Results 61 to 70 of about 13,047 (201)
Towards pharmacological intervention in inositol pyrophosphate signalling. [PDF]
Biochem Soc Trans, 2016 To help define the molecular basis of cellular signalling cascades, and their biological functions, there is considerable value in utilizing a high-quality chemical ‘probe’ that has a well-defined interaction with a specific cellular protein. Such reagents include inhibitors of protein kinases and small molecule kinases, as well as mimics or ...
Shears SB.
europepmc +4 more sources
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis.
PLoS ONE, 2009 BackgroundInositol pyrophosphates are a recently characterized cell signalling molecules responsible for the pyrophosphorylation of protein substrates. Though likely involved in a wide range of cellular functions, the study of inositol pyrophosphates has
Oriana Losito +3 more
doaj +1 more source
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine [PDF]
Open Biology, 2015 Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized.
Miranda S. C. Wilson +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Phosphate and calcium ions are nutrients that play key roles in growth, differentiation and the production of bioactive secondary metabolites in filamentous fungi. Phosphate concentration regulates the biosynthesis of hundreds of fungal metabolites.
Juan F. Martín
doaj +1 more source
A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. [PDF]
PLoS ONE, 2016 Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches.
Brandi M Baughman +8 more
doaj +1 more source
Using organic phosphorus to sustain pasture productivity: A perspective [PDF]
, 2013 Organic phosphorus (P) in grazed pastures/grasslands could sustain production systems that historically relied on inorganic P fertiliser. Interactions between inorganic P, plants and soils have been studied extensively.
Condron, Leo M. +7 more
core +1 more source
Pathway of phytate dephosphorylation by β-propeller phytases of different origins [PDF]
, 2007 Using a combination of high-performance ion chromatography analysis and kinetic studies, the pathway of myo-inositol hexakisphosphate dephosphorylation by the P-propeller phytase of Shewanella oneidensis was established, which was then compared with that
Carlsson, NG +3 more
core +1 more source
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
Inositol Pyrophosphates Inhibit Synaptotagmin-Dependent Exocytosis [PDF]
Biophysical Journal, 2014 Inositol pyrophosphates such as IP7 (5-diphosphoinositol pentakisphosphate) are highly energetic inositol metabolites containing pyrophosphate bonds. While IP7 are known to regulate various biological events like metabolism, the molecular site of IP7 action in vesicle trafficking remains elusive.
Lee, TS Lee, Tae Sun +10 more
openaire +1 more source
Determination of phytic acid in urine by inductively coupled plasma mass spectrometry [PDF]
, 2005 The aim of this work is to provide a simple and accurate analytical procedure to easily determine phytic acid in urine, in contrast with time-consuming current ...
Muñoz Martínez, José Antonio +1 more
core +1 more source