<i>Lotus japonicus</i> VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza. [PDF]
Sci AdvPlant yield is often maximized by the extensive use of mineral fertilizers, which, however, has severe environmental consequences. Phosphate is particularly problematic as it represents a globally limited resource, and its runoff and soil erosion ...
Raj K +15 more
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bioRxivInositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular concentration must be tightly regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Laurent F +10 more
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Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism. [PDF]
Fungal Genet Biol, 2018 Cryptococcus neoformans is the most common cause of deadly fungal meningitis. This fungus has a complex inositol acquisition and utilization system, and our previous studies have shown the importance of inositol utilization in cryptococcal development and virulence. However, how inositol utilization is regulated in this fungus remains unknown.
Liao G +7 more
europepmc +4 more sources
How interdiction of inositol pyrophosphate catabolism perturbs the fission yeast response to phosphate starvation. [PDF]
Nucleic Acids ResIn fission yeast, inositol-1-pyrophosphates drive the synthesis of vacuolar inorganic polyphosphate (polyP), which serves as a phosphate reservoir during nutrient scarcity.
Babor J +5 more
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bioRxiv, 2023 Inositol pyrophosphates (PP-IPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-IPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser.
Aisha Hamid +6 more
semanticscholar +1 more source
The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]
PLoS Genetics, 2014 Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann +11 more
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Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis.
PLoS ONE, 2009 BackgroundInositol pyrophosphates are a recently characterized cell signalling molecules responsible for the pyrophosphorylation of protein substrates. Though likely involved in a wide range of cellular functions, the study of inositol pyrophosphates has
Oriana Losito +3 more
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Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers
bioRxiv, 2022 Inositol pyrophosphates are signaling molecules containing at least one phosphoanhydride bond that regulate a wide range of cellular processes in eukaryotes.
Philipp Gaugler +17 more
semanticscholar +1 more source
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine [PDF]
Open Biology, 2015 Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized.
Miranda S. C. Wilson +4 more
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Frontiers in Cell and Developmental Biology, 2023 Phosphate and calcium ions are nutrients that play key roles in growth, differentiation and the production of bioactive secondary metabolites in filamentous fungi. Phosphate concentration regulates the biosynthesis of hundreds of fungal metabolites.
Juan F. Martín
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