Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease [PDF]
, 2016 Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders ...
Bruni, AC +6 more
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The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis [PDF]
, 2021 Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP6 also known as Phytic acid) present in the amoeba allowed the discovery of the more ...
Borghi, F +8 more
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Identification and characterization of evolutionarily conserved inositol pyrophosphate phosphohydrolases in plants [PDF]
, 2023 Inositol phosphates (InsPs), phosphate esters of myo-inositol, are cellular regulators with critical roles in a wide range of cellular processes in eukaryotes.
Gaugler, Philipp
core +1 more source
The Asp1 pyrophosphatase from S. pombe hosts a [2Fe-2S]2+ cluster in vivo [PDF]
, 2021 The Schizosaccharomyces pombe Asp1 protein is a bifunctional kinase/pyrophosphatase that belongs to the highly conserved eukaryotic diphosphoinositol pentakisphosphate kinase PPIP5K/Vip1 family.
Birrell, James A +7 more
core +1 more source
INOSITOL (1,3,4) TRIPHOSPHATE 5/6 KINASE1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis [PDF]
, 2022 The combinatorial phosphorylation of myo-inositol results in the generation of different inositol phosphates (InsPs), of which phytic acid (InsP6) is the most abundant species in eukaryotes.
Bhattacharjee, Saikat +18 more
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Genetic analysis of cell cycle and chromatin regulation in quiescent fission yeast cells [PDF]
, 2022 During proliferation, cells produce their genetic materials to increase the number of cells, while in the absence of nutrients or by the induction of stimulus, the proliferative phase is stopped and entry into quiescence is triggered to increase their ...
Zahedi, Yasaman
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Cellular Functions of myo-Inositol-Derived Signaling Molecules in Yeast and Plants during Abiotic and Biotic Stresses [PDF]
, 2021 Myo-Inositol (Ins)-derived molecules are involved in many cellular processes. Besides the role as compatible solute, Ins represents the building block for a variety of molecules, which function as signaling molecules. Cells utilize insoluble (lipid-bound)
Johnen, Philipp
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The enzymes of human diphosphoinositol polyphosphate metabolism
The FEBS Journal, Volume 281, Issue 1, Page 14-33, January 2014., 2014 This review covers the three classes of enzymes involved in the metabolism of diphosphoinositol polyphosphates – inositol hexakisphosphate kinases (IP6K), inositol hexakisphosphate and diphosphoinositol‐pentakisphosphate kinases (PPIP5K), and diphosphoinositol polyphosphate phosphohydrolases (DIPP).
Mark P. Thomas, Barry V. L. Potter
wiley +1 more source
Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network [PDF]
, 2022 The water-soluble inositol phosphates (InsPs) represent a functionally diverse group of small-molecule messengers involved in a myriad of cellular processes.
Fandi, Zeinab +9 more
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Inositol phosphate kinases in the eukaryote landscape [PDF]
, 2020 Inositol phosphate encompasses a large multifaceted family of signalling molecules that originate from the combinatorial attachment of phosphate groups to the inositol ring. To date, four distinct inositol kinases have been identified, namely, IPK, ITPK,
Desfougères, Y +3 more
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