Results 21 to 30 of about 2,579,257 (273)
Molecular Plant, 2019 SPX-domain-containing proteins (SPXs) play an important role in inorganic phosphate (Pi) sensing, signaling, and transport in eukaryotes. In plants, SPXs are known to integrate cellular Pi status and negatively regulate the activity of Pi central ...
Keke Yi, Ruan Wenyuan, Lei Xu
exaly +2 more sources
LPCAT1 controls phosphate homeostasis in a zinc-dependent manner
eLife, 2018 All living organisms require a variety of essential elements for their basic biological functions. While the homeostasis of nutrients is highly intertwined, the molecular and genetic mechanisms of these dependencies remain poorly understood.
Mushtak Kisko +10 more
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A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis
eLife, 2019 Cells must appropriately sense and integrate multiple metabolic resources to commit to proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic homeostasis through tRNA U34-thiolation. Despite amino acid sufficiency,
Ritu Gupta +5 more
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Phosphate homeostasis disorders.
Best practice & research. Clinical endocrinology & metabolism, 2018 Our understanding of the regulation of phosphate balance has benefited tremendously from the molecular identification and characterization of genetic defects leading to a number of rare inherited or acquired disorders affecting phosphate homeostasis. The
Marta Christov, H. Jüppner
semanticscholar +2 more sources
(Pro)renin Receptor Regulates Phosphate Homeostasis in Rats via Releasing Fibroblast Growth Factor-23 [PDF]
Frontiers in Physiology, 2022 Phosphate (Pi) is one of the basic necessities required for sustenance of life and its metabolism largely relies on excretory function of the kidney, a process chiefly under the endocrine control of bone-derived fibroblast growth factor 23 (FGF23 ...
Aihua Lu +7 more
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Plant Journal, 2018 Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to ...
Tzyy-Jen Chiou +2 more
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Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-ꞵ signaling [PDF]
iScienceSummary: One of the main regulators of phosphate homeostasis is fibroblast growth factor 23 (FGF23), secreted by osteocytes. The effects of organic versus inorganic dietary phosphate on this homeostasis are unclear.
Danielle M.A. Ratsma +5 more
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Effects of Dapagliflozin on Circulating Markers of Phosphate Homeostasis. [PDF]
American Society of Nephrology. Clinical Journal, 2018 BACKGROUND AND OBJECTIVES The sodium glucose cotransporter 2 (SGLT-2) inhibitor dapagliflozin is a novel drug for the treatment of diabetes mellitus.
Maarten A. de Jong +7 more
semanticscholar +2 more sources
Phosphate Homeostasis, Inflammation and the Regulation of FGF-23
Kidney & Blood Pressure Research, 2018 Fibroblast growth factor 23 (FGF23) is released primarily from osteoblasts/osteocytes in bone. In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1α 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1 ...
Florian Lang +5 more
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A Role for Inositol Pyrophosphates in the Metabolic Adaptations to Low Phosphate in Arabidopsis
Metabolites, 2021 Phosphate is a major plant macronutrient and low phosphate availability severely limits global crop productivity. In Arabidopsis, a key regulator of the transcriptional response to low phosphate, phosphate starvation response 1 (PHR1), is modulated by a ...
Eric S. Land +7 more
doaj +1 more source