Results 41 to 50 of about 261 (97)
Schematic depicting the three phases of the HTS Assay for PPIP5K.
, 2016 The schematic describes how the degree of PPIP5K activity is inversely proportional to the magnitude of the HTRF signal. During the kinase reaction 5-InsP7 phosphorylation to 1,5-InsP8 is coupled to ATP conversion to ADP.
Huanchen Wang (1500046) +8 more
core +1 more source
The Plant Journal, Volume 123, Issue 1, July 2025.SUMMARY Phosphate (Pi) is a critical nutrient for plants and is often a limiting factor in food production, as many agricultural soils are limited in available Pi. Inositol pyrophosphates (PP‐InsPs) are signaling molecules involved in Pi sensing and jasmonic acid (JA)‐regulated plant defense. Here, we report that overexpression of 1,3,4‐trisphosphate 5/
Caitlin Cridland +7 more
wiley +1 more source
Synthetic Inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery [PDF]
, 2017 SummaryDiphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) is one of the mammalian PPIP5K isoforms responsible for synthesis of diphosphoinositol polyphosphates (inositol pyrophosphates; PP-InsPs), regulatory molecules that function at the interface ...
core +1 more source
Structures and dose-response relationships for three inhibitors of PPIP5Ks.
, 2016 Structures for (A) UNC10112646 (B) UNC10225354 and (C) UNC10225498 (D) Dose-response curves for the inhibition of PPIP5K by UNC10225354 (IC50 = 5.24 ± 0.18 μM), UNC10225498 (IC50 = 2.14 ± 0.07 μM), and UNC10112646 (IC50 = 6.96 ± 0.03 μM).
Huanchen Wang (1500046) +8 more
core +1 more source
When worlds collide: inositol pyrophosphates and phosphoinositides intersect at the plasma membrane.
, 2013 Highly phosphorylated inositol pyrophosphates are present in the cells of many organisms such as yeast, Dictyostelium and mammals. They can act as signal molecules in growth factor and insulin signalling both in cultured cells and in intact mice.
Elong Edimo, William's +1 more
core +1 more source
Species Context Reverses PPIP5K Control of Fungal Morphogenesis and Actin Organization
Inositol pyrophosphates are conserved signaling molecules synthesized by the bifunctional PPIP5K enzymes, but how their cellular functions diversify across species remains poorly understood.
Dorothea Fiedler +13 more
core +1 more source
The docking poses of UNC10225498 and UNC10112646 with PPIP5K.
, 2016 (A) UNC10225498 (thick sticks; orange carbons) (B) UNC10112646 (thick sticks; green carbons). The ATP pocket is outlined as a gray transparent surface and ATP itself is depicted by thin magenta sticks. Residues predicted to interact with docked compounds
Huanchen Wang (1500046) +8 more
core +1 more source
HTS of PPIP5K against a kinase-focused library of potential nucleotide antagonists.
, 2016 (A) Representative technical replicates measured on the same day. (B) Comparison of the mean values of biological replicates (black and white circles) obtained on two different days. R2 = 0.99.
Huanchen Wang (1500046) +8 more
core +1 more source
Role of transporters in regulating mammalian intracellular inorganic phosphate. [PDF]
Front Pharmacol, 2023 Jennings ML.
europepmc +1 more source
, 2016 (A) UNC10225498; Kd = 1.37 ± 0.03 μM (B) UNC10112646; Kd = 7.30 ± 0.03 μM. Representative data are shown.
Huanchen Wang (1500046) +8 more
core +1 more source