Results 11 to 20 of about 261 (97)

Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development. [PDF]

PLoS Genetics
Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Florian Laurent, Simon M Bartsch, Anuj Shukla, Felix Rico-Resendiz, Daniel Couto, Christelle Fuchs, Joël Nicolet, Sylvain Loubéry, Henning J Jessen, Dorothea Fiedler, Michael Hothorn   +10 more
doaj   +4 more sources

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. [PDF]

PLoS ONE, 2016
Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches.
Brandi M Baughman, Huanchen Wang, Yi An, Dmitri Kireev, Michael A Stashko, Henning J Jessen, Kenneth H Pearce, Stephen V Frye, Stephen B Shears   +8 more
doaj   +4 more sources

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates - detection, function, and regulation. [PDF]

FEBS Lett
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Lampe S, Mohanty TK, Bhandari R, Fiedler D.   +3 more
europepmc   +2 more sources

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis

BMC Biology, 2021
Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla, Mandeep Kaur, Swati Kanwar, Gazaldeep Kaur, Shivani Sharma, Shubhra Ganguli, Vandana Kumari, Koushik Mazumder, Pratima Pandey, Hatem Rouached, Vikas Rishi, Rashna Bhandari, Ajay Kumar Pandey   +12 more
doaj   +3 more sources

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals

Molecules, 2020
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Min Gyu Kim, Seulgi Lee, Seyun Kim
exaly   +3 more sources

Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks

Animal Cells and Systems, 2018
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seyun Kim
exaly   +2 more sources

NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis. [PDF]

J Integr Plant Biol
NUDIX‐type hydrolase enzymes of subclade I and II preferentially target the inositol pyrophosphate messengers 4‐ and 3‐InsP7, respectively. Inactivation of subclade II NUDTs disrupts phosphate homeostasis and enhances bacterial resistance, revealing connections between defense and nutrient signaling.
Schneider R, Lami K, Prucker I, Stolze SC, Strauß A, Schmidt JM, Bartsch SM, Langenbach K, Lange E, Ritter K, Furkert D, Faiß N, Kumar S, Shamim Hasan M, Makris A, Krusenbaum L, Wege S, Belay YZ, Kriescher S, The J, Harings M, Grundler FMW, Ried-Lasi MK, Schoof H, Gaugler P, Kamleitner M, Fiedler D, Nakagami H, Giehl RFH, Lahaye T, Bhattacharjee S, Jessen HJ, Gaugler V, Schaaf G.   +33 more
europepmc   +2 more sources

Characterization of PPIP5Ks using pharmacological and chemical biology approaches [PDF]

This thesis describes the development of a chemical tool directed against the kinase domain of PPIP5K. Furthermore, the functions of the phosphatase domain were biochemically characterized, complementing structural investigations. A high-throughput screening was carried out to identify lead structures for PPIP5K2 kinase inhibitors, yielding a single ...
Bartsch, Simon Maria
openaire   +2 more sources

Inositol pyrophosphate kinases in health and disease [PDF]

FEBS Letters
Chenglai Fu
exaly   +2 more sources