A two-way switch for inositol pyrophosphate signaling: Evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase. [PDF]
Adv Biol Regul, 2020 The inositol pyrophosphates (PP-InsPs) are a unique subgroup of intracellular signals with diverse functions, many of which can be viewed as reflecting an overarching role in metabolic homeostasis. Thus, considerable attention is paid to the enzymes that
Randall TA +4 more
europepmc +2 more sources
Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?
Plants, 2020 Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed +2 more
doaj +1 more source
Potential therapies targeting nuclear metabolic regulation in cancer
MedComm, Volume 4, Issue 6, December 2023., 2023 1. Cell metabolism and gene control are significantly integrated and regulated by one another. 2. There is a positive feedback loop of metabolism‐epigenetics‐gene regulation which control cancer progression. 3. The discovery of metabolic enzymes and their functions in the nucleus will provide more insights into cancer therapy.
Yanjie Chen +5 more
wiley +1 more source
New Phytologist, Volume 232, Issue 5, Page 2011-2025, December 2021., 2021 Summary Stress and nutrient availability influence cell proliferation through complex intracellular signalling networks. In a previous study it was found that pyro‐inositol polyphosphates (InsP7 and InsP8) produced by VIP1 kinase, and target of rapamycin (TOR) kinase signalling interacted synergistically to control cell growth and lipid metabolism in ...
Inmaculada Couso +5 more
wiley +1 more source
The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis [PDF]
Journal of Biological Chemistry, 2017 Proteins responsible for Pi homeostasis are critical for all life. In Saccharomyces cerevisiae, extracellular [Pi] is “sensed” by the inositol-hexakisphosphate kinase (IP6K) that synthesizes the intracellular inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP7) as follows: during a period of Pi starvation, there is a decline
Gu, Chunfang +6 more
openaire +4 more sources
The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis [PDF]
, 2021 Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP6 also known as Phytic acid) present in the amoeba allowed the discovery of the more ...
Jessen, HJ +8 more
core +1 more source
The dead phosphatases society: a review of the emerging roles of pseudophosphatases
The FEBS Journal, Volume 287, Issue 19, Page 4198-4220, October 2020., 2020 Phosphatases are signaling enzymes that remove phosphate from proteins, lipids and other cellular components. A significant fraction of the human phosphatases bear mutations in one or several catalytic motifs. These members are referred to as pseudophosphatases and are present in most subfamilies of the phosphatome.
Veronika Reiterer +5 more
wiley +1 more source
Caenorhabditis elegans phosphatase complexes in UniProtKB and Complex Portal
The FEBS Journal, Volume 287, Issue 13, Page 2664-2684, July 2020., 2020 The UniProt Knowledgebase (UniProtKB) and Complex Portal databases facilitate the understanding of how protein phosphorylation is regulated by providing structural and functional information on phosphatase‐containing macromolecular complexes across a wide range of species.
Hema Bye‐A‐Jee +4 more
wiley +1 more source
Identity and functions of inorganic and inositol polyphosphates in plants
New Phytologist, Volume 225, Issue 2, Page 637-652, January 2020., 2020 Summary Inorganic polyphosphates (polyPs) and inositol pyrophosphates (PP‐InsPs) form important stores of inorganic phosphate and can act as energy metabolites and signaling molecules. Here we review our current understanding of polyP and inositol phosphate (InsP) metabolism and physiology in plants.
Laura Lorenzo‐Orts +2 more
wiley +1 more source
Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7. [PDF]
, 2023 Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
core +6 more sources