Results 81 to 90 of about 58,667 (143)

Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2

, 2011
The inositol pyrophosphate, diphosphoinositol pentakisphosphate, regulates p53 and protein kinase Akt signaling, and its aberrant increase in cells has been implicated in apoptosis and insulin resistance.
Adele M. Snowman, Michael A. Koldobskiy, Anutosh Chakraborty, Krishna R. Juluri, J. Kent Werner, Joseph Pietropaoli, Solomon H. Snyder, Asif K. Mustafa   +7 more
core   +1 more source

Enabling Technologies for the Dissection of Inositol Pyrophosphate Physiology

The diverse chemical structures of inositol pyrophosphates attract growing interest toward this class of small molecule messengers. However, their highly charged nature, the lack of a chromophore or a fluorophore, their close structural relatedness, and ...
Saiardi, Adolfo, Jessen, Henning J, Fiedler, Dorothea   +2 more
core   +1 more source

Unveiling the Plasmodium inositol (pyro)phosphate pathway: Highlighting inositol polyphosphate multikinase as a novel therapeutic target for malaria.

PLoS ONE
Plasmodium falciparum malaria is fatal if left untreated. Treatment is hampered by drug-resistant variants of the malaria parasite, highlighting the need to explore unique pathways for the development of new drugs with different mechanisms of action ...
Abigail Obuobi, Neils B Quashie, Nancy Odurowah Duah-Quashie, Jon R Sayers   +3 more
doaj   +1 more source

Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport

, 2016
Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are conserved eukaryotic signaling molecules that possess pyrophosphate and monophosphate moieties. Generated predominantly by Inositol Hexakisphosphate Kinases (IP6Ks), inositol
Chanduri, Manasa, Wu, Mingxuan, Malla, Aushaq Bashir, Fiedler, Dorothea, Rai, Ashim, Mallik, Roop, Bhandari, Rashna   +6 more
core   +1 more source

Pyrophosphate-Based Gemini Surfactants

, 2016
Two series of pyrophosphate-based gemini surfactants [diimidazolium (1) and disodium P,P‘-dialkyl pyrophosphate (2) (a, R = 1-octyl; b, R = 1-dodecyl; c, R = 2-dodecyl)] were synthesized, along with a series of imidazolium monoalkyl phosphate surfactants
David A. Jaeger (2668096), Yapin Wang (3029202), Richard L. Pennington (3055728)   +2 more
core   +1 more source

Elevation of inositol pyrophosphate IP₇ in the mammalian spinal cord of amyotrophic lateral sclerosis. [PDF]

Front Neurol, 2023
Ito M, Fujii N, Kohara S, Tanaka M, Takao M, Mihara B, Saito Y, Mizuma A, Nakayama T, Netsu S, Suzuki N, Kakita A, Nagata E.   +12 more
europepmc   +1 more source

Fungal inositol pyrophosphate IP7 is crucial for metabolic adaptation to the host environment and pathogenicity

, 2015
Inositol pyrophosphates (PP-IPs) comprising inositol, phosphate, and pyrophosphate (PP) are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never been addressed.
Saiardi, Adolfo, Schibeci, Stephen D., Li, Cecilia, Desmarini, Desmarini, Adolfo Saiardi, Fewings, Nicole L., Sorrell, Tania C., Nicole L. Fewings, Julianne T. Djordjevic, Raghwa Sharma, Lev, Sophie, Djordjevic, Julianne T., Sharma, Raghwa N. (R14531), Cecilia Li, Desmarini Desmarini, Sophie Lev, Tania C. Sorrell, Stephen D. Schibeci   +17 more
core   +1 more source

Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1

Nature Communications
Inorganic phosphate (Pi) has essential metabolic and structural roles in living organisms. The Pi exporter, XPR1/SLC53A1, is critical for cellular Pi homeostasis.
Qinyu Zhu, Madeleine F. Yaggi, Nikolaus Jork, Henning J. Jessen, Melinda M. Diver   +4 more
doaj   +1 more source

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

Nature Communications
Inositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenger 1,5-InsP8, the C-terminal phosphatase domain catalyzes PP-InsP breakdown ...
Pierre Raia, Kitaik Lee, Simon M. Bartsch, Felix Rico-Resendiz, Daniela Portugal-Calisto, Oscar Vadas, Vikram Govind Panse, Dorothea Fiedler, Michael Hothorn   +8 more
doaj   +1 more source

Crystal structure and enzymology of solanum tuberosum inositol tris/tetrakisphosphate kinase 1 (StITPK1) [PDF]

Inositol phosphates and their pyrophosphorylated derivatives are responsive to the phosphate supply and are agents of phosphate homeostasis and other aspects of physiology. It seems likely that the enzymes that interconvert these signals work against the
Shipton, Megan L., Potter, Barry V. L., Hemmings, Andrew M., Faba Rodriguez, Raquel, Whitfield, Hayley L., Brearley, Charles A., Riley, Andrew M., Li, Arthur W. H.   +7 more
core   +1 more source