A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis. [PDF]
Nat CommunInositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenger 1,5-InsP8, the C-terminal phosphatase domain catalyzes PP-InsP breakdown ...
Raia P +9 more
europepmc +7 more sources
The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in <i>S. pombe</i>. [PDF]
J Fungi (Basel), 2021 Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds.
Pascual-Ortiz M +3 more
europepmc +7 more sources
Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Central carbon metabolism has the overlapping functions of converting substrate into biomass and the extraction and storage of chemical energy. These metabolic pathways are rewired by cancer cells to selectively support increased biomass demands.
Gu C +7 more
europepmc +5 more sources
Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? [PDF]
Molecules, 2020 The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Cridland C, Gillaspy G.
europepmc +4 more sources
Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals. [PDF]
Molecules, 2020 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Lee S, Kim MG, Ahn H, Kim S.
europepmc +4 more sources
Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7. [PDF]
Biomolecules, 2023 Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
Sahu S +6 more
europepmc +2 more sources
Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in <i>S. pombe</i>. [PDF]
J Fungi (Basel), 2022 Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Kuenzel NA +6 more
europepmc +2 more sources
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment [PDF]
Bioscience Reports, 2013 Diphosphoinositol polyphosphates ( PP ‐Ins P s) link nutrient status to the regulation of cellular growth and energy homeostasis; PP Ins P turnover may impact bioenergetic ...
Huanchen Wang +2 more
exaly +3 more sources
Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development. [PDF]
PLoS GenetInositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Laurent F +10 more
europepmc +2 more sources
A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. [PDF]
PLoS One, 2016 Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches.
Baughman BM +8 more
europepmc +2 more sources