Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. [PDF]
PLoS Genetics, 2008 Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization.
Despina Sitara +7 more
doaj +3 more sources
Multifaceted role of autophagy in regulating phosphate homeostasis and developmental root plasticity. [PDF]
Autophagy Rep, 2023 Macroautophagy/autophagy delivers cytoplasmic constituents to the lysosome/vacuole for degradation and recycling, wherein regulates diverse aspects of cellular homeostasis.
Liu TY, Lung HF, Chiu CY, Chow HX.
europepmc +2 more sources
(Pro)renin Receptor Regulates Phosphate Homeostasis in Rats via Releasing Fibroblast Growth Factor-23. [PDF]
Front Physiol, 2022 Phosphate (Pi) is one of the basic necessities required for sustenance of life and its metabolism largely relies on excretory function of the kidney, a process chiefly under the endocrine control of bone-derived fibroblast growth factor 23 (FGF23 ...
Lu A +7 more
europepmc +2 more sources
Downregulation of GeBP-like α factor by MiR827 suggests their involvement in senescence and phosphate homeostasis. [PDF]
BMC Biol, 2021 Background Leaf senescence is a genetically controlled degenerative process intimately linked to phosphate homeostasis during plant development and responses to environmental conditions.
Ma C, Chen Q, Wang S, Lers A.
europepmc +2 more sources
Age-dependent sex differences in calcium and phosphate homeostasis. [PDF]
Endocr Connect, 2021 Background: Sex differences in calcium and phosphate have been observed. We aimed to assess a relation with age. Methods: We used the laboratory values of serum calcium, phosphate and albumin from three different samples ( 2005, 2010 and 2014 years ...
Koek WNH +7 more
europepmc +2 more sources
Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. [PDF]
J Clin Invest, 2023 How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney phosphate reabsorption and 1,25(OH)2D production, but phosphate does not directly ...
Zhou W +14 more
europepmc +2 more sources
Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. [PDF]
, 2016 There is increasing interest in the potential for metabolic profiling to evaluate the progression of pulmonary hypertension (PH). However, a detailed analysis of the metabolic changes in lungs at the early stage of PH, characterized by increased ...
Black, Stephen M +10 more
core +16 more sources
A Role for Inositol Pyrophosphates in the Metabolic Adaptations to Low Phosphate in Arabidopsis
Metabolites, 2021 Phosphate is a major plant macronutrient and low phosphate availability severely limits global crop productivity. In Arabidopsis, a key regulator of the transcriptional response to low phosphate, phosphate starvation response 1 (PHR1), is modulated by a ...
Eric S. Land +7 more
doaj +1 more source
mBio, 2023 Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportunities.
Bethany Grace Bowring +10 more
doaj +1 more source
Phosphate homeostasis and disorders [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2014 Recent studies of inherited disorders of phosphate metabolism have shed new light on the understanding of phosphate metabolism. Phosphate has important functions in the body and several mechanisms have evolved to regulate phosphate balance including vitamin D, parathyroid hormone and phosphatonins such as fibroblast growth factor-23 (FGF23). Disorders
P, Manghat, R, Sodi, R, Swaminathan
openaire +2 more sources