Results 31 to 40 of about 642,082 (258)

Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-ꞵ signaling

iScience
Summary: One of the main regulators of phosphate homeostasis is fibroblast growth factor 23 (FGF23), secreted by osteocytes. The effects of organic versus inorganic dietary phosphate on this homeostasis are unclear.
Danielle M.A. Ratsma, Max Muller, Marijke Koedam, Johannes P.T.M. van Leeuwen, M. Carola Zillikens, Bram C.J. van der Eerden   +5 more
doaj   +1 more source

A novel role for the root cap in phosphate uptake and homeostasis

eLife, 2016
The root cap has a fundamental role in sensing environmental cues as well as regulating root growth via altered meristem activity. Despite this well-established role in the control of developmental processes in roots, the root cap’s function in nutrition
Satomi Kanno, Jean-François Arrighi, Serge Chiarenza, Vincent Bayle, Richard Berthomé, Benjamin Péret, Hélène Javot, Etienne Delannoy, Elena Marin, Tomoko M Nakanishi, Marie-Christine Thibaud, Laurent Nussaume   +11 more
doaj   +1 more source

Molecular regulators of phosphate homeostasis in plants [PDF]

Journal of Experimental Botany, 2009
An appropriate cellular phosphate (Pi) concentration is indispensable for essential physiological and biochemical processes. To maintain cellular Pi homeostasis, plants have developed a series of adaptive responses to facilitate external Pi acquisition and to limit Pi consumption and to adjust Pi recycling internally when the Pi supply is inadequate ...
Wei-Yi, Lin, Shu-I, Lin, Tzyy-Jen, Chiou
openaire   +2 more sources

The ins and outs of phosphate homeostasis [PDF]

Kidney International, 2007
A complication of chronic renal failure is hyperphosphatemia. An apparently straightforward manipulation to treat this--restriction of dietary phosphate--has proven that phosphate homeostasis is more complicated than we currently understand. This Commentary describes recent findings on novel regulatory factors that contribute to phosphate homeostasis.
openaire   +2 more sources

pH homeostasis in yeast; the phosphate perspective [PDF]

Current Genetics, 2017
Recent research further clarified the molecular mechanisms that link nutrient signaling and pH homeostasis with the regulation of growth and survival of the budding yeast Saccharomyces cerevisiae. The central nutrient signaling kinases PKA, TORC1, and Sch9 are intimately associated to pH homeostasis, presumably allowing them to concert far-reaching ...
Eskes, Elja, Deprez, Marie-Anne, Wilms, Tobias, Winderickx, Joris   +3 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mobilization and Cellular Distribution of Phosphate in the Diatom Phaeodactylum tricornutum

Frontiers in Plant Science, 2020
Unicellular organisms that live in marine environments must cope with considerable fluctuations in the availability of inorganic phosphate (Pi). Here, we investigated the extracellular Pi concentration-dependent expression, as well as the intracellular ...
Gianluca Dell’Aquila, Stefan Zauner, Thomas Heimerl, Jörg Kahnt, Vera Samel-Gondesen, Simon Runge, Franziska Hempel, Uwe G. Maier, Uwe G. Maier   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source