyphosphates, commonly referred as inositol pyrophosphates.
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Enzymatic Synthesis of Inositol Pyrophosphates
The availability of well-defined and pure PP-InsP substrates in high quantities is pivotal to study their molecular mechanisms by means of biochemical or biophysical approaches. Here, we present a workflow employing enzymatic synthesis that allows for the quick and easy synthesis and isolation of mammalian PP-InsP isomers.Simon M, Bartsch, Dorothea, Fiedler
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Inositol pyrophosphate kinases in health and disease
FEBS LettersInositol phosphates (InsPs) are intracellular signaling molecules that are essential for life. Inositol pyrophosphates, a subset of inositol phosphates, are the end products of inositol phosphate metabolism. In mammalian cells, up to 90% of inositol pyrophosphates are 5‐diphosphoinositol 1,2,3,4,6‐pentakisphosphate (5PP‐InsP
Changchang Xing +6 more
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Visualizing and Identifying Inositol Pyrophosphate Isomers in Crystallo
Inositol pyrophosphates (PP-InsPs), which possess functionally significant diphosphate groups, regulate a wide range of biological processes across eukaryotic organisms. The presence and isomeric diversity of PP-InsPs suggest potential biological relevance and enable these molecules to serve as versatile regulators.Guangning, Zong, Huanchen, Wang
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