Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast [PDF]
mBioThe inositol pyrophosphate signaling molecule 1,5-IP8 is an agonist of RNA 3'-processing and transcription termination in fission yeast that regulates the expression of phosphate acquisition genes pho1, pho84, and tgp1.
Lauren Bednor +4 more
doaj +2 more sources
β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner. [PDF]
Proc Natl Acad Sci U S A, 2023 These are the raw data used to generate all the figures presented in the manuscript "β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner".
Eisenbeis VB +12 more
europepmc +2 more sources
Inositol pyrophosphate kinases in health and disease. [PDF]
FEBS LettIn mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Xing C +6 more
europepmc +2 more sources
Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP<sub>5</sub>. [PDF]
Chem Sci, 2023 Inositol pyrophosphates are important biomolecules associated with apoptosis, cell growth and kinase regulation, yet their exact biological roles are still emerging and probes do not exist for their selective detection.
Shipton ML +6 more
europepmc +2 more sources
mBio, 2023 Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez +4 more
doaj +1 more source
Molecules, 2021 IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao +5 more
doaj +1 more source
Synthesis of novel phosphorothioate and pyrophosphate analysis of inositol phosphates.
, 1992 A novel synthesis of cyclic pyrophosphates was developed. The vicinal bisphosphorothioate, l-phenyl-ethane-l,2-bisphosphorothioate, was synthesised using phosphorus (III) chemistry.
Nicholas Jason. Noble (7697780)
core +4 more sources
Molecular Brain, 2020 Inositol phosphate metabolism has emerged as one of the key players in synaptic transmission. Previous studies have shown that the deletion of inositol hexakisphosphate kinase 1 (IP6K1), which is responsible for inositol pyrophosphate biosynthesis ...
Min-Gyu Kim +5 more
doaj +1 more source
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity. [PDF]
PLoS ONE, 2017 Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important
Michael Wormald +4 more
doaj +1 more source
The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System
Biomolecules, 2023 Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconvert ...
Tyler Heitmann, James C. Barrow
doaj +1 more source