Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis [PDF]
The Journal of Clinical Investigation, 2023 How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney phosphate reabsorption and 1,25(OH)2D production, but phosphate does not directly ...
Wen Zhou +14 more
doaj +3 more sources
The Complexities of Organ Crosstalk in Phosphate Homeostasis: Time to Put Phosphate Sensing Back in the Limelight [PDF]
International Journal of Molecular Sciences, 2021 Phosphate homeostasis is essential for health and is achieved via interaction between the bone, kidney, small intestine, and parathyroid glands and via intricate processes involving phosphate transporters, phosphate sensors, and circulating hormones ...
Sarah Beck-Cormier +2 more
exaly +4 more sources
Age-dependent sex differences in calcium and phosphate homeostasis [PDF]
Endocrine Connections, 2021 Background: Sex differences in calcium and phosphate have been observed. We aimed to assess a relation with age. Methods: We used the laboratory values of serum calcium, phosphate and albumin from three different samples ( 2005, 2010 and 2014 years ...
W N H Koek +7 more
doaj +3 more sources
Maintenance of cellular vitamin B6 levels and mitochondrial oxidative function depend on pyridoxal 5'-phosphate homeostasis protein. [PDF]
J Biol Chem, 2023 Recently, biallelic variants in PLPBP coding for pyridoxal 5′-phosphate homeostasis protein (PLPHP) were identified as a novel cause of early-onset vitamin B6–dependent epilepsy.
Ciapaite J +11 more
europepmc +2 more sources
Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis. [PDF]
Nat Commun, 2023 Osteoclasts are derived from circulating myeloid cells to mediate bone repair, maintenance and remodeling. Here, the authors show that the lung also recruits and reprograms monocytes and alveolar macrophages into osteoclast-like cells to clear pathogenic
Uehara Y +23 more
europepmc +2 more sources
BMC Biology, 2021 Background Leaf senescence is a genetically controlled degenerative process intimately linked to phosphate homeostasis during plant development and responses to environmental conditions.
Chao Ma +3 more
doaj +2 more sources
Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 - PHR2 complex. [PDF]
Nat Commun, 2022 Phosphate (Pi) starvation response (PHR) transcription factors play key roles in plant Pi homeostasis maintenance. They are negatively regulated by stand-alone SPX proteins, cellular receptors for inositol pyrophosphate (PP-InsP) nutrient messengers. How
Guan Z +16 more
europepmc +2 more sources
Medicago SPX1 and SPX3 regulate phosphate homeostasis, mycorrhizal colonization, and arbuscule degradation. [PDF]
Plant Cell, 2021 To acquire sufficient mineral nutrients such as phosphate (Pi) from the soil, most plants engage in a symbiosis with arbuscular mycorrhizal (AM) fungi.
Wang P +5 more
europepmc +2 more sources
ZmPHR1 contributes to drought resistance by modulating phosphate homeostasis in maize. [PDF]
Plant Biotechnol JAs an essential macronutrient, phosphorus (P) is often a limiting nutrient because of its low availability and mobility in soils. Drought is a major environmental stress that reduces crop yield. How plants balance and combine P‐starvation responses (PSRs)
Tian MZ +9 more
europepmc +2 more sources
Effects of empagliflozin on markers of calcium and phosphate homeostasis in patients with type 2 diabetes - Data from a randomized, placebo-controlled study. [PDF]
Bone Rep, 2022 Background and aim Sodium-glucose cotransporter-2 (SGLT2) inhibitors, glucose-lowering drugs that increase urinary glucose excretion have been shown to reduce CV events in patients with type 2 diabetes (T2D).
Rau M +7 more
europepmc +2 more sources