Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast [PDF]
mBio, 2022 Inositol pyrophosphate (IPP) dynamics govern expression of the fission yeast phosphate homeostasis regulon via their effects on lncRNA-mediated transcription interference.
Beate Schwer +5 more
doaj +4 more sources
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective [PDF]
Trends in Biochemical Sciences, 2017 Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated.
Azevedo, C, Saiardi, A
core +7 more sources
Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants [PDF]
The Plant Journal, 2014 SummaryInositol pyrophosphates are unique cellular signaling molecules with recently discovered roles in energy sensing and metabolism. Studies in eukaryotes have revealed that these compounds have a rapid turnover, and thus only small amounts accumulate.
Mintu, Desai +9 more
openaire +4 more sources
Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses [PDF]
iScience, 2020 Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park +6 more
doaj +2 more sources
The inositol pyrophosphate pathway in health and diseases. [PDF]
Biol Rev Camb Philos Soc, 2018 ABSTRACTInositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs ...
Chakraborty A.
europepmc +6 more sources
Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks [PDF]
Animal Cells and Systems, 2018 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park +3 more
doaj +4 more sources
Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis [PDF]
eLife, 2019 Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis.
Jinsheng Zhu +14 more
doaj +2 more sources
Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis [PDF]
BMC Biology, 2021 Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla +12 more
doaj +2 more sources
Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate [PDF]
Nature CommunicationsInorganic phosphate (Pi) is essential for life, and its intracellular levels must be tightly regulated to avoid toxicity. XPR1, the sole known phosphate exporter, is critical for maintaining this balance.
Peng Zuo +8 more
doaj +2 more sources
Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1 [PDF]
mBioInositol pyrophosphates are signaling molecules that regulate cellular phosphate homeostasis in eukaryal taxa. In fission yeast, where the phosphate regulon (comprising phosphate acquisition genes pho1, pho84, and tgp1) is repressed under phosphate ...
Beate Schwer +4 more
doaj +2 more sources