Results 21 to 30 of about 13,047 (201)

Biosynthesis and possible functions of inositol pyrophosphates in plants [PDF]

Frontiers in Plant Science, 2015
Inositol phosphates (InsPs) are intricately tied to lipid signaling, as at least one portion of the inositol phosphate signaling pool is derived from hydrolysis of the lipid precursor, phosphatidyl inositol (4,5) bisphosphate. The focus of this review is
Sarah Phoebe Williams, Glenda E Gillaspy, Imara Yasmin Perera   +2 more
doaj   +4 more sources

Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast [PDF]

mBio
The inositol pyrophosphate signaling molecule 1,5-IP8 is an agonist of RNA 3'-processing and transcription termination in fission yeast that regulates the expression of phosphate acquisition genes pho1, pho84, and tgp1.
Lauren Bednor, Ana M. Sanchez, Angad Garg, Stewart Shuman, Beate Schwer   +4 more
doaj   +2 more sources

Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. [PDF]

Chemistry, 2023
AbstractInositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP in human cells. To investigate the function and regulation by PP−IPs in biological contexts,
Hostachy S, Wang H, Zong G, Franke K, Riley AM, Schmieder P, Potter BVL, Shears SB, Fiedler D.   +8 more
europepmc   +5 more sources

Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase

mBio, 2023
Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez, Beate Schwer, Nikolaus Jork, Henning J. Jessen, Stewart Shuman   +4 more
doaj   +1 more source

Inositol Pyrophosphate Pyrotechnics [PDF]

Cell Metabolism, 2007
Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest. In the April 6, 2007 issue of Science, two papers (Lee et al., 2007; Mulugu et al., 2007) demonstrate the occurrence of a novel inositol pyrophosphate molecule in yeast and elucidate its role in ...
Bhandari, Rashna, Chakraborty, Anutosh, Snyder, Solomon H.   +2 more
openaire   +2 more sources

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

Nature Communications, 2021
Plants regulate phosphate homeostasis via the interaction of PHR transcription factors with SPX receptors bound to inositol pyrophosphate signaling molecules.
Martina K. Ried, Rebekka Wild, Jinsheng Zhu, Joka Pipercevic, Kristina Sturm, Larissa Broger, Robert K. Harmel, Luciano A. Abriata, Ludwig A. Hothorn, Dorothea Fiedler, Sebastian Hiller, Michael Hothorn   +11 more
doaj   +1 more source

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +1 more source

Inositol pyrophosphates regulate endocytic trafficking [PDF]

Proceedings of the National Academy of Sciences, 2002
The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established.
Adolfo, Saiardi, Catherine, Sciambi, J Michael, McCaffery, Beverly, Wendland, Solomon H, Snyder   +4 more
openaire   +2 more sources

Preparation of Quality Inositol Pyrophosphates [PDF]

Journal of Visualized Experiments, 2011
Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP(5;)) and inositol hexakisphosphate (phytic acid or IP(6;)).
Loss, Omar, Azevedo, Cristina, Szijgyarto, Zsolt, Bosch, Daniel, Saiardi, Adolfo   +4 more
openaire   +2 more sources

Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory

Molecular Brain, 2020
Inositol phosphate metabolism has emerged as one of the key players in synaptic transmission. Previous studies have shown that the deletion of inositol hexakisphosphate kinase 1 (IP6K1), which is responsible for inositol pyrophosphate biosynthesis ...
Min-Gyu Kim, Seungjae Zhang, Hoyong Park, Seung Ju Park, Seyun Kim, ChiHye Chung   +5 more
doaj   +1 more source