Results 31 to 40 of about 261 (97)

KO of 5-InsP₇ kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype. [PDF]

Proc Natl Acad Sci U S A, 2017
Significance Therapeutic improvements to human health can accrue from understanding the bidirectional relationship between cell signaling and bioenergetic homeostasis.
Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB.   +7 more
europepmc   +2 more sources

VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis [PDF]

, 2015
Diphosphorylated inositol polyphosphates, also referred to as inositol pyrophosphates, are important signaling molecules that regulate critical cellular activities in many eukaryotic organisms, such as membrane trafficking, telomere maintenance, ribosome
Zheng, Ning, Schaaf, Gabriel, Dynowski, Marek, Campos, Marília K. F. de, Weiß, Michael, van Wees, Saskia C. M., Sub Plant-Microbe Interactions, Iven, Tim, de Campos, Marília K F, Capolicchio, Samanta, Saiardi, Adolfo, Wees, Saskia C. M. van, Jessen, Henning J., Laha, Debabrata, Jessen, Henning J, Jessen, Henning, Plant Microbe Interactions, Mao, Haibin, Feussner, Ivo, Freyer, Marc, Azevedo, Cristina, Steenbergen, Merel, de Campos, Marilia K. F., Gaugler, Philipp, Johnen, Philipp, van Wees, Saskia C M, Laha D, de Campos MK, Weiß M, Mao H, Feussner I, Zheng N, Azevedo C, Gaugler P, Dynowski M, Johnen P, Van Wees SC, Iven T, Freyer M, Schaaf G, Jessen HJ, Capolicchio S, Saiardi A, Steenbergen M   +43 more
core   +1 more source

Steps of the PPIP5K HTS Assay.

, 2016
Steps of the PPIP5K HTS Assay.
Huanchen Wang (1500046), Michael A. Stashko (1870828), Kenneth H. Pearce (2417548), Stephen V. Frye (425632), Yi An (300508), Stephen B. Shears (528105), Henning J. Jessen (1500052), Brandi M. Baughman (145837), Dmitri Kireev (146259)   +8 more
core   +1 more source

Analysis of the mechanism of inhibition of PPIP5K by UNC10112646 and UNC10225498.

, 2016
Assays were performed in HTS format with 2-fold serial dilutions from 100 μM of either UNC10112646 (squares) and UNC10225498 (circles) and varying concentrations of ATP as indicated. Data represent means and standard errors from 3 experiments.
Huanchen Wang (1500046), Michael A. Stashko (1870828), Kenneth H. Pearce (2417548), Stephen V. Frye (425632), Yi An (300508), Stephen B. Shears (528105), Henning J. Jessen (1500052), Brandi M. Baughman (145837), Dmitri Kireev (146259)   +8 more
core   +1 more source

The enzymes of human diphosphoinositol polyphosphate metabolism

The FEBS Journal, Volume 281, Issue 1, Page 14-33, January 2014., 2014
This review covers the three classes of enzymes involved in the metabolism of diphosphoinositol polyphosphates – inositol hexakisphosphate kinases (IP6K), inositol hexakisphosphate and diphosphoinositol‐pentakisphosphate kinases (PPIP5K), and diphosphoinositol polyphosphate phosphohydrolases (DIPP).
Mark P. Thomas, Barry V. L. Potter
wiley   +1 more source

Inositol phosphate pathway evolution and synthesis in Dictyostelium discoideum [PDF]

, 2020
Inositol phosphates (InsPs) are polar water-soluble derivatives of the six- carbon cyclitol inositol. They are synthesized, through phosphorylation reactions, by kinases of four distinct families: IPK, IP5-2K, ITPK1 and PPIP5K, which are thought to be ...
Portela Torres, Paloma
core   +1 more source

HPLC analysis of the effects of UNC10225498 and UNC10112646 upon the kinase activities of PPIP5K and IP6K.

, 2016
Kinase reactions contained either vehicle (0.5% DMSO) or inhibitor in 0.5% DMSO. Reactions were quenched and analyzed by HPLC as described in the methods section.
Huanchen Wang (1500046), Michael A. Stashko (1870828), Kenneth H. Pearce (2417548), Stephen V. Frye (425632), Yi An (300508), Stephen B. Shears (528105), Henning J. Jessen (1500052), Brandi M. Baughman (145837), Dmitri Kireev (146259)   +8 more
core   +1 more source

VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP₈ and Jasmonate-Dependent Defenses in Arabidopsis [PDF]

, 2015
Diphosphorylated inositol polyphosphates, also referred to as inositol pyrophosphates, are important signaling molecules that regulate critical cellular activities in many eukaryotic organisms, such as membrane trafficking, telomere maintenance, ribosome
Johnen, P, De Campos, MKF, Zheng, N, Freyer, M, Feussner, I, Laha, D, Gaugler, P, Iven, T, Azevedo, C, Weiss, M, Steenbergen, M, Jessen, HJ, Saiardi, A, Mao, H, Capolicchio, S, Van Wees, SCM, Schaaf, G, Dynowski, M   +17 more
core   +1 more source

Inositol phosphate kinases in the eukaryote landscape [PDF]

, 2020
Inositol phosphate encompasses a large multifaceted family of signalling molecules that originate from the combinatorial attachment of phosphate groups to the inositol ring. To date, four distinct inositol kinases have been identified, namely, IPK, ITPK,
Desfougères, Y, Saiardi, A, Laha, D, Portela-Torres, P   +3 more
core   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, Volume 6, Issue 5, October 2025.
The recent advancements in the application of CRISPR/Cas9‐edited tumor‐associated immune cells in cancer therapy are summarized, including T lymphoid cells, natural killer cells, macrophages, and B lymphoid cells et al., exhibiting a potential impact on the pathological status of cancer. This review also addresses the current challenges associated with
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source