Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host: A paradox explained by alkaline pH-simulated nutrient deprivation and expanded PHO pathway function. [PDF]
PLoS Pathogens, 2018 Sophie Lev, Julianne Teresa Djordjevic
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The PHO pathway involved in phosphate metabolism in Yeast for efficient phosphorus removal [PDF]
E3S Web of Conferences, 2018 Phosphorus is one of the essential elements needed for the growth and reproduction of any organism. To improve the efficiency of biological phosphorus removal in sewage, it is very important to grasp the precise mechanism of biological phosphorus removal.
Hu Mengfei, Qiu Liping, Wang Yan
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Core regulatory components of the PHO pathway are conserved in the methylotrophic yeast Hansenula polymorpha [PDF]
Current Genetics, 2016 To gain better understanding of the diversity and evolution of the gene regulation system in eukaryotes, the phosphate signal transduction (PHO) pathway in non-conventional yeasts has been studied in recent years. Here we characterized the PHO pathway of Hansenula polymorpha, which is genetically tractable and distantly related to Saccharomyces ...
Hiromi Maekawa +2 more
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Conservation of PHO pathway in ascomycetes and the role of Pho84
Journal of Biosciences, 2014 In budding yeast, Saccharomyces cerevisiae, the phosphate signalling and response pathway, known as PHO pathway, monitors phosphate cytoplasmic levels by controlling genes involved in scavenging, uptake and utilization of phosphate. Recent attempts to understand the phosphate starvation response in other ascomycetes have suggested the existence of both
Himanshu Sinha
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mBio, 2023 Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportunities.
Bethany Grace Bowring +10 more
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Multilayered Regulation of Fungal Phosphate Metabolism: From Molecular Mechanisms to Ecological Roles in the Global Phosphorus Cycle [PDF]
LifePhosphates are essential nutrients for living organisms, and they are involved in various biological processes, including lipid metabolism, energy synthesis, and signal regulation.
Yanan Tan +6 more
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PKA, PHO and stress response pathways regulate the expression of UDP-glucose pyrophosphorylase through Msn2/4 in budding yeast [PDF]
FEBS Letters, 2015 Ugp1, a UDP‐glucose pyrophosphorylase, is essential for various cellular activities in Saccharomyces cerevisiae because its product, UDP‐glucose, is a sole glucosyl donor in several metabolic pathways. Here, we report that Msn2/4 play a crucial role in the regulation of UGP1 expression.
Won-Ki Huh, Dae-Gwan Yi
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PLoS ONE, 2019 The phosphate sensing and acquisition (PHO) pathway of Cryptococcus neoformans is essential for growth in phosphate-limiting conditions and for dissemination of infection in a mouse model. Its key transcription factor, Pho4, regulates expression of genes
Sophie Lev +6 more
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A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2017 Saccharomyces cerevisiae responds to changes in extracellular inorganic phosphate (Pi) availability by regulating the activity of the phosphate-responsive (PHO) signaling pathway, enabling cells to maintain intracellular levels of the essential nutrient ...
Joonhyuk Choi +4 more
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