Results 41 to 50 of about 58,667 (143)

A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine [PDF]

open access: yesOpen Biology, 2015
Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized.
Miranda S. C. Wilson   +4 more
doaj   +1 more source

Thiamine Diphosphate‐Dependent Biocatalysis in the 21st Century

open access: yesChemistry – A European Journal, EarlyView.
This account summarizes the major discoveries and recent advances, highlighting the biocatalytic abilities, mechanistic studies, and feature‐based classification that are shaping emerging perspectives on thiamine diphosphate (ThDP)‐dependent catalysis.
Lucrezia Lanza   +2 more
wiley   +1 more source

Interaction of calcium responsive proteins and transcriptional factors with the PHO regulon in yeasts and fungi

open access: yesFrontiers in Cell and Developmental Biology, 2023
Phosphate and calcium ions are nutrients that play key roles in growth, differentiation and the production of bioactive secondary metabolites in filamentous fungi. Phosphate concentration regulates the biosynthesis of hundreds of fungal metabolites.
Juan F. Martín
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

open access: yesAdvanced Science, Volume 13, Issue 59, 23 October 2026.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl   +20 more
wiley   +1 more source

Inositol Pyrophosphate Pyrotechnics

open access: yes, 2007
Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest.
Snyder, Solomon H.   +2 more
core   +1 more source

Cellular adaptations of fission yeast to inositol starvation

open access: yesmBio
Inositol is an essential nutrient and a precursor of phosphorylated metabolites that play important roles in cell physiology. Here we characterize the impact of intracellular inositol deficiency, taking advantage of fission yeast Schizosaccharomyces ...
Ana M. Sanchez   +6 more
doaj   +1 more source

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. [PDF]

open access: yesPLoS ONE, 2016
Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches.
Brandi M Baughman   +8 more
doaj   +1 more source

Population Genomic Analysis in Wild Medaka Populations: Identifying Candidate Loci for Balancing Selection

open access: yesEcology and Evolution, Volume 16, Issue 10, October 2026.
We explored genomic signatures of balancing selection and selective sweep in the northern medaka, Oryzias sakaizumii in Japan by performing whole‐genome resequencing of wild individuals. In addition, we reevaluated the population genetic structure and admixture of Oryzias latipes and O.
Shingo Fujimoto   +9 more
wiley   +1 more source

Nitrogen Fertilization Temporarily Enhances Phosphatase Activity in a High‐P Loamy Sand

open access: yesJournal of Plant Nutrition and Soil Science, Volume 189, Issue 5, Page 794-802, October 2026.
ABSTRACT Background Efficient plant utilization of soil phosphorus (P) is essential to reduce dependence on mineral P fertilizers in intensive agriculture. Input of mineral nitrogen (N) fertilizers and its chemical form may influence the activity of P mineralizing enzymes, but how this interaction operates under field conditions in a soil with high P ...
Ingeborg F. Pedersen   +3 more
wiley   +1 more source

Potential Phosphorus Uptake Mechanisms in the Deep Sedimentary Biosphere

open access: yesFrontiers in Marine Science, 2022
Our understanding of phosphorus (P) dynamics in the deep subseafloor environment remains limited. Here we investigate potential microbial P uptake mechanisms in oligotrophic marine sediments beneath the North Atlantic Gyre and their effects on the ...
Delphine Defforey   +8 more
doaj   +1 more source

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