Results 11 to 20 of about 200 (78)

Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks

Animal Cells and Systems, 2018
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seung Eun Park, Seyun Kim   +3 more
doaj   +2 more sources

Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. [PDF]

Chemistry, 2023
How do pyrophosphate analogs compare? The synthesis of a fluorinated analog of an inositol pyrophosphate messenger is reported. Comparison of the physicochemical and biochemical properties of a range of closely related analogs showcases that subtle modifications can distinctly influence the behavior of molecules.
Hostachy S, Wang H, Zong G, Franke K, Riley AM, Schmieder P, Potter BVL, Shears SB, Fiedler D.   +8 more
europepmc   +2 more sources

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis.

Adv Biol Regul, 2022
Desfougères Y, Portela-Torres P, Qiu D, Livermore TM, Harmel RK, Borghi F, Jessen HJ, Fiedler D, Saiardi A.   +8 more
europepmc   +2 more sources

NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis. [PDF]

J Integr Plant Biol
NUDIX‐type hydrolase enzymes of subclade I and II preferentially target the inositol pyrophosphate messengers 4‐ and 3‐InsP7, respectively. Inactivation of subclade II NUDTs disrupts phosphate homeostasis and enhances bacterial resistance, revealing connections between defense and nutrient signaling.
Schneider R, Lami K, Prucker I, Stolze SC, Strauß A, Schmidt JM, Bartsch SM, Langenbach K, Lange E, Ritter K, Furkert D, Faiß N, Kumar S, Shamim Hasan M, Makris A, Krusenbaum L, Wege S, Belay YZ, Kriescher S, The J, Harings M, Grundler FMW, Ried-Lasi MK, Schoof H, Gaugler P, Kamleitner M, Fiedler D, Nakagami H, Giehl RFH, Lahaye T, Bhattacharjee S, Jessen HJ, Gaugler V, Schaaf G.   +33 more
europepmc   +2 more sources

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +1 more source

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis [PDF]

Journal of Biological Chemistry, 2017
Proteins responsible for Pi homeostasis are critical for all life. In Saccharomyces cerevisiae, extracellular [Pi] is “sensed” by the inositol-hexakisphosphate kinase (IP6K) that synthesizes the intracellular inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP7) as follows: during a period of Pi starvation, there is a decline
Gu, Chunfang, Nguyen, Hoai-Nghia, Hofer, Alexandre, Jessen, Henning, Dai, Xuming, Wang, Huanchen, Shears, Stephen B.   +6 more
openaire   +5 more sources

Potential therapies targeting nuclear metabolic regulation in cancer

MedComm, Volume 4, Issue 6, December 2023., 2023
1. Cell metabolism and gene control are significantly integrated and regulated by one another. 2. There is a positive feedback loop of metabolism‐epigenetics‐gene regulation which control cancer progression. 3. The discovery of metabolic enzymes and their functions in the nucleus will provide more insights into cancer therapy.
Yanjie Chen, Jie Xu, Xiaoyi Liu, Linlin Guo, Ping Yi, Chunming Cheng   +5 more
wiley   +1 more source

Inositol polyphosphates and target of rapamycin kinase signalling govern photosystem II protein phosphorylation and photosynthetic function under light stress in Chlamydomonas

New Phytologist, Volume 232, Issue 5, Page 2011-2025, December 2021., 2021
Summary Stress and nutrient availability influence cell proliferation through complex intracellular signalling networks. In a previous study it was found that pyro‐inositol polyphosphates (InsP7 and InsP8) produced by VIP1 kinase, and target of rapamycin (TOR) kinase signalling interacted synergistically to control cell growth and lipid metabolism in ...
Inmaculada Couso, Amanda L. Smythers, Megan M. Ford, James G. Umen, José L. Crespo, Leslie M. Hicks   +5 more
wiley   +1 more source

Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Plants, 2020
Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed, Olusegun Adepoju, Glenda Gillaspy   +2 more
doaj   +1 more source

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis

BMC Biology, 2021
Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla, Mandeep Kaur, Swati Kanwar, Gazaldeep Kaur, Shivani Sharma, Shubhra Ganguli, Vandana Kumari, Koushik Mazumder, Pratima Pandey, Hatem Rouached, Vikas Rishi, Rashna Bhandari, Ajay Kumar Pandey   +12 more
doaj   +1 more source