XPR1 mediates the pancreatic B-cell phosphate flush [PDF]
, 2020 Glucose-stimulated insulin secretion is the hallmark of the pancreatic β-cell, a critical player in the regulation of blood glucose concentration.
Berggren +17 more
core +2 more sources
Journal of Extracellular Vesicles, Volume 13, Issue 5, May 2024.Schematic description of AKT/mTORC1 pathway supression by Taenia solium derived EV particles on macrophages. Abstract The excretory–secretory proteome plays a pivotal role in both intercellular communication during disease progression and immune escape mechanisms of various pathogens including cestode parasites like Taenia solium.
Suraj Singh Rawat +6 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2014, Issue 1, 2014., 2014 Nitric oxide (NO) deficiency is involved in the development of hypertension, a condition that can originate early in life. We examined whether NO deficiency contributed to programmed hypertension in offspring from mothers with calorie‐restricted diets and whether melatonin therapy prevented this process.
You-Lin Tain +4 more
wiley +1 more source
Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling [PDF]
, 2017 Inositol polyphosphates, in their water-soluble or lipid-bound forms, represent a large and multifaceted family of signalling molecules. Some inositol polyphosphates are well recognised as defining important signal transduction pathways, as in the case ...
Saiardi, A, Wilson, MSC
core
Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system [PDF]
, 2023 Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important.
Fujii, Natsuko +13 more
core
Analysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis. [PDF]
, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Chubb, JR +5 more
core
Genome-wide DNA methylation in saliva and body size of adolescent girls [PDF]
, 2016 Aim: We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its association with BMI in adolescents.
Andreassen, Bettina K. +5 more
core +3 more sources
Characterization of Inorganic Polyphosphate in Mammalian Cells [PDF]
, 2020 Inorganic polyphosphate (polyP) is a linear chain of three to around one thousand orthophosphates linked by phosphoanhydride bonds. Not only is polyP considered as a “molecular fossil” that existed on the primordial earth, but it is also universally ...
Xie, Lihan
core
Interplay between PFBC-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis [PDF]
, 2020 Solute carrier family 20 member 2 (SLC20A2) and xenotropic and polytropic retrovirus receptor 1 (XPR1) are transporters with phosphate uptake and efflux functions, respectively.
Ayrignac, X +9 more
core
Exome-wide association study of pancreatic cancer risk [PDF]
, 2018 We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic
Biankin, Andrew +18 more
core +1 more source