Results 61 to 70 of about 306 (116)

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system [PDF]

, 2023
Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important.
Fujii, Natsuko, Hirabayashi, Kenichi, Hori, Shuho, Iijima, Takatoshi, Ito, Masatoshi, Jessen, Henning J, Kakimoto, Yu, Kikuchi, Kenta, Kohara, Saori, Kurotaki, Daisuke, Nagata, Eiichiro, Saiardi, Adolfo, Tanaka, Masayuki, Wittwer, Christopher   +13 more
core  

Characterization of PPIP5Ks using pharmacological and chemical biology approaches

This thesis describes the development of a chemical tool directed against the kinase domain of PPIP5K. Furthermore, the functions of the phosphatase domain were biochemically characterized, complementing structural investigations. A high-throughput screening was carried out to identify lead structures for PPIP5K2 kinase inhibitors, yielding a single ...
openaire   +1 more source

Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules [PDF]

, 2017
Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in addition to monophosphates.
A Burton, A Burton, A Chakraborty, A Chakraborty, A Chakraborty, A Feoktistova, A Lonetti, A Nagel, A Prasad, A Saiardi, A Saiardi, A Saiardi, A Saiardi, A Saiardi, A Saiardi, A Saiardi, A Saiardi, AM Marmelstein, AM Riley, AS Carroll, BH Morrison, BH Morrison, BH Morrison, BH Morrison, BH Morrison, C Auesukaree, C Azevedo, C Azevedo, C Azevedo, C Fu, C Gu, C Illies, C Ye, CJ Barker, CJ Barker, CJ Barker, CP Downes, D Laha, DM Landis, E Bucking-Throm, E Dubois, E Nagata, E Nagata, E Nagata, EA Steidle, F Pisani, F Rao, F Rao, F Rao, FS Menniti, GW Mayr, GW Mayr, H Banfic, H Lin, H Wang, H Wang, H Wang, HR Luo, HR Luo, HR Luo, I Corthesy-Theulaz, I Pavlovic, J Kaur, J Li, J Worley, JH Choi, JH Conway, K Choi, K Choi, K Gardner, KN Huang, L Stephens, LM Yates, M Bennett, M Chanduri, M Desai, M Hothorn, M Rosner, M Wu, M Wu, MA Koldobskiy, MA Koldobskiy, MC Glennon, ME Lenburg, MM Tsui, MP Thomas, MS Wilson, MS Wilson, NA Gokhale, NA Gokhale, NK Pulloor, O Losito, P Draskovic, PC Fridy, Q Zhu, R Bhandari, R Bhandari, R Taylor Jr, R Wild, RF Irvine, RH Michell, RS Jadav, RS Jadav, RS Kilari, S Capolicchio, S Ghosh, S Mulugu, SB Shears, SB Shears, SB Shears, SB Shears, SB Shears, SC Li, SG Thota, SG Thota, SJ York, SM Onnebo, ST Safrany, ST Yong, T Laussmann, T Wundenberg, T Wundenberg, T-S Lee, W Yu, X Pesesse, Y Matsuoka, Y Xu, YS Lee, YS Lee, Z Szijgyarto, Z Zhang   +130 more
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Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain. [PDF]

, 2018
Proteins containing a SPX domain are involved in phosphate (Pi) homeostasis, including Pi transport and adaptation to Pi deficiency. The SPX domain harbors a basic surface binding Pi at low affinity and inositol pyrophosphates (PP-InsPs) at high affinity.
Hothorn, M., Jung, J.Y., Poirier, Y., Ried, M.K.   +3 more
core   +1 more source

Harnessing {13}^C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR [PDF]

, 2019
Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are an important group of metabolites and mediate a wide range of processes in eukaryotic cells. To elucidate the functions of these molecules, robust techniques for the characterization of inositol ...
Fiedler, D, Harmel, RK, Nguyen Trung, M, Puschmann, R, Saiardi, A, Schmieder, P   +5 more
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Identification of a functional nuclear translocation sequence in hPPIP5K2 [PDF]

, 2015

core   +1 more source

Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe [PDF]

, 2018
The generation of two daughter cells with the same genetic information requires error-free chromosome segregation during mitosis. Chromosome transmission fidelity is dependent on spindle structure/function, which requires Asp1 in the fission yeast ...
Fleig, U, Jakopec, V, Kuenzel, NA, Pascual-Ortiz, M, Saiardi, A, Span, I, Vangala, A, Walla, E   +7 more
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Characterization of Inorganic Polyphosphate in Mammalian Cells [PDF]

, 2020
Inorganic polyphosphate (polyP) is a linear chain of three to around one thousand orthophosphates linked by phosphoanhydride bonds. Not only is polyP considered as a “molecular fossil” that existed on the primordial earth, but it is also universally ...
Xie, Lihan
core  

Role of transporters in regulating mammalian intracellular inorganic phosphate. [PDF]

Front Pharmacol, 2023
Jennings ML.
europepmc   +1 more source

Development of a yeast model to study the contribution of vacuolar polyphosphate metabolism to lysine polyphosphorylation [PDF]

, 2019
A recently discovered protein post-translational modification, lysine polyphosphorylation (K-PPn), consists of the covalent attachment of inorganic polyphosphate (polyP) to lysine residues.
Azevedo, C, Desfougères, Y, Jessen, HJ, Jiramongkol, Y, Partington, H, Saiardi, A, Singh, J, Steck, N, Trakansuebkul, S   +8 more
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