Results 41 to 50 of about 5,995 (168)
Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression. [PDF]
mBio, 2022 Expression of the fission yeast phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate (IPP) signaling molecule 1,5-IP8.
Benjamin B +5 more
europepmc +2 more sources
Structural insight into inositol pyrophosphate turnover [PDF]
Advances in Biological Regulation, 2013 The diphosphoinositol polyphosphates ("inositol pyrophosphates"; PP-InsPs) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, insulin signaling and neutrophil activation.
Stephen B, Shears +2 more
openaire +2 more sources
Molecular Brain, 2020 Inositol phosphate metabolism has emerged as one of the key players in synaptic transmission. Previous studies have shown that the deletion of inositol hexakisphosphate kinase 1 (IP6K1), which is responsible for inositol pyrophosphate biosynthesis ...
Min-Gyu Kim +5 more
doaj +1 more source
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity. [PDF]
PLoS ONE, 2017 Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important
Michael Wormald +4 more
doaj +1 more source
Inositol pyrophosphates regulate endocytic trafficking [PDF]
Proceedings of the National Academy of Sciences, 2002 The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established.
Adolfo, Saiardi +4 more
openaire +2 more sources
The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System
Biomolecules, 2023 Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconvert ...
Tyler Heitmann, James C. Barrow
doaj +1 more source
Versatile signaling mechanisms of inositol pyrophosphates
Current Opinion in Chemical Biology, 2022 Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules ...
Minh Nguyen Trung +2 more
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Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis.
PLoS ONE, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani +5 more
doaj +1 more source
Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates [PDF]
Biochemistry, 2019 The inositol pyrophosphates (PP-InsPs) are an important group of cellular messengers that influence a broad range of biological processes. To elucidate the functions of these high-energy metabolites at the biochemical level, access to the purified molecules is required.
Robert Puschmann +2 more
openaire +2 more sources
Inositol Pyrophosphates Get the Vip1 Treatment [PDF]
Cell, 2007 Inositol pyrophosphates are unique signaling molecules implicated in the regulation of diverse cellular processes. Two new studies by Mulugu et al. (2007) and Lee et al. (2007) extend the biological and metabolic diversity of this class of molecules. They identify yeast Vip1 as a new inositol pyrophosphate synthase and show that the products of Vip1 ...
Onnebo, Sara Maria Nancy +1 more
openaire +2 more sources