Results 51 to 60 of about 13,047 (201)

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular Metabolism, 2016
Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty   +10 more
doaj   +1 more source

Phosphorus distribution in soils from Australian dairy and beef rearing pastoral systems [PDF]

, 2016
The influence of soil type and management practices on P distribution in soils from Australian dairy and beef rearing pastoral systems has been investigated by chemical measurements and phosphorus-31 (31P) nuclear magnetic resonance (NMR) spectroscopy ...
Adeloju, Samuel B., Smernik, Ronald, Webb, Benjamin, Webb, Benjamin   +3 more
core   +3 more sources

Inositol pyrophosphates modulate hydrogen peroxide signalling

Biochemical Journal, 2009
Inositol pyrophosphates are involved in a variety of cellular functions, but the specific pathways and/or downstream targets remain poorly characterized. In the present study we use Saccharomyces cerevisiae mutants to examine the potential roles of inositol pyrophosphates in responding to cell damage caused by ROS (reactive oxygen species).
Onnebo, Sara Maria Nancy, Saiardi, Adolfo   +1 more
openaire   +3 more sources

Acclimation responses of Arabidopsis thaliana to sustained phosphite treatments [PDF]

, 2013
Phosphite () induces a range of physiological and developmental responses in plants by disturbing the homeostasis of the macronutrient phosphate. Because of its close structural resemblance to phosphate, phosphite impairs the sensing, membrane transport,
Berkowitz, O., Fenske, R., Finnegan, P.M., Hardy, G.E.S.J., Jost, R., Kollehn, D.O., Lambers, H., O'Brien, P.A.   +7 more
core   +2 more sources

Inositol pyrophosphates: Why so many phosphates? [PDF]

Advances in Biological Regulation, 2015
The inositol pyrophosphates (PP-InsPs) are a specialized group of "energetic" signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and diphosphates are crammed around the six-carbon, inositol ring.
openaire   +2 more sources

Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis [PDF]

, 2018
Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to ...
Alcazar-Roman, Alexova, Auesukaree, Aung, Azevedo, Azevedo, Bari, Berridge, Boer, Bosch, Brearley, Brearley, Brearley, Brearley, Chamberlain, Chiou, Chiou, Cho, Choi, Clough, Curtis, Desai, Duff, Franco-Zorrilla, Gonzalez, Hammond, Hanke, Ho, Holford, Huang, Huang, Irvine, Kanehara, Karimi, Kim, Kuo, Kusano, Laha, Lee, Lee, Lee, Lemtiri-Chlieh, Lemtiri-Chlieh, Lin, Lin, Lin, Liu, Liu, Liu, Lonetti, Martin, Mosblech, Mulugu, Munnik, Munnik, Munnik, Murphy, Müller, Nagy, Norbis, Pant, Perera, Perera, Perera, Phillippy, Pradet, Puga, Raboy, Raboy, Rao, Rouached, Saiardi, Saiardi, Saiardi, Schell, Schneider, Secco, Secco, Shears, Stenzel, Stephens, Stephens, Stevenson-Paulik, Stevenson-Paulik, Sweetman, Szijgyarto, Torabinejad, Vajanaphanich, Voglmaier, Wang, Whiteford, Wild, Williams, Wilson, Wreggett, Wu, Wu, Wundenberg, Xiong, Xu, Xu, Yang, Yang, York, Zonia   +104 more
core   +2 more sources

Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Epigenetic modifications of chromatin are emerging as important regulatory mechanisms of many nuclear processes. Numerous proteins have been identified that mediate these modifications in a dynamic manner.
Adam, Burton, Cristina, Azevedo, Catia, Andreassi, Antonella, Riccio, Adolfo, Saiardi   +4 more
openaire   +2 more sources

The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]

PLoS Genetics, 2014
Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann, Carmen Risse, Constanze Seidel, Thomas Pohlmann, Visnja Jakopec, Eva Walla, Pascal Ramrath, Norio Takeshita, Sebastian Baumann, Michael Feldbrügge, Reinhard Fischer, Ursula Fleig   +11 more
doaj   +1 more source

Cellular IP₆ Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP₆ Are Attenuated for Infection and Replication [PDF]

, 2019
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Böcking, Till, Faysal, K. M.Rifat, Fletcher, Adam J., Freed, Eric O., James, Leo C., Kleinpeter, Alex, Mallery, Donna L., Novikova, Mariia, Saiardi, Adolfo, Vaysburd, Marina, Wilson, Miranda S.C.   +10 more
core   +3 more sources

Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism. [PDF]

Fungal Genet Biol, 2018
Cryptococcus neoformans is the most common cause of deadly fungal meningitis. This fungus has a complex inositol acquisition and utilization system, and our previous studies have shown the importance of inositol utilization in cryptococcal development and virulence. However, how inositol utilization is regulated in this fungus remains unknown.
Liao G, Wang Y, Liu TB, Kohli G, Qian W, Shor E, Subbian S, Xue C.   +7 more
europepmc   +4 more sources