Results 101 to 110 of about 5,995 (168)

Dimensional Assembly Engineering of Ce‐MOF Interfaces for Selective Recognition of Phytic Acid

open access: yesRare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Selective molecular recognition is central to chemical sensing yet discriminating structurally similar molecules at complex interfaces remains challenging. Traditional strategies based on tuning size, charge, or binding‐site chemistry often suffer from limited flexibility.
Qiang Miao   +7 more
wiley   +1 more source

Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase

open access: yesmBio
Inositol pyrophosphate 1,5-IP8 regulates expression of a fission yeast phosphate homeostasis regulon, comprising phosphate acquisition genes pho1, pho84, and tgp1, via its action as an agonist of precocious termination of transcription of the upstream ...
Shreya Ghosh   +6 more
doaj   +1 more source

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery

open access: yesJournal of Fungi, 2016
Opportunistic fungi are a major cause of morbidity and mortality world-wide, particularly in immunocompromised individuals. Developing new treatments to combat invasive fungal disease is challenging given that fungal and mammalian host cells are ...
Cecilia Li   +5 more
doaj   +1 more source

Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies

open access: yesJournal of Neurochemistry, Volume 170, Issue 5, May 2026.
Chromaffin cells and platelets both utilize exocytosis to release biogenic amines stored within large dense‐core vesicles—specifically chromaffin granules (epinephrine) and δ‐granules (serotonin). While the chromaffin cell is the foundational model for studying the secretory pathway, platelets offer a highly accessible human cell source for clinical ...
Ricardo Borges
wiley   +1 more source

The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA

open access: yesNature Communications
The response of plants to phosphate starvation engages PHR (CC-MYB-PHOSPHATE STARVATION RESPONSE) transcription factors that bind to P1BS (GNATATNC) promoter elements of phosphate-starvation induced (PSI) genes. The encoded proteins include single-domain
Hayley L. Whitfield   +6 more
doaj   +1 more source

Inositol biosynthesis is fine‐tuned by inositol pyrophosphates in Saccharomyces cerevisiae

open access: yesThe FASEB Journal, 2013
In yeast , inositol biosynthesis is coordinated with the synthesis of phospholipids by controlling the expression of enzymes in the biosynthetic pathways. Inositol pyrophosphates, most recently characterized in the inositide family, have diverse roles in phosphate signaling and other ...
Cunqi Ye, Miriam L Greenberg
openaire   +1 more source

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.

open access: yesPLoS ONE, 2016
The HCT116 cell line, which has a pseudo-diploid karotype, is a popular model in the fields of cancer cell biology, intestinal immunity, and inflammation.
Chunfang Gu   +4 more
doaj   +1 more source

Inositol Pyrophosphates and Phosphate Sensing in Plants

open access: yesThe FASEB Journal, 2019
Phosphate (P i ) is an essential nutrient for plants, required for plant growth and seed viability. Under P i stress, plants undergo dynamic changes to leverage available P i .
Glenda Gillaspy   +7 more
openaire   +1 more source

Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability

open access: yesMolecular Brain
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin   +5 more
doaj   +1 more source

Unveiling the Plasmodium inositol (pyro)phosphate pathway: Highlighting inositol polyphosphate multikinase as a novel therapeutic target for malaria.

open access: yesPLoS ONE
Plasmodium falciparum malaria is fatal if left untreated. Treatment is hampered by drug-resistant variants of the malaria parasite, highlighting the need to explore unique pathways for the development of new drugs with different mechanisms of action ...
Abigail Obuobi   +3 more
doaj   +1 more source

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