Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs [PDF]
Chemistry - A European Journal, 2023 Inositol pyrophosphates (PP-IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP-IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo-inositol ring. 5PP-IP5 is the most abundant PP-IP
Guangning Zong +2 more
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Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis. [PDF]
PLoS ONE, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani +5 more
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Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis. [PDF]
PLoS ONE, 2009 BackgroundInositol pyrophosphates are a recently characterized cell signalling molecules responsible for the pyrophosphorylation of protein substrates. Though likely involved in a wide range of cellular functions, the study of inositol pyrophosphates has
Oriana Losito +3 more
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Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis [PDF]
Nature Communications, 2021 Plants regulate phosphate homeostasis via the interaction of PHR transcription factors with SPX receptors bound to inositol pyrophosphate signaling molecules.
Martina K. Ried +11 more
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Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies
Advanced ScienceInositol phosphates (InsPs) and inositol pyrophosphates (PP‐InsPs) constitute a remarkably diverse yet evolutionarily conserved signaling network generated through combinatorial phosphorylation of myo‐inositol.
Adolfo Saiardi +5 more
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Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses [PDF]
iScience, 2020 Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park +6 more
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Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast [PDF]
mBio, 2022 Inositol pyrophosphate (IPP) dynamics govern expression of the fission yeast phosphate homeostasis regulon via their effects on lncRNA-mediated transcription interference.
Beate Schwer +5 more
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Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis [PDF]
eLife, 2019 Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis.
Jinsheng Zhu +14 more
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Animal Cells and Systems, 2018 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seyun Kim
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Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers. [PDF]
Biochemistry, 2022 Inositol pyrophosphates are signaling molecules containing at least one phosphoanhydride bond that regulate a wide range of cellular processes in eukaryotes.
Gaugler P +17 more
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