Results 31 to 40 of about 5,995 (168)

Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP₅. [PDF]

Chem Sci, 2023
Inositol pyrophosphates are important biomolecules associated with apoptosis, cell growth and kinase regulation, yet their exact biological roles are still emerging and probes do not exist for their selective detection.
Shipton ML, Jamion FA, Wheeler S, Riley AM, Plasser F, Potter BVL, Butler SJ.   +6 more
europepmc   +2 more sources

Inositol Pyrophosphate Pyrotechnics [PDF]

Cell Metabolism, 2007
Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest. In the April 6, 2007 issue of Science, two papers (Lee et al., 2007; Mulugu et al., 2007) demonstrate the occurrence of a novel inositol pyrophosphate molecule in yeast and elucidate its role in ...
Bhandari, Rashna, Chakraborty, Anutosh, Snyder, Solomon H.   +2 more
openaire   +2 more sources

Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism. [PDF]

Biochem J
Inositol phosphate (InsP) and diphosphoinositol phosphate (PP-InsP) analysis in tissues is plagued by multiple difficulties of sensitivity, regioisomer resolution and the need for radiolabeling with metabolic precursors.
Sprigg C, Whitfield HL, Leftwich PT, Kuo HF, Chiou TJ, Saiardi A, Shipton ML, Riley AM, Potter BVL, Scholey D, Burton E, Bedford MR, Brearley CA.   +12 more
europepmc   +2 more sources

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

Nature Communications, 2021
Plants regulate phosphate homeostasis via the interaction of PHR transcription factors with SPX receptors bound to inositol pyrophosphate signaling molecules.
Martina K. Ried, Rebekka Wild, Jinsheng Zhu, Joka Pipercevic, Kristina Sturm, Larissa Broger, Robert K. Harmel, Luciano A. Abriata, Ludwig A. Hothorn, Dorothea Fiedler, Sebastian Hiller, Michael Hothorn   +11 more
doaj   +1 more source

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +1 more source

Preparation of Quality Inositol Pyrophosphates [PDF]

Journal of Visualized Experiments, 2011
Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP(5;)) and inositol hexakisphosphate (phytic acid or IP(6;)).
Loss, Omar, Azevedo, Cristina, Szijgyarto, Zsolt, Bosch, Daniel, Saiardi, Adolfo   +4 more
openaire   +2 more sources

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP₇ metabolism in the enteric nervous system. [PDF]

J Biol Chem, 2023
Inositol pyrophosphates (PP-IPs) regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important.
Ito M, Fujii N, Kohara S, Hori S, Tanaka M, Wittwer C, Kikuchi K, Iijima T, Kakimoto Y, Hirabayashi K, Kurotaki D, Jessen HJ, Saiardi A, Nagata E.   +13 more
europepmc   +2 more sources

Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-InsP7. [PDF]

Biosci Rep
Inositol pyrophosphates (PP-InsPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-InsPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser.
Hamid A, Ladke JS, Shah A, Ganguli S, Pal M, Singh A, Bhandari R.   +6 more
europepmc   +2 more sources

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in <i>S. pombe</i>. [PDF]

J Fungi (Basel), 2022
Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Kuenzel NA, Alcázar-Román AR, Saiardi A, Bartsch SM, Daunaraviciute S, Fiedler D, Fleig U.   +6 more
europepmc   +2 more sources

Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin. [PDF]

Cardiovasc Res
Aims Adiponectin is an adipocyte-derived circulating protein that exerts cardiovascular and metabolic protection. Due to the futile degradation of endogenous adiponectin and the challenges of exogenous administration, regulatory mechanisms of adiponectin
Fu L, Du J, Furkert D, Shipton ML, Liu X, Aguirre T, Chin AC, Riley AM, Potter BVL, Fiedler D, Zhang X, Zhu Y, Fu C.   +12 more
europepmc   +2 more sources