Results 31 to 40 of about 2,579,257 (273)

Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in Cryptococcus neoformans

mBio, 2023
Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportunities.
Bethany Grace Bowring, Pooja Sethiya, Desmarini Desmarini, Sophie Lev, Lisa Tran Le, Yong-Sun Bahn, Seung-Heon Lee, Akio Toh-e, Nicholas Proschogo, Tom Savage, Julianne Teresa Djordjevic   +10 more
doaj   +1 more source

The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe

Journal of Fungi, 2021
Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds.
Marina Pascual-Ortiz, Eva Walla, Ursula Fleig, Adolfo Saiardi   +3 more
doaj   +1 more source

Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

eLife, 2023
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert, Geun-Don Kim, Danye Qiu, Guizhen Liu, Lydie Michaillat Mayer, Muhammed Jamsheer K, Henning J Jessen, Andreas Mayer   +7 more
doaj   +1 more source

The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective

Frontiers in Endocrinology, 2020
The Carbohydrate response element binding protein, ChREBP encoded by the MLXIPL gene, is a transcription factor that is expressed at high levels in the liver and has a prominent function during consumption of high-carbohydrate diets.
Loranne Agius, Shruti S. Chachra, Brian E. Ford   +2 more
doaj   +1 more source

Genetic evidence of serum phosphate-independent functions of FGF-23 on bone.

PLoS Genetics, 2008
Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization.
Despina Sitara, Somi Kim, Mohammed S Razzaque, Clemens Bergwitz, Takashi Taguchi, Christiane Schüler, Reinhold G Erben, Beate Lanske   +7 more
doaj   +1 more source

Phosphate Acquisition and Virulence in Human Fungal Pathogens

Microorganisms, 2017
The ability of pathogenic fungi to acquire essential macro and micronutrients during infection is a well-established virulence trait. Recent studies in the major human fungal pathogens Candida albicans and Cryptococcus neoformans have revealed that ...
Mélanie Ikeh, Yasmin Ahmed, Janet Quinn
doaj   +1 more source

Salivary phosphate as a biomarker for human diseases

FASEB BioAdvances, 2022
Phosphate is a common ingredient of the daily consumed foods and is absorbed in the intestine and is excreted in the urine through the kidney to maintain the homeostatic balance.
Mohammed S. Razzaque
doaj   +1 more source

Emerging roles of long non-coding RNA in root developmental plasticity and regulation of phosphate homeostasis

Frontiers in Plant Science, 2015
Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression in a variety of biological process and in multiple species. In plants, they are transcribed by different RNA polymerases and show diverse structural features. With the
Jérémie eBazin, Jérémie eBazin, Julia eBailey-Serres   +2 more
doaj   +1 more source

Interaction and Regulation of Carbon, Nitrogen, and Phosphorus Metabolisms in Root Nodules of Legumes

Frontiers in Plant Science, 2018
Members of the plant family Leguminosae (Fabaceae) are unique in that they have evolved a symbiotic relationship with rhizobia (a group of soil bacteria that can fix atmospheric nitrogen).
Ailin Liu, Ailin Liu, Carolina A. Contador, Carolina A. Contador, Kejing Fan, Kejing Fan, Hon-Ming Lam, Hon-Ming Lam   +7 more
doaj   +1 more source

Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast

mBio, 2022
Inositol pyrophosphate (IPP) dynamics govern expression of the fission yeast phosphate homeostasis regulon via their effects on lncRNA-mediated transcription interference.
Beate Schwer, Angad Garg, Ana M. Sanchez, Mindy A. Bernstein, Bradley Benjamin, Stewart Shuman   +5 more
doaj   +1 more source