Results 11 to 20 of about 5,995 (168)

Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs [PDF]

Chemistry - A European Journal, 2023
AbstractInositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP in human cells. To investigate the function and regulation by PP−IPs in biological contexts,
Sarah Hostachy, Huanchen Wang, Guangning Zong   +2 more
exaly   +7 more sources

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8 [PDF]

Cell Reports
SUMMARY Phosphate (Pi) serves countless metabolic pathways and is involved in macromolecule synthesis, energy storage, cellular signaling, and bone maintenance.
Xingyao Li, Anuj Shukla, Henning J Jessen   +2 more
exaly   +3 more sources

The inositol pyrophosphate pathway in health and diseases [PDF]

Biological Reviews, 2018
ABSTRACTInositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs ...
Anutosh Chakraborty
exaly   +5 more sources

Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development. [PDF]

PLoS Genetics
Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Florian Laurent, Simon M Bartsch, Anuj Shukla, Felix Rico-Resendiz, Daniel Couto, Christelle Fuchs, Joël Nicolet, Sylvain Loubéry, Henning J Jessen, Dorothea Fiedler, Michael Hothorn   +10 more
doaj   +2 more sources

Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases [PDF]

Molecules, 2020
In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee, Jake Haubner, Anutosh Chakraborty   +2 more
doaj   +2 more sources

Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus [PDF]

The EMBO Journal
Kinases that synthesize inositol phosphates (IPs) and pyrophosphates (PP-IPs) control numerous biological processes in eukaryotic cells. Herein, we extend this cellular signaling repertoire to viruses. We have biochemically and structurally characterized
Guangning Zong, Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B. Shears, Huanchen Wang   +6 more
doaj   +2 more sources

Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses [PDF]

iScience, 2020
Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park, Hoyong Park, Min-Gyu Kim, Seungjae Zhang, Seung Eun Park, Seyun Kim, ChiHye Chung   +6 more
doaj   +2 more sources

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis [PDF]

eLife, 2019
Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis.
Jinsheng Zhu, Kelvin Lau, Robert Puschmann, Robert K Harmel, Youjun Zhang, Verena Pries, Philipp Gaugler, Larissa Broger, Amit K Dutta, Henning J Jessen, Gabriel Schaaf, Alisdair R Fernie, Ludwig A Hothorn, Dorothea Fiedler, Michael Hothorn   +14 more
doaj   +2 more sources

Biosynthesis and possible functions of inositol pyrophosphates in plants [PDF]

Frontiers in Plant Science, 2015
Inositol phosphates (InsPs) are intricately tied to lipid signaling, as at least one portion of the inositol phosphate signaling pool is derived from hydrolysis of the lipid precursor, phosphatidyl inositol (4,5) bisphosphate. The focus of this review is
Sarah Phoebe Williams, Glenda E Gillaspy, Imara Yasmin Perera   +2 more
doaj   +4 more sources

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis [PDF]

BMC Biology, 2021
Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla, Mandeep Kaur, Swati Kanwar, Gazaldeep Kaur, Shivani Sharma, Shubhra Ganguli, Vandana Kumari, Koushik Mazumder, Pratima Pandey, Hatem Rouached, Vikas Rishi, Rashna Bhandari, Ajay Kumar Pandey   +12 more
doaj   +2 more sources