Results 11 to 20 of about 1,235,785 (183)

The Pho regulon: a huge regulatory network in bacteria [PDF]

Frontiers in Microbiology, 2015
One of the most important achievements of bacteria is its capability to adapt to the changing conditions of the environment. The competition for nutrients with other microorganisms, especially in the soil, where nutritional conditions are more variable ...
Fernando eSantos-Beneit
doaj   +2 more sources

VdNUC-2, the Key Regulator of Phosphate Responsive Signaling Pathway, Is Required for Verticillium dahliae Infection.

PLoS ONE, 2015
In fungal cells, a phosphate (Pi) responsive signaling and metabolism (PHO) pathway regulates Pi-homeostasis. NUC-2/PHO81 and its homologs are one of the most important components in the regulation pathway.
Sheng Deng, Cai-yue Wang, Xin Zhang, Qing Wang, Ling Lin   +4 more
doaj   +2 more sources

Sensing Inorganic Phosphate Starvation by the Phosphate-Responsive (PHO) Signaling Pathway of Saccharomyces cerevisiae [PDF]

, 2014
Inorganic phosphate \((P_i)\) is an essential nutrient whose intracellular levels are maintained by the PHO pathway in Saccharomyces cerevisiae.
Choi, Joonhyuk
core   +5 more sources

Phosphate Starvation by Energy Metabolism Disturbance in Candida albicansvip1Δ/Δ Induces Lipid Droplet Accumulation and Cell Membrane Damage

Molecules, 2022
Phosphorus in the form of phosphate (Pi) is an essential element for metabolic processes, including lipid metabolism. In yeast, the inositol polyphosphate kinase vip1 mediated synthesis of inositol heptakisphosphate (IP7) regulates the phosphate ...
Xueling Peng, Congcong Ma, Yuxin Feng, Biao Zhang, Mengsen Zhu, Tianyu Ma, Qilin Yu, Mingchun Li   +7 more
doaj   +1 more source

Intracellular Phosphate Serves as a Signal for the Regulation of the PHO Pathway in Saccharomyces cerevisiae [PDF]

Journal of Biological Chemistry, 2004
In Saccharomyces cerevisiae, the phosphate signal transduction pathway (PHO pathway) is known to regulate the expression of several phosphate-responsive genes, such as PHO5 and PHO84. However, the fundamental issue of whether cells sense intracellular or extracellular phosphate remains unresolved.
Choowong, Auesukaree, Tomoyuki, Homma, Hidehito, Tochio, Masahiro, Shirakawa, Yoshinobu, Kaneko, Satoshi, Harashima   +5 more
openaire   +2 more sources

IP₇-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

mBio, 2020
In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP7 (isomer 5-PP-IP5) in driving fungal virulence; however,
Desmarini Desmarini, Sophie Lev, David Furkert, Ben Crossett, Adolfo Saiardi, Keren Kaufman-Francis, Cecilia Li, Tania C. Sorrell, Lorna Wilkinson-White, Jacqueline Matthews, Dorothea Fiedler, Julianne Teresa Djordjevic   +11 more
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Anti-angiogenic and anti-metastatic activity of synthetic phosphoethanolamine. [PDF]

PLoS ONE, 2013
Renal cell carcinoma (RCC) is the most common type of kidney cancer, and represents the third most common urological malignancy. Despite the advent of targeted therapies for RCC and the improvement of the lifespan of patients, its cost-effectiveness ...
Adilson Kleber Ferreira, Vanessa Morais Freitas, Débora Levy, Jorge Luiz Mária Ruiz, Sergio Paulo Bydlowski, Rose Eli Grassi Rici, Otaviano Mendonça R Filho, Gilberto Orivaldo Chierice, Durvanei Augusto Maria   +8 more
doaj   +1 more source

Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

eLife, 2023
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert, Geun-Don Kim, Danye Qiu, Guizhen Liu, Lydie Michaillat Mayer, Muhammed Jamsheer K, Henning J Jessen, Andreas Mayer   +7 more
doaj   +1 more source

Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2 [PDF]

Journal of Bacteriology, 1995
Two pathways exist for cleavage of the carbon-phosphorus (C-P) bond of phosphonates, the C-P lyase and the phosphonatase pathways. It was previously demonstrated that Escherichia coli carries genes (named phn) only for the C-P lyase pathway and that Enterobacter aerogenes carries genes for both pathways (K.-S. Lee, W. W. Metcalf, and B. L.
W, Jiang, W W, Metcalf, K S, Lee, B L, Wanner   +3 more
openaire   +2 more sources

Nutrient-regulated antisense and intragenic RNAs modulate a signal transduction pathway in yeast. [PDF]

PLoS Biology, 2008
The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to a change in nutrient availability. The PHO system is a well-studied case in the transcriptional regulation responding to nutritional changes in which a set of ...
Masafumi Nishizawa, Tae Komai, Yuki Katou, Katsuhiko Shirahige, Takehiko Ito, Akio Toh-E   +5 more
doaj   +1 more source