Results 11 to 20 of about 7,818 (149)

The PHO signaling pathway directs lipid remodeling in Cryptococcus neoformans via DGTS synthase to recycle phosphate during phosphate deficiency.

PLoS ONE, 2019
The phosphate sensing and acquisition (PHO) pathway of Cryptococcus neoformans is essential for growth in phosphate-limiting conditions and for dissemination of infection in a mouse model. Its key transcription factor, Pho4, regulates expression of genes
Sophie Lev, Thusitha Rupasinghe, Desmarini Desmarini, Keren Kaufman-Francis, Tania Christine Sorrell, Ute Roessner, Julianne Teresa Djordjevic   +6 more
doaj   +5 more sources

Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

eLife, 2023
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert, Geun-Don Kim, Danye Qiu, Guizhen Liu, Lydie Michaillat Mayer, Muhammed Jamsheer K, Henning J Jessen, Andreas Mayer   +7 more
doaj   +1 more source

Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2 [PDF]

Journal of Bacteriology, 1995
Two pathways exist for cleavage of the carbon-phosphorus (C-P) bond of phosphonates, the C-P lyase and the phosphonatase pathways. It was previously demonstrated that Escherichia coli carries genes (named phn) only for the C-P lyase pathway and that Enterobacter aerogenes carries genes for both pathways (K.-S. Lee, W. W. Metcalf, and B. L.
W, Jiang, W W, Metcalf, K S, Lee, B L, Wanner   +3 more
openaire   +2 more sources

PKA, PHO and stress response pathways regulate the expression of UDP‐glucose pyrophosphorylase through Msn2/4 in budding yeast [PDF]

FEBS Letters, 2015
Ugp1, a UDP‐glucose pyrophosphorylase, is essential for various cellular activities in Saccharomyces cerevisiae because its product, UDP‐glucose, is a sole glucosyl donor in several metabolic pathways. Here, we report that Msn2/4 play a crucial role in the regulation of UGP1 expression.
Yi, Dae-Gwan, Huh, Won-Ki
openaire   +2 more sources

Nutrient-regulated antisense and intragenic RNAs modulate a signal transduction pathway in yeast. [PDF]

PLoS Biology, 2008
The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to a change in nutrient availability. The PHO system is a well-studied case in the transcriptional regulation responding to nutritional changes in which a set of ...
Masafumi Nishizawa, Tae Komai, Yuki Katou, Katsuhiko Shirahige, Takehiko Ito, Akio Toh-E   +5 more
doaj   +1 more source

The cardioprotection induced by lipopolysaccharide involves phos-phoinositide 3-kinase/Akt and high mobility group box 1 pathways [PDF]

Journal of Biomedical Research, 2010
The mechanisms by which lipopolysaccharide (LPS) pretreatment induces cardioprotection following ischaemia/reperfusion (I/R) have not been fully elucidated. We hypothesized that activation of phosphoinositide 3-kinase (PI3K)/Akt and high mobility group box 1 (HMGBx1) signaling plays an important role in LPS-induced cardioprotection.In in vivo ...
Liu, Xiang, Chen, Yijiang, Wu, Yanhu, Ha, Tuanzhu, Li, Chuanfu   +4 more
openaire   +3 more sources

VdNUC-2, the Key Regulator of Phosphate Responsive Signaling Pathway, Is Required for Verticillium dahliae Infection.

PLoS ONE, 2015
In fungal cells, a phosphate (Pi) responsive signaling and metabolism (PHO) pathway regulates Pi-homeostasis. NUC-2/PHO81 and its homologs are one of the most important components in the regulation pathway.
Sheng Deng, Cai-yue Wang, Xin Zhang, Qing Wang, Ling Lin   +4 more
doaj   +1 more source

Pho1a (plastid starch phosphorylase) is duplicated and essential for normal starch granule phenotype in tubers of Solanum tuberosum L

Frontiers in Plant Science, 2023
Reserve starch from seeds and tubers is a crucial plant product for human survival. Much research has been devoted to quantitative and qualitative aspects of starch synthesis and its relation to abiotic factors of importance in agriculture.
Shrikant Sharma, Martin Friberg, Paul Vogel, Helle Turesson, Niklas Olsson, Mariette Andersson, Per Hofvander   +6 more
doaj   +1 more source

Immunofluorescence can assess the efficacy of mTOR pathway therapeutic agent Everolimus in breast cancer models

Scientific Reports, 2019
When breast cancer patients start to exhibit resistance to hormonal therapy or chemotherapy, the mTOR inhibitor everolimus can be considered as an alternative therapeutic agent.
Chun-Ting Kuo, Chen-Lin Chen, Chih-Chi Li, Guan-Syuan Huang, Wei-Yuan Ma, Wei-Fan Hsu, Ching-Hung Lin, Yen-Shen Lu, Andrew M. Wo   +8 more
doaj   +1 more source

Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

mSphere, 2017
Phosphate acquisition by fungi is regulated by the phosphate-sensing and acquisition (PHO) signaling pathway. Cryptococcus neoformans disseminates from the lung to the brain and is the commonest cause of fungal meningitis worldwide.
Sophie Lev, Keren Kaufman-Francis, Desmarini Desmarini, Pierre G. Juillard, Cecilia Li, Sebastian A. Stifter, Carl G. Feng, Tania C. Sorrell, Georges E. R. Grau, Yong-Sun Bahn, Julianne T. Djordjevic   +10 more
doaj   +1 more source