Results 131 to 140 of about 13,047 (201)

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

Nature Communications
Inositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenger 1,5-InsP8, the C-terminal phosphatase domain catalyzes PP-InsP breakdown ...
Pierre Raia, Kitaik Lee, Simon M. Bartsch, Felix Rico-Resendiz, Daniela Portugal-Calisto, Oscar Vadas, Vikram Govind Panse, Dorothea Fiedler, Michael Hothorn   +8 more
doaj   +1 more source

β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner. [PDF]

Proc Natl Acad Sci U S A, 2023
Eisenbeis VB, Qiu D, Gorka O, Strotmann L, Liu G, Prucker I, Su XB, Wilson MSC, Ritter K, Loenarz C, Groß O, Saiardi A, Jessen HJ.   +12 more
europepmc   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio
Dimethylsulfoxide (DMSO) is widely used as a solvent or as a carrier when screening for biologic activity of various chemicals, but results need to be interpreted carefully due to its intrinsic toxicity.
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
doaj   +1 more source

How inositol pyrophosphates control cellular phosphate homeostasis?

Advances in Biological Regulation, 2012
Phosphorus in his phosphate PO(4)(3-) configuration is an essential constituent of all life forms. Phosphate diesters are at the core of nucleic acid structure, while phosphate monoester transmits information under the control of protein kinases and phosphatases.
openaire   +3 more sources

Envelliment i calcificació de teixits blans: des de la patologia cardiovascular a l’alzheimer [PDF]

La majoria de teixits del cos humà progressivament es van calcificant amb l’edat, encara que el grau de calcificació depèn en gran mesura de cada individu.
Costa Bauzà, Antònia, Grases Freixedas, Fèlix   +1 more
core  

Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers. [PDF]

Biochemistry, 2022
Gaugler P, Schneider R, Liu G, Qiu D, Weber J, Schmid J, Jork N, Häner M, Ritter K, Fernández-Rebollo N, Giehl RFH, Trung MN, Yadav R, Fiedler D, Gaugler V, Jessen HJ, Schaaf G, Laha D.   +17 more
europepmc   +1 more source

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in <i>S. pombe</i>. [PDF]

J Fungi (Basel), 2022
Kuenzel NA, Alcázar-Román AR, Saiardi A, Bartsch SM, Daunaraviciute S, Fiedler D, Fleig U.   +6 more
europepmc   +1 more source

Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling. [PDF]

Biomed Pharmacother, 2023
Qi J, Cheng W, Gao Z, Chen Y, Shipton ML, Furkert D, Chin AC, Riley AM, Fiedler D, Potter BVL, Fu C.   +10 more
europepmc   +1 more source

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP₇ metabolism in the enteric nervous system. [PDF]

J Biol Chem, 2023
Ito M, Fujii N, Kohara S, Hori S, Tanaka M, Wittwer C, Kikuchi K, Iijima T, Kakimoto Y, Hirabayashi K, Kurotaki D, Jessen HJ, Saiardi A, Nagata E.   +13 more
europepmc   +1 more source

Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP₅. [PDF]

Chem Sci, 2023
Shipton ML, Jamion FA, Wheeler S, Riley AM, Plasser F, Potter BVL, Butler SJ.   +6 more
europepmc   +1 more source