Results 91 to 100 of about 5,995 (168)

Inositol pyrophosphates: Why so many phosphates? [PDF]

Advances in Biological Regulation, 2015
The inositol pyrophosphates (PP-InsPs) are a specialized group of "energetic" signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and diphosphates are crammed around the six-carbon, inositol ring.
openaire   +2 more sources

The break in the cycle: Inositol pyrophosphate fluxomics disentangled via mathematical modelling

bioRxiv
This study investigates the metabolic pathways of inositol pyrophosphates (IPPs) in the yeast cell line ΔSPX and the human tumor cell line HCT116. Utilizing pulse-labelling experiments with 18O water and ordinary differential equation (ODE) models, we ...
H. Jacques, Kim Geun-Don, Guizhen Liu, Maria Giovanna De Leo, Mayer Andreas, Jessen Henning, Timmer Jens   +6 more
semanticscholar   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Structural basis of phosphate export by human XPR1

Nature Communications
Phosphorus in crucial for all living organisms. In vertebrate, cellular phosphate homeostasis is partly controlled by XPR1, a poorly characterized inositol pyrophosphate-dependent phosphate exporter.
Qixian He, Ran Zhang, Sandrine Tury, Valérie Courgnaud, Fenglian Liu, Jean-luc Battini, Baobin Li, Qingfeng Chen   +7 more
doaj   +1 more source

Transcriptome assemblies for two drug‐type cannabis chemotypes by long‐read RNA sequencing

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Cannabis sativa has undergone over 10,000 years of domestication, resulting in extensive genetic and phenotypic diversity among cultivated chemotypes. Increased medical and recreational use of specialized metabolites accumulating in cannabis glandular trichomes—primarily the cannabinoids ∆9‐tetrahydrocannabinol (THC) and cannabidiol (CBD)—has ...
Oliver Berkowitz, Ricarda Jost, Sophia Ng, Antony Bacic, James Whelan, Mathew G. Lewsey   +5 more
wiley   +1 more source

Depth‐dependent mechanisms regulate accumulation of plant‐ and microbial‐derived residues under long‐term nitrogen addition in a semiarid grassland

Functional Ecology, Volume 40, Issue 6, Page 1790-1808, June 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Plant‐ and microbial‐derived residues constitute the primary sources of soil organic carbon (SOC) in grassland ecosystems. However, their differential responses to chronic nitrogen (N) enrichment and the depth‐dependent mechanisms governing their accumulation remain ...
Xiaobo Yuan, Shize Yao, Guiyao Zhou, Adam Frew, Peter Dietrich, Yuan Li, Ying Wang, Tian Ma, Ning Chen, Yaodan Zhang, Jingrun Xu, Shujuan Wu, Mengfei Zhang, Yaodong Li, Baoming Du, Peijing Chang, Tianhu Han, Decao Niu, Hua Fu, Zengru Wang   +19 more
wiley   +1 more source

Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes [PDF]

Advances in Enzyme Regulation, 2010
Inositol phosphates and inositol pyrophosphates are small molecule metabolites that play important roles in nuclear processes such as transcription control, mRNA export and DNA repair. On this wonderful occasion of the fiftieth anniversary of the Advances in Enzyme Regulation conference, it is a privilege to participate through presenting recent ...
Marco M, Tsui, John D, York
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Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen   +10 more
wiley   +1 more source

Inactivation Strategies of Clostridium perfringens in Foods: Current Challenges and Emerging Interventions

Food Frontiers, Volume 7, Issue 3, May 2026.
Clostridium perfringens forms heat‐resistant spores that complicate food safety. Physical methods (thermal processing, HPP, vacuum cooling, ozone treatments) and chemical interventions (natural antimicrobials, phosphates, nitrate/nitrite, organic acids) reduce vegetative cells and spores, though spore resistance remains a major challenge in food and ...
Deepak Subedi, Bharath Mallavarapu, Pranita Patil, Sujitha Bhumanapalli, Sandesh Chapagain, Kham Bahadur Khatri, Milan Kandel, Amit Kumar Singh   +7 more
wiley   +1 more source

Towards pharmacological intervention in inositol pyrophosphate signalling [PDF]

Biochemical Society Transactions, 2016
To help define the molecular basis of cellular signalling cascades, and their biological functions, there is considerable value in utilizing a high-quality chemical ‘probe’ that has a well-defined interaction with a specific cellular protein. Such reagents include inhibitors of protein kinases and small molecule kinases, as well as mimics or ...
openaire   +2 more sources