Results 21 to 30 of about 7,818 (149)

Androgen receptor knockdown enhances prostate cancer chemosensitivity by down‐regulating FEN1 through the ERK/ELK1 signalling pathway

Cancer Medicine, 2023
Purpose Flap endonuclease 1 (FEN1) is highly upregulated in prostate cancer and promotes the growth of prostate cancer cells. Androgen receptor (AR) is the most critical determinant of the occurrence, progression, metastasis, and treatment of prostate ...
Weijie Xie, Shulin Li, Huan Guo, Jiawei Zhang, Menjiang Tu, Rui Wang, Bingling Lin, Yuqi Wu, Xiangwei Wang   +8 more
doaj   +1 more source

Regulation of autophagy and lipid accumulation under phosphate limitation in Rhodotorula toruloides

Frontiers in Microbiology, 2023
BackgroundIt is known that autophagy is essential for cell survival under stress conditions. Inorganic phosphate (Pi) is an essential nutrient for cell growth and Pi-limitation can trigger autophagy and lipid accumulation in oleaginous yeasts, yet ...
Ya-nan Wang, Ya-nan Wang, Fang-jie Liu, Hong-di Liu, Yue Zhang, Xiang Jiao, Ming-liang Ye, Ming-liang Ye, Zong-bao Kent Zhao, Zong-bao Kent Zhao, Su-fang Zhang, Su-fang Zhang   +11 more
doaj   +1 more source

Phosphate Acquisition and Virulence in Human Fungal Pathogens

Microorganisms, 2017
The ability of pathogenic fungi to acquire essential macro and micronutrients during infection is a well-established virulence trait. Recent studies in the major human fungal pathogens Candida albicans and Cryptococcus neoformans have revealed that ...
Mélanie Ikeh, Yasmin Ahmed, Janet Quinn
doaj   +1 more source

Towards the integration of computational systems biology and high-throughput data: supporting differential analysis of microarray gene expression data

Journal of Integrative Bioinformatics, 2008
The paradigmatic shift occurred in biology that led first to high-throughput experimental techniques and later to computational systems biology must be applied also to the analysis paradigm of the relation between local models and data to obtain an ...
Segata Nicola, Blanzieri Enrico, Priami Corrado   +2 more
doaj   +2 more sources

A transcriptional activator from Rhizophagus irregularis regulates phosphate uptake and homeostasis in AM symbiosis during phosphorous starvation

Frontiers in Microbiology, 2023
IntroductionPhosphorus (P) is one of the most important nutrient elements for plant growth and development. Under P starvation, arbuscular mycorrhizal (AM) fungi can promote phosphate (Pi) uptake and homeostasis within host plants.
Shuyuan Zhang, Yuying Nie, Xiaoning Fan, Wei Wei, Hui Chen, Xianan Xie, Ming Tang   +6 more
doaj   +1 more source

Catalytic Enantioselective Multicomponent Reactions of Sulfoxonium Ylides Enabled by a Formal Rearrangement—A Versatile Entry to Enantioenriched α‐Sulfanyl Carbonyl Compounds

Angewandte Chemie, EarlyView.
A catalytic network embedding a formal rearrangement enables the first catalytic enantioselective multicomponent reaction (MCR) of sulfur ylides. In the presence of a bulky chiral phosphoric acid, the reaction combines sulfoxonium ylides, aldehydes and thiols, and affords synthetically versatile β‐hydroxy‐α‐sulfanyl carbonyl compounds in ...
Nicolò Santarelli, Pietro Pecchini, Nunzio Matera, Andrea Pellegrini, Riccardo Fabbri, Irati Celada Cubero, Leire Navarro Rubio, Cristina Di Pietro, Andrea Mazzanti, Mariafrancesca Fochi, Luca Bernardi   +10 more
wiley   +2 more sources

Exposure to nanopolystyrene and phoxim at ambient concentrations causes oxidative stress and inflammation in the intestines of the Chinese mitten crab (Eriocheir sinensis)

Ecotoxicology and Environmental Safety
Nanopolystyrene (NP) and phoxim (PHO) are common environmental pollutants in aquatic systems. We evaluated the toxic effects of exposure to ambient concentrations of NP and/or PHO in the intestines of the Chinese mitten crab (Eriocheir sinensis).
Shunli Che, Mengting Huang, Lemei Zhu, Longteng Shen, Yuan Ma, Zhicheng Wan, Xuguang Li, Jun Zhou, Shuquan Ding, Xilei Li   +9 more
doaj   +1 more source

Genome-Wide Characterization of the Phosphate Starvation Response in Schizosaccharomyces pombe

BMC Genomics, 2012
Background Inorganic phosphate is an essential nutrient required by organisms for growth. During phosphate starvation, Saccharomyces cerevisiae activates the phosphate signal transduction (PHO) pathway, leading to expression of the secreted acid ...
Carter-O’Connell Ian, Peel Michael T, Wykoff Dennis D, O’Shea Erin K   +3 more
doaj   +1 more source

Proteome Expression and Survival Strategies of a Proteorhodopsin-Containing Vibrio Strain under Carbon and Nitrogen Limitation

mSystems, 2022
Photoheterotrophy is a widespread mode of microbial metabolism, notably in the oligotrophic surface ocean, where microbes experience chronic nutrient limitation.
Gwendolyn E. Gallagher, Jacob R. Waldbauer   +1 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source