Results 61 to 70 of about 2,579,257 (273)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer

Nature Communications
Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat oxidative stress and support reductive biosynthesis. One major NADPH production route is the oxidative pentose phosphate pathway (committed step: glucose-6-phosphate ...
Tai-Jin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wen-Ping Wang, Samuel Wang, Vrushank Bhatt, E. Lopes, Zhi-Xian Hu, Michael Sun, Xuefei Luo, J. Ghergurovich, Xiaoyang Su, Joshua D. Rabinowitz, Eileen P. White, J. Y. Guo   +15 more
semanticscholar   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans

Frontiers in Fungal Biology
There is an urgent need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin drugs that are fungicidal against other important fungal pathogens are ineffective against Cryptococcus neoformans, the causative agent of
Xianya Qu, Xianya Qu, Kabir Bhalla, Kabir Bhalla, Linda C. Horianopoulos, Linda C. Horianopoulos, Guanggan Hu, Armando Alcázar Magaña, Leonard J. Foster, Leonard J. Foster, Leonard J. Foster, Leandro Buffoni Roque da Silva, Matthias Kretschmer, James W. Kronstad, James W. Kronstad   +14 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The human pathogenic 91del7 mutation in SLC34A1 has no effect in mineral homeostasis in mice

Scientific Reports, 2022
Kidneys are key regulators of phosphate homeostasis. Biallelic mutations of the renal Na+/phosphate cotransporter SLC34A1/NaPi-IIa cause idiopathic infantile hypercalcemia, whereas monoallelic mutations were frequently noted in adults with kidney stones.
Cornelia Bieri, Arezoo Daryadel, Carla Bettoni, Eva-Maria Pastor-Arroyo, Udo Schnitzbauer, Nati Hernando, Carsten A. Wagner   +6 more
doaj   +1 more source

Sphingosine 1-Phosphate Regulates Obesity and Glucose Homeostasis

International Journal of Molecular Sciences
One of the major global health and welfare issues is the treatment of obesity and associated metabolic disorders, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease.
Kazuo Kajita, Isao Ishii, Ichiro Mori, Motochika Asano, M. Fuwa, Hiroyuki Morita   +5 more
semanticscholar   +1 more source

Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3′ processing and transcription termination

bioRxiv, 2019
Fission yeast phosphate acquisition genes pho1, pho84, and tgp1 are repressed in phosphate-rich medium by transcription of upstream lncRNAs. Here we show that phosphate homeostasis is subject to metabolite control by inositol pyrophosphates (IPPs ...
Ana M. Sanchez, A. Garg, S. Shuman, Beate Schwer   +3 more
semanticscholar   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Multifunctional Exchangers SLC26A7 and SLC26A9 Are Also Sodium-Dependent Transporters of Inorganic Phosphate

Physiologia
Background: The regulation of inorganic phosphate (Pi) homeostasis is predominantly mediated by the Pi transporters belonging to the SLC34 and SLC20 families of solute carriers. However, not all Pi handling can be explained by these transporters. In this
Gema Chopo-Escuin, Jorge A. Quílez, Cecilia Sosa, Natalia Guillén, Víctor Sorribas   +4 more
doaj   +1 more source