Results 71 to 80 of about 58,667 (143)

Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules [PDF]

, 2017
Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in addition to monophosphates.
Sen, Jayraj, Shah, Akruti, Shubhra Ganguli, Rashna Bhandari, Akruti Shah, Jayraj Sen, Ganguli, Shubhra, Bhandari, Rashna   +7 more
core   +2 more sources

Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione‐resistant Amaranthus tuberculatus biotype

Pest Management Science, Volume 82, Issue 7, Page 6387-6398, July 2026.
Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest, Marianne Bessette, Geneviève Gagnon, Sandra Flores‐Mejia, Brahim Soufiane, Marie‐Claire Goulet, Dominique Michaud   +6 more
wiley   +1 more source

[PSI+] prion propagation is controlled by inositol polyphosphates

, 2017
Significance The [PSI+] prion of baker’s yeast is a filamentous polymer (amyloid) of the Sup35 protein, producing readthrough of translation termination and different degrees of growth slowing, depending on the prion variant.
Herman K. Edskes, Amy C. Kelly, Reed B. Wickner, Evgeny E. Bezsonov   +3 more
core   +1 more source

Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase

mBio
Inositol pyrophosphate 1,5-IP8 regulates expression of a fission yeast phosphate homeostasis regulon, comprising phosphate acquisition genes pho1, pho84, and tgp1, via its action as an agonist of precocious termination of transcription of the upstream ...
Shreya Ghosh, Ana M. Sanchez, Beate Schwer, Isabel Prucker, Nikolaus Jork, Henning J. Jessen, Stewart Shuman   +6 more
doaj   +1 more source

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery

Journal of Fungi, 2016
Opportunistic fungi are a major cause of morbidity and mortality world-wide, particularly in immunocompromised individuals. Developing new treatments to combat invasive fungal disease is challenging given that fungal and mammalian host cells are ...
Cecilia Li, Sophie Lev, Adolfo Saiardi, Desmarini Desmarini, Tania C. Sorrell, Julianne T. Djordjevic   +5 more
doaj   +1 more source

The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA

Nature Communications
The response of plants to phosphate starvation engages PHR (CC-MYB-PHOSPHATE STARVATION RESPONSE) transcription factors that bind to P1BS (GNATATNC) promoter elements of phosphate-starvation induced (PSI) genes. The encoded proteins include single-domain
Hayley L. Whitfield, Megan Gilmartin, Andrew M. Riley, Megan L. Shipton, Barry V. L. Potter, Andrew M. Hemmings, Charles A. Brearley   +6 more
doaj   +1 more source

VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis [PDF]

, 2015
Diphosphorylated inositol polyphosphates, also referred to as inositol pyrophosphates, are important signaling molecules that regulate critical cellular activities in many eukaryotic organisms, such as membrane trafficking, telomere maintenance, ribosome
Zheng, Ning, Schaaf, Gabriel, Dynowski, Marek, Campos, Marília K. F. de, Weiß, Michael, van Wees, Saskia C. M., Sub Plant-Microbe Interactions, Iven, Tim, de Campos, Marília K F, Capolicchio, Samanta, Saiardi, Adolfo, Wees, Saskia C. M. van, Jessen, Henning J., Laha, Debabrata, Jessen, Henning J, Jessen, Henning, Plant Microbe Interactions, Mao, Haibin, Feussner, Ivo, Freyer, Marc, Azevedo, Cristina, Steenbergen, Merel, de Campos, Marilia K. F., Gaugler, Philipp, Johnen, Philipp, van Wees, Saskia C M, Laha D, de Campos MK, Weiß M, Mao H, Feussner I, Zheng N, Azevedo C, Gaugler P, Dynowski M, Johnen P, Van Wees SC, Iven T, Freyer M, Schaaf G, Jessen HJ, Capolicchio S, Saiardi A, Steenbergen M   +43 more
core   +1 more source

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.

PLoS ONE, 2016
The HCT116 cell line, which has a pseudo-diploid karotype, is a popular model in the fields of cancer cell biology, intestinal immunity, and inflammation.
Chunfang Gu, Miranda S C Wilson, Henning J Jessen, Adolfo Saiardi, Stephen B Shears   +4 more
doaj   +1 more source

Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability

Molecular Brain
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin, Aili Liu, Alfred C. Chin, Chenglai Fu, Hui Shen, Weiwei Cheng   +5 more
doaj   +1 more source

The Use of Grating-Coupled Interferometry to Study Inositol Pyrophosphate–Protein Interactions

Grating-coupled interferometry (GCI) is a biophysical method suitable to studying the binding kinetics of protein-ligand interactions. Here, we describe the application of biotinylated inositol pyrophosphate (PP-InsP) nutrient messengers to characterize ...
Sturm, Kristina, Hothorn, Michael
core   +1 more source