Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host: A paradox explained by alkaline pH-simulated nutrient deprivation and expanded PHO pathway function. [PDF]
PLoS Pathogens, 2018 Sophie Lev, Julianne Teresa Djordjevic
doaj +3 more sources
mBio, 2023 Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportunities.
Bethany Grace Bowring +10 more
doaj +3 more sources
Multilayered Regulation of Fungal Phosphate Metabolism: From Molecular Mechanisms to Ecological Roles in the Global Phosphorus Cycle [PDF]
LifePhosphates are essential nutrients for living organisms, and they are involved in various biological processes, including lipid metabolism, energy synthesis, and signal regulation.
Yanan Tan +6 more
doaj +2 more sources
The PHO pathway involved in phosphate metabolism in Yeast for efficient phosphorus removal
E3S Web of Conferences, 2018 Phosphorus is one of the essential elements needed for the growth and reproduction of any organism. To improve the efficiency of biological phosphorus removal in sewage, it is very important to grasp the precise mechanism of biological phosphorus removal.
Hu Mengfei, Qiu Liping, Wang Yan
doaj +2 more sources
The Pho regulon: a huge regulatory network in bacteria
Frontiers in Microbiology, 2015 One of the most important achievements of bacteria is its capability to adapt to the changing conditions of the environment. The competition for nutrients with other microorganisms, especially in the soil, where nutritional conditions are more variable ...
Fernando eSantos-Beneit
doaj +3 more sources
Core regulatory components of the PHO pathway are conserved in the methylotrophic yeast Hansenula polymorpha [PDF]
Current Genetics, 2016 Hiromi Maekawa +2 more
exaly +2 more sources
A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2017 Saccharomyces cerevisiae responds to changes in extracellular inorganic phosphate (Pi) availability by regulating the activity of the phosphate-responsive (PHO) signaling pathway, enabling cells to maintain intracellular levels of the essential nutrient ...
Joonhyuk Choi +4 more
doaj +1 more source
Molecules, 2022 Phosphorus in the form of phosphate (Pi) is an essential element for metabolic processes, including lipid metabolism. In yeast, the inositol polyphosphate kinase vip1 mediated synthesis of inositol heptakisphosphate (IP7) regulates the phosphate ...
Xueling Peng +7 more
doaj +1 more source
IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery
mBio, 2020 In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP7 (isomer 5-PP-IP5) in driving fungal virulence; however,
Desmarini Desmarini +11 more
doaj +1 more source
Anti-angiogenic and anti-metastatic activity of synthetic phosphoethanolamine. [PDF]
PLoS ONE, 2013 Renal cell carcinoma (RCC) is the most common type of kidney cancer, and represents the third most common urological malignancy. Despite the advent of targeted therapies for RCC and the improvement of the lifespan of patients, its cost-effectiveness ...
Adilson Kleber Ferreira +8 more
doaj +1 more source