Results 21 to 30 of about 5,995 (168)

Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks [PDF]

Animal Cells and Systems, 2018
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seung Eun Park, Seyun Kim   +3 more
doaj   +5 more sources

Elevation of inositol pyrophosphate IP₇ in the mammalian spinal cord of amyotrophic lateral sclerosis. [PDF]

Front Neurol, 2023
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive impairment of spinal motor neurons. Continuous research endeavor is underway to fully understand the molecular mechanisms associating with ...
Ito M, Fujii N, Kohara S, Tanaka M, Takao M, Mihara B, Saito Y, Mizuma A, Nakayama T, Netsu S, Suzuki N, Kakita A, Nagata E.   +12 more
europepmc   +2 more sources

Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate. [PDF]

Nat Commun
Inorganic phosphate (Pi) is essential for life, and its intracellular levels must be tightly regulated to avoid toxicity. XPR1, the sole known phosphate exporter, is critical for maintaining this balance.
Zuo P, Wang W, Dai Z, Zheng J, Yu S, Wang G, Yin Y, Liang L, Yin Y.   +8 more
europepmc   +3 more sources

β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner. [PDF]

Proc Natl Acad Sci U S A, 2023
Significance Inositol pyrophosphates (PP-InsPs) are messenger molecules regulating various functions in mammals. They are associated with the oxidative stress response, but the underlying mechanism is unclear.
Eisenbeis VB, Qiu D, Gorka O, Strotmann L, Liu G, Prucker I, Su XB, Wilson MSC, Ritter K, Loenarz C, Groß O, Saiardi A, Jessen HJ.   +12 more
europepmc   +2 more sources

Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants. [PDF]

PLoS Genet
Inositol pyrophosphates (PP-InsPs) are soluble cellular messengers that integrate environmental cues to induce adaptive responses in eukaryotes. In plants, the biological functions of various PP-InsP species are poorly understood, largely due to the ...
Yadav R, Liu G, Rana P, Pullagurla NJ, Qiu D, Jessen HJ, Laha D.   +6 more
europepmc   +2 more sources

Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling. [PDF]

Biomed Pharmacother, 2023
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the mechanisms of action have been elusive. Here we report that itraconazole disrupts focal adhesion dynamics and cytoskeletal remodeling, which requires 5 ...
Qi J, Cheng W, Gao Z, Chen Y, Shipton ML, Furkert D, Chin AC, Riley AM, Fiedler D, Potter BVL, Fu C.   +10 more
europepmc   +2 more sources

A linear pathway for inositol pyrophosphate metabolism revealed by 18O labeling and model reduction. [PDF]

PLoS Comput Biol
The homeostasis of intracellular inorganic phosphate is essential for eukaryotic metabolism and is regulated by the INPHORS signalling pathway, which employs inositol pyrophosphates (IPPs) as key intermediary messengers.
Hermes J, Kim GD, Liu G, De Leo MG, Mayer A, Jessen H, Timmer J.   +6 more
europepmc   +2 more sources

Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP-InsP₄ Isomers in Plant Signaling. [PDF]

Angew Chem Int Ed Engl
Inositol pyrophosphates (PP‐InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despite extensive research on well‐characterized exhaustively
Ritter K, Braun AC, Liu G, Lu M, Gaugler V, Schaaf G, Jessen HJ.   +6 more
europepmc   +2 more sources

Enhancing inositol pyrophosphate accumulation in plants alters growth, phosphate homeostasis, and insect herbivory. [PDF]

Plant J
SUMMARY Phosphate (Pi) is a critical nutrient for plants and is often a limiting factor in food production, as many agricultural soils are limited in available Pi.
Cridland C, Russo A, Craige B, Donahue J, Zhang XM, Payne M, Gillaspy G, Freed C.   +7 more
europepmc   +2 more sources

Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase

mBio, 2023
Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez, Beate Schwer, Nikolaus Jork, Henning J. Jessen, Stewart Shuman   +4 more
doaj   +1 more source