Results 21 to 30 of about 306 (116)

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +1 more source

Potential therapies targeting nuclear metabolic regulation in cancer

MedComm, Volume 4, Issue 6, December 2023., 2023
1. Cell metabolism and gene control are significantly integrated and regulated by one another. 2. There is a positive feedback loop of metabolism‐epigenetics‐gene regulation which control cancer progression. 3. The discovery of metabolic enzymes and their functions in the nucleus will provide more insights into cancer therapy.
Yanjie Chen, Jie Xu, Xiaoyi Liu, Linlin Guo, Ping Yi, Chunming Cheng   +5 more
wiley   +1 more source

Inositol polyphosphates and target of rapamycin kinase signalling govern photosystem II protein phosphorylation and photosynthetic function under light stress in Chlamydomonas

New Phytologist, Volume 232, Issue 5, Page 2011-2025, December 2021., 2021
Summary Stress and nutrient availability influence cell proliferation through complex intracellular signalling networks. In a previous study it was found that pyro‐inositol polyphosphates (InsP7 and InsP8) produced by VIP1 kinase, and target of rapamycin (TOR) kinase signalling interacted synergistically to control cell growth and lipid metabolism in ...
Inmaculada Couso, Amanda L. Smythers, Megan M. Ford, James G. Umen, José L. Crespo, Leslie M. Hicks   +5 more
wiley   +1 more source

Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Plants, 2020
Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed, Olusegun Adepoju, Glenda Gillaspy   +2 more
doaj   +1 more source

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis

BMC Biology, 2021
Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla, Mandeep Kaur, Swati Kanwar, Gazaldeep Kaur, Shivani Sharma, Shubhra Ganguli, Vandana Kumari, Koushik Mazumder, Pratima Pandey, Hatem Rouached, Vikas Rishi, Rashna Bhandari, Ajay Kumar Pandey   +12 more
doaj   +1 more source

Development of a Virtual Screening Pipeline for the Identification of Small Molecule PPIP5K2 Inhibitors [PDF]

, 2021
Phosphate homeostasis is essential for survival in eucaryotes. It is mediated by inositol phosphates, which are synthesized by a sequence of kinases. One such kinase in humans is diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2).
Leja, Mareike
core   +1 more source

The dead phosphatases society: a review of the emerging roles of pseudophosphatases

The FEBS Journal, Volume 287, Issue 19, Page 4198-4220, October 2020., 2020
Phosphatases are signaling enzymes that remove phosphate from proteins, lipids and other cellular components. A significant fraction of the human phosphatases bear mutations in one or several catalytic motifs. These members are referred to as pseudophosphatases and are present in most subfamilies of the phosphatome.
Veronika Reiterer, Krzysztof Pawłowski, Guillaume Desrochers, Arnim Pause, Hayley J. Sharpe, Hesso Farhan   +5 more
wiley   +1 more source

Caenorhabditis elegans phosphatase complexes in UniProtKB and Complex Portal

The FEBS Journal, Volume 287, Issue 13, Page 2664-2684, July 2020., 2020
The UniProt Knowledgebase (UniProtKB) and Complex Portal databases facilitate the understanding of how protein phosphorylation is regulated by providing structural and functional information on phosphatase‐containing macromolecular complexes across a wide range of species.
Hema Bye‐A‐Jee, Rossana Zaru, Michele Magrane, Sandra Orchard, the UniProt Consortium   +4 more
wiley   +1 more source

Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis [PDF]

, 2018
Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to ...
Alcazar-Roman, Alexova, Auesukaree, Aung, Azevedo, Azevedo, Bari, Berridge, Boer, Bosch, Brearley, Brearley, Brearley, Brearley, Chamberlain, Chiou, Chiou, Cho, Choi, Clough, Curtis, Desai, Duff, Franco-Zorrilla, Gonzalez, Hammond, Hanke, Ho, Holford, Huang, Huang, Irvine, Kanehara, Karimi, Kim, Kuo, Kusano, Laha, Lee, Lee, Lee, Lemtiri-Chlieh, Lemtiri-Chlieh, Lin, Lin, Lin, Liu, Liu, Liu, Lonetti, Martin, Mosblech, Mulugu, Munnik, Munnik, Munnik, Murphy, Müller, Nagy, Norbis, Pant, Perera, Perera, Perera, Phillippy, Pradet, Puga, Raboy, Raboy, Rao, Rouached, Saiardi, Saiardi, Saiardi, Schell, Schneider, Secco, Secco, Shears, Stenzel, Stephens, Stephens, Stevenson-Paulik, Stevenson-Paulik, Sweetman, Szijgyarto, Torabinejad, Vajanaphanich, Voglmaier, Wang, Whiteford, Wild, Williams, Wilson, Wreggett, Wu, Wu, Wundenberg, Xiong, Xu, Xu, Yang, Yang, York, Zonia   +104 more
core   +2 more sources

Identity and functions of inorganic and inositol polyphosphates in plants

New Phytologist, Volume 225, Issue 2, Page 637-652, January 2020., 2020
Summary Inorganic polyphosphates (polyPs) and inositol pyrophosphates (PP‐InsPs) form important stores of inorganic phosphate and can act as energy metabolites and signaling molecules. Here we review our current understanding of polyP and inositol phosphate (InsP) metabolism and physiology in plants.
Laura Lorenzo‐Orts, Daniel Couto, Michael Hothorn   +2 more
wiley   +1 more source