A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis [PDF]
Nature CommunicationsInositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenger 1,5-InsP8, the C-terminal phosphatase domain catalyzes PP-InsP breakdown ...
Dorothea Fiedler +2 more
exaly +12 more sources
The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe [PDF]
Journal of Fungi, 2021 Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds.
Marina Pascual-Ortiz +3 more
doaj +7 more sources
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment [PDF]
Bioscience Reports, 2013 We obtained detailed kinetic characteristics–stoichiometry, reaction rates, substrate affinities and equilibrium conditions–of human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). This enzyme synthesizes ‘high-energy’
Stephen B Shears, Huanchen Wang
exaly +6 more sources
Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Central carbon metabolism has the overlapping functions of converting substrate into biomass and the extraction and storage of chemical energy. These metabolic pathways are rewired by cancer cells to selectively support increased biomass demands.
Ji Luo, Stephen B Shears, Xiaojing Liu
exaly +5 more sources
Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7 [PDF]
Biomolecules, 2023 Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
Soumyadip Sahu +6 more
doaj +3 more sources
Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe [PDF]
Journal of Fungi, 2022 Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Natascha Andrea Kuenzel +6 more
doaj +4 more sources
Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? [PDF]
Molecules, 2020 The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Glenda Gillaspy, Caitlin Cridland
exaly +4 more sources
Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates. [PDF]
FEBS LettInositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Rolfes RJ.
europepmc +2 more sources
Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. [PDF]
Chemistry, 2023 How do pyrophosphate analogs compare? The synthesis of a fluorinated analog of an inositol pyrophosphate messenger is reported. Comparison of the physicochemical and biochemical properties of a range of closely related analogs showcases that subtle modifications can distinctly influence the behavior of molecules.
Hostachy S +8 more
europepmc +2 more sources
Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies. [PDF]
Adv Sci (Weinh)Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Saiardi A +5 more
europepmc +2 more sources