Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability
Molecular BrainInositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin +5 more
doaj +1 more source
Cigarette Smoke (CS) and Nicotine Delay Neutrophil Spontaneous Death via Suppressing Production of Diphosphoinositol Pentakisphosphate [PDF]
, 2014 Diphosphoinositol pentakisphosphate (InsP7), a higher inositol phosphate containing energetic pyrophosphate bonds, is beginning to emerge as a key cellular signaling molecule.
Bajrami, Besnik +10 more
core +1 more source
Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity [PDF]
, 2013 Using a newly developed near-infrared (NIR) dye that fluoresces at two different wavelengths (dichromic fluorescence, DCF), we discovered a new fluorescent substrate for Akt, also known as protein kinase B, and a method to quantitatively report this ...
Achilefu, Samuel +6 more
core +3 more sources
The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. [PDF]
, 1992 The MRC OX-44 molecule, which is expressed on all peripheral leukocytes, identifies the subset of thymocytes capable of proliferating in response to alloantigens and lectins (Paterson, D.J., J.R. Green, W.A. Jefferies, M. Puklavec, and A.F.
Bell, GM +3 more
core +2 more sources
Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response. [PDF]
, 2018 In Trypanosoma brucei and related kinetoplastid parasites, transcription of protein coding genes is largely unregulated. Rather, mRNA binding proteins, which impact processes such as transcript stability and translation efficiency, are the predominant ...
Debler, Erik W. +7 more
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PLoS ONEPlasmodium falciparum malaria is fatal if left untreated. Treatment is hampered by drug-resistant variants of the malaria parasite, highlighting the need to explore unique pathways for the development of new drugs with different mechanisms of action ...
Abigail Obuobi +3 more
doaj +1 more source
A comparative study of the phosphorus characteristics of oil palm volcanic soils in Papua New Guinea and New Zealand volcanic soils : a thesis presented in partial fulfillment of the requirements for the Degree of Master of Applied Science in Soil Science at Massey University [PDF]
, 1998 Oil Palm (Elaeis guineensis Jacq.) grown on volcanic ash soils in Papua New Guinea (PNG) generally respond well to N fertilisers but shows a lack of consistent response to inorganic phosphorus (P) fertilisers.
Banabas, Murom
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Elevation of inositol pyrophosphate IP7 in the mammalian spinal cord of amyotrophic lateral sclerosis. [PDF]
Front Neurol, 2023 Ito M +12 more
europepmc +1 more source
Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1
Nature CommunicationsInorganic phosphate (Pi) has essential metabolic and structural roles in living organisms. The Pi exporter, XPR1/SLC53A1, is critical for cellular Pi homeostasis.
Qinyu Zhu +4 more
doaj +1 more source
The plant Nudix hydrolase family. [PDF]
, 2008 Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
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