Inositol phosphate pathway evolution and synthesis in Dictyostelium discoideum [PDF]
, 2020 Inositol phosphates (InsPs) are polar water-soluble derivatives of the six- carbon cyclitol inositol. They are synthesized, through phosphorylation reactions, by kinases of four distinct families: IPK, IP5-2K, ITPK1 and PPIP5K, which are thought to be ...
Portela Torres, Paloma
core
Genome editing and cancer: How far has research moved forward on CRISPR/Cas9? [PDF]
, 2022 Financiado para publicación en acceso aberto: Universidade de Vigo/CISUGCancer accounted for almost ten million deaths worldwide in 2020. Metastasis, characterized by cancer cell invasion to other parts of the body, is the main cause of cancer morbidity ...
Alshahrani, Asma M. +10 more
core +1 more source
One scaffold, two conformations: the ring-flip of the messenger InsP8 occurs under cytosolic conditions [PDF]
, 2023 Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are central eukaryotic messengers. These very highly phosphorylated molecules can exist in two distinct conformations, a canonical one with five phosphoryl groups in equatorial positions, and a ...
core +1 more source
CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy
VIEW, Volume 6, Issue 5, October 2025.The recent advancements in the application of CRISPR/Cas9‐edited tumor‐associated immune cells in cancer therapy are summarized, including T lymphoid cells, natural killer cells, macrophages, and B lymphoid cells et al., exhibiting a potential impact on the pathological status of cancer. This review also addresses the current challenges associated with
Yuhui Ma +6 more
wiley +1 more source
Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling [PDF]
, 2017 Inositol polyphosphates, in their water-soluble or lipid-bound forms, represent a large and multifaceted family of signalling molecules. Some inositol polyphosphates are well recognised as defining important signal transduction pathways, as in the case ...
Saiardi, A, Wilson, MSC
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Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry [PDF]
, 2020 The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible isomers, the absence of a chromophore, the high charge density, the low abundance, and the instability ...
Eisenbeis, VB +14 more
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Application of CRISPR-Cas9 gene editing technology in basic research, diagnosis and treatment of colon cancer [PDF]
, 2023 Colon cancer is the fourth leading cause of cancer death worldwide, and its progression is accompanied by a complex array of genetic variations. CRISPR/Cas9 can identify new drug-resistant or sensitive mutations in colon cancer, and can use gene editing ...
Hui Meng +5 more
core +1 more source
The Plant Journal, Volume 123, Issue 1, July 2025.SUMMARY Phosphate (Pi) is a critical nutrient for plants and is often a limiting factor in food production, as many agricultural soils are limited in available Pi. Inositol pyrophosphates (PP‐InsPs) are signaling molecules involved in Pi sensing and jasmonic acid (JA)‐regulated plant defense. Here, we report that overexpression of 1,3,4‐trisphosphate 5/
Caitlin Cridland +7 more
wiley +1 more source
First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase [PDF]
, 2012 We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP5 mimics 5-PP-InsP 5 binding to the kinase domain of PPIP5K2;
Potter, BVL +4 more
core +2 more sources
Chemical tools to investigate inositol pyrophosphate protein interactions [PDF]
, 2023 Die Inositol-Pyrophosphate (PP-InsPs) sind eine ubiquitäre Gruppe hochphosphorylierter eukaryotischer Signalmoleküle. Sie werden mit einer Vielzahl zentraler zellulärer Prozesse in Verbindung gebracht, doch fehlt oft ein detailliertes Verständnis der ...
Furkert, David
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