Results 41 to 50 of about 642,082 (258)

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

eLife, 2019
Cells must appropriately sense and integrate multiple metabolic resources to commit to proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic homeostasis through tRNA U34-thiolation. Despite amino acid sufficiency,
Ritu Gupta, Adhish S Walvekar, Shun Liang, Zeenat Rashida, Premal Shah, Sunil Laxman   +5 more
doaj   +1 more source

The human pathogenic 91del7 mutation in SLC34A1 has no effect in mineral homeostasis in mice

Scientific Reports, 2022
Kidneys are key regulators of phosphate homeostasis. Biallelic mutations of the renal Na+/phosphate cotransporter SLC34A1/NaPi-IIa cause idiopathic infantile hypercalcemia, whereas monoallelic mutations were frequently noted in adults with kidney stones.
Cornelia Bieri, Arezoo Daryadel, Carla Bettoni, Eva-Maria Pastor-Arroyo, Udo Schnitzbauer, Nati Hernando, Carsten A. Wagner   +6 more
doaj   +1 more source

Protein synthesis controls phosphate homeostasis [PDF]

Genes & Development, 2018
Phosphorus is an essential element assimilated largely as orthophosphate (Pi). Cells respond to Pi starvation by importing Pi from their surroundings. We now report that impaired protein synthesis alone triggers a Pi starvation response even when Pi is plentiful in the extracellular milieu.
Pontes, Mauricio H., Groisman, Eduardo A.   +1 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans

Frontiers in Fungal Biology
There is an urgent need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin drugs that are fungicidal against other important fungal pathogens are ineffective against Cryptococcus neoformans, the causative agent of
Xianya Qu, Xianya Qu, Kabir Bhalla, Kabir Bhalla, Linda C. Horianopoulos, Linda C. Horianopoulos, Guanggan Hu, Armando Alcázar Magaña, Leonard J. Foster, Leonard J. Foster, Leonard J. Foster, Leandro Buffoni Roque da Silva, Matthias Kretschmer, James W. Kronstad, James W. Kronstad   +14 more
doaj   +1 more source

A vacuolar phosphate transporter essential for phosphate homeostasis in Arabidopsis [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Phosphate is an essential nutrient for plant growth, and inorganic phosphate (Pi) is stored largely in the vacuole of plant cells. Thus, vacuolar Pi maintains homeostasis of cytosolic Pi to ensure an optimal Pi supply for plants under variable Pi status in the soil. This study uncovered in
Liu, Jinlong, Yang, Lei, Luan, Mingda, Wang, Yuan, Zhang, Chi, Zhang, Bin, Shi, Jisen, Zhao, Fu-Geng, Lan, Wenzhi, Luan, Sheng   +9 more
openaire   +4 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Ca2+ efflux facilitated by co-transport of inorganic phosphate anion in the H+/Ca2+ antiporter YfkE

Communications Biology, 2023
Ca2+ is an important signaling messenger. In microorganisms, fungi, and plants, H+/Ca2+ antiporters (CAX) are known to play key roles in the homeostasis of intracellular Ca2+ by catalyzing its efflux across the cell membrane.
Wei Niu, Wenchang Zhou, Shuo Lu, Trung Vu, Vasanthi Jayaraman, José D. Faraldo-Gómez, Lei Zheng   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The Multifunctional Exchangers SLC26A7 and SLC26A9 Are Also Sodium-Dependent Transporters of Inorganic Phosphate

Physiologia
Background: The regulation of inorganic phosphate (Pi) homeostasis is predominantly mediated by the Pi transporters belonging to the SLC34 and SLC20 families of solute carriers. However, not all Pi handling can be explained by these transporters. In this
Gema Chopo-Escuin, Jorge A. Quílez, Cecilia Sosa, Natalia Guillén, Víctor Sorribas   +4 more
doaj   +1 more source