Results 21 to 30 of about 1,235,785 (183)

The cardioprotection induced by lipopolysaccharide involves phos-phoinositide 3-kinase/Akt and high mobility group box 1 pathways [PDF]

Journal of Biomedical Research, 2010
The mechanisms by which lipopolysaccharide (LPS) pretreatment induces cardioprotection following ischaemia/reperfusion (I/R) have not been fully elucidated. We hypothesized that activation of phosphoinositide 3-kinase (PI3K)/Akt and high mobility group box 1 (HMGBx1) signaling plays an important role in LPS-induced cardioprotection.In in vivo ...
Liu, Xiang, Chen, Yijiang, Wu, Yanhu, Ha, Tuanzhu, Li, Chuanfu   +4 more
openaire   +3 more sources

Immunofluorescence can assess the efficacy of mTOR pathway therapeutic agent Everolimus in breast cancer models

Scientific Reports, 2019
When breast cancer patients start to exhibit resistance to hormonal therapy or chemotherapy, the mTOR inhibitor everolimus can be considered as an alternative therapeutic agent.
Chun-Ting Kuo, Chen-Lin Chen, Chih-Chi Li, Guan-Syuan Huang, Wei-Yuan Ma, Wei-Fan Hsu, Ching-Hung Lin, Yen-Shen Lu, Andrew M. Wo   +8 more
doaj   +1 more source

Pho1a (plastid starch phosphorylase) is duplicated and essential for normal starch granule phenotype in tubers of Solanum tuberosum L

Frontiers in Plant Science, 2023
Reserve starch from seeds and tubers is a crucial plant product for human survival. Much research has been devoted to quantitative and qualitative aspects of starch synthesis and its relation to abiotic factors of importance in agriculture.
Shrikant Sharma, Martin Friberg, Paul Vogel, Helle Turesson, Niklas Olsson, Mariette Andersson, Per Hofvander   +6 more
doaj   +1 more source

Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

mSphere, 2017
Phosphate acquisition by fungi is regulated by the phosphate-sensing and acquisition (PHO) signaling pathway. Cryptococcus neoformans disseminates from the lung to the brain and is the commonest cause of fungal meningitis worldwide.
Sophie Lev, Keren Kaufman-Francis, Desmarini Desmarini, Pierre G. Juillard, Cecilia Li, Sebastian A. Stifter, Carl G. Feng, Tania C. Sorrell, Georges E. R. Grau, Yong-Sun Bahn, Julianne T. Djordjevic   +10 more
doaj   +1 more source

Phosphate Acquisition and Virulence in Human Fungal Pathogens

Microorganisms, 2017
The ability of pathogenic fungi to acquire essential macro and micronutrients during infection is a well-established virulence trait. Recent studies in the major human fungal pathogens Candida albicans and Cryptococcus neoformans have revealed that ...
Mélanie Ikeh, Yasmin Ahmed, Janet Quinn
doaj   +1 more source

Androgen receptor knockdown enhances prostate cancer chemosensitivity by down‐regulating FEN1 through the ERK/ELK1 signalling pathway

Cancer Medicine, 2023
Purpose Flap endonuclease 1 (FEN1) is highly upregulated in prostate cancer and promotes the growth of prostate cancer cells. Androgen receptor (AR) is the most critical determinant of the occurrence, progression, metastasis, and treatment of prostate ...
Weijie Xie, Shulin Li, Huan Guo, Jiawei Zhang, Menjiang Tu, Rui Wang, Bingling Lin, Yuqi Wu, Xiangwei Wang   +8 more
doaj   +1 more source

Regulation of autophagy and lipid accumulation under phosphate limitation in Rhodotorula toruloides

Frontiers in Microbiology, 2023
BackgroundIt is known that autophagy is essential for cell survival under stress conditions. Inorganic phosphate (Pi) is an essential nutrient for cell growth and Pi-limitation can trigger autophagy and lipid accumulation in oleaginous yeasts, yet ...
Ya-nan Wang, Ya-nan Wang, Fang-jie Liu, Hong-di Liu, Yue Zhang, Xiang Jiao, Ming-liang Ye, Ming-liang Ye, Zong-bao Kent Zhao, Zong-bao Kent Zhao, Su-fang Zhang, Su-fang Zhang   +11 more
doaj   +1 more source

Towards the integration of computational systems biology and high-throughput data: supporting differential analysis of microarray gene expression data

Journal of Integrative Bioinformatics, 2008
The paradigmatic shift occurred in biology that led first to high-throughput experimental techniques and later to computational systems biology must be applied also to the analysis paradigm of the relation between local models and data to obtain an ...
Segata Nicola, Blanzieri Enrico, Priami Corrado   +2 more
doaj   +2 more sources

A transcriptional activator from Rhizophagus irregularis regulates phosphate uptake and homeostasis in AM symbiosis during phosphorous starvation

Frontiers in Microbiology, 2023
IntroductionPhosphorus (P) is one of the most important nutrient elements for plant growth and development. Under P starvation, arbuscular mycorrhizal (AM) fungi can promote phosphate (Pi) uptake and homeostasis within host plants.
Shuyuan Zhang, Yuying Nie, Xiaoning Fan, Wei Wei, Hui Chen, Xianan Xie, Ming Tang   +6 more
doaj   +1 more source

Exposure to nanopolystyrene and phoxim at ambient concentrations causes oxidative stress and inflammation in the intestines of the Chinese mitten crab (Eriocheir sinensis)

Ecotoxicology and Environmental Safety
Nanopolystyrene (NP) and phoxim (PHO) are common environmental pollutants in aquatic systems. We evaluated the toxic effects of exposure to ambient concentrations of NP and/or PHO in the intestines of the Chinese mitten crab (Eriocheir sinensis).
Shunli Che, Mengting Huang, Lemei Zhu, Longteng Shen, Yuan Ma, Zhicheng Wan, Xuguang Li, Jun Zhou, Shuquan Ding, Xilei Li   +9 more
doaj   +1 more source