Results 51 to 60 of about 5,995 (168)

Affinity enrichment and identification of inositol poly- and pyrophosphate interactomes

STAR Protocols, 2021
Summary: This protocol describes an affinity enrichment approach from mammalian cell extracts to identify protein binding partners of inositol hexakisphosphate (InsP6) and 5-diphosphoinositol pentakisphosphate (5PP-InsP5), two important eukaryotic ...
David Furkert, Michal Nadler-Holly, Dorothea Fiedler   +2 more
doaj   +1 more source

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.

PLoS Pathogens, 2014
The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-
Niyas Kudukkil Pulloor, Sajith Nair, Kathleen McCaffrey, Aleksandar D Kostic, Pradeep Bist, Jeremy D Weaver, Andrew M Riley, Richa Tyagi, Pradeep D Uchil, John D York, Solomon H Snyder, Adolfo García-Sastre, Barry V L Potter, Rongtuan Lin, Stephen B Shears, Ramnik J Xavier, Manoj N Krishnan   +16 more
doaj   +1 more source

Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Plants, 2020
Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed, Olusegun Adepoju, Glenda Gillaspy   +2 more
doaj   +1 more source

The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling

Biomolecules, 2023
Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed.
Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty   +7 more
doaj   +1 more source

Inositol Pyrophosphates as Mammalian Cell Signals [PDF]

Science Signaling, 2011
Identification and knockout of their biosynthetic enzymes has shed light on the diverse functions of the inositol pyrophosphates.
Chakraborty, A Chakraborty, Anutosh, Kim, S Kim, Seyun, Snyder, SH Snyder, Solomon H.   +2 more
openaire   +2 more sources

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis.

Adv Biol Regul, 2022
Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP6 also known as Phytic acid) present in the amoeba allowed the discovery of the more ...
Desfougères Y, Portela-Torres P, Qiu D, Livermore TM, Harmel RK, Borghi F, Jessen HJ, Fiedler D, Saiardi A.   +8 more
europepmc   +2 more sources

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular Metabolism, 2016
Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty   +10 more
doaj   +1 more source

The inositol pyrophosphate 5-InsP₇ regulates mitochondrial polyphosphate synthesis and bioenergetic function. [PDF]

J Biol Chem
Inorganic polyphosphate (polyP) is a linear polymer of phosphate residues linked by phosphoanhydride bonds. PolyP remains poorly understood in mammals due to its low abundance and lack of information on its metabolism.
Ladke JS, Khan A, Singh A, Jessen HJ, Kolthur-Seetharam U, Jaiswal M, Bhandari R.   +6 more
europepmc   +2 more sources

An inositol pyrophosphate interaction screen provides insight into the regulation of plant casein kinase II

bioRxiv
Sturm K, Pri-Tal O, Rico-Resendiz F, Verma Y, Richter A, Chen H, Broger L, Hothorn LA, Fiedler D, Panse VG, Hothorn M.   +10 more
europepmc   +2 more sources

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate [PDF]

Proceedings of the National Academy of Sciences, 2001
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK).
A, Saiardi, E, Nagata, H R, Luo, A, Sawa, X, Luo, A M, Snowman, S H, Snyder   +6 more
openaire   +2 more sources