Results 141 to 150 of about 5,995 (168)

Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.

Science
Precise regulation of intracellular phosphate (Pi) is critical for cellular function, with XPR1 serving as the sole Pi exporter in humans. The mechanism of Pi efflux, activated by inositol pyrophosphates (PP-IPs), has remained unclear.
Yi Lu, Chen-Xi Yue, Li Zhang, Deqiang Yao, Ying Xia, Qing Zhang, Xinchen Zhang, Shaobai Li, Yafeng Shen, Mi Cao, Chang-Run Guo, An Qin, Jie Zhao, Lu Zhou, Ye Yu, Yu Cao   +15 more
semanticscholar   +1 more source

A Discrete Signaling Function for an Inositol Pyrophosphate

Science's STKE, 2007
Inositol pyrophosphates were, until recently, without clearly defined functions. Two recent papers in Science have now clearly defined a function for an IP 7 pyrophosphate (inositol hexaphosphate with one pyrophosphate) that is the product of the enzyme encoded by the Vip1
openaire   +2 more sources

Cell Signalling by Inositol Pyrophosphates

2012
Inositol serves as a module for the generation of a high level of molecular diversity through the combinatorial attachment and removal of phosphate groups. The array of potential inositol-containing molecules is further expanded by the generation of diphospho inositol polyphosphates, commonly referred as inositol pyrophosphates.
openaire   +2 more sources

Enzymatic Synthesis of Inositol Pyrophosphates

The availability of well-defined and pure PP-InsP substrates in high quantities is pivotal to study their molecular mechanisms by means of biochemical or biophysical approaches. Here, we present a workflow employing enzymatic synthesis that allows for the quick and easy synthesis and isolation of mammalian PP-InsP isomers.
Simon M, Bartsch, Dorothea, Fiedler
openaire   +2 more sources

Inositol Pyrophosphates in Metabolism Control

Science Signaling, 2011
Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
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Influence of Inositol Pyrophosphates on Cellular Energy Dynamics

Science, 2011
Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
Zsolt, Szijgyarto, Assegid, Garedew, Cristina, Azevedo, Adolfo, Saiardi   +3 more
openaire   +2 more sources

Functional Conservation of the DDP1-type Inositol Pyrophosphate Phosphohydrolases in Land Plant.

Biochemistry
Inositol pyrophosphates (PP-InsPs) are eukaryote-specific second messengers that regulate diverse cellular processes, including immunity, nutrient sensing, and hormone signaling pathways in plants. These energy-rich messengers exhibit high sensitivity to
Kuheli Chalak, Ranjana Yadav, Guizhen Liu, Priyanshi Rana, H. Jessen, D. Laha   +5 more
semanticscholar   +1 more source

The inositol pyrophosphates are essential for the development of mammals [PDF]

, 2022
Inositol polyphosphates, generated from a second messenger IP3 by a series of kinases, are a family of endogenous metabolites conserved across evolution. Inositol polyphosphates participate in diverse physiological activities, including insulin secretion, ubiquitination, apoptosis, cancer development.
openaire  

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

Biomolecules, 2023
Soumyadip Sahu, Jacob Gordon, Chunfang Gu   +2 more
exaly  

Cell Extraction and Enrichment of Inositol Polyphosphate and Inositol Pyrophosphates Using Titanium Dioxide

Inositol polyphosphates are ubiquitously present in eukaryotic cells and play important roles in diverse cellular processes such as protein folding, signal transduction, and phosphate homeostasis. Although these negatively charged small metabolites are easily stripped from metals/proteins and extracted under strong acidic conditions, their low ...
Xue Bessie, Su, Amina, Mudhaffer, Adolfo, Saiardi   +2 more
openaire   +2 more sources