Results 101 to 110 of about 1,062 (145)

Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors. [PDF]

ACS Med Chem Lett, 2023
Heitmann T, Liao G, de León P, Ernst G, Buchler I, Wei H, Shlevkov E, Brown D, Fitzek M, Collier M, Smith DM, Barrow JC.   +11 more
europepmc   +1 more source

Inositol hexakisphosphate kinase-1 (IP6K1) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Harnessing {13}^C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR [PDF]

, 2019
Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are an important group of metabolites and mediate a wide range of processes in eukaryotic cells. To elucidate the functions of these molecules, robust techniques for the characterization of inositol ...
Fiedler, D, Harmel, RK, Nguyen Trung, M, Puschmann, R, Saiardi, A, Schmieder, P   +5 more
core  

IP6K1 interacts with the syndecan SDC4 to support secretory granule biogenesis in gastric chief cells

ABSTRACT Inositol hexakisphosphate kinases (IP6Ks) catalyse the synthesis of the inositol pyrophosphate 5-InsP7, and regulate diverse physiological processes. Mice lacking IP6K1 display reduced body weight despite normal food intake, a phenotype that is more apparent in juvenile mice during their rapid growth phase. Additionally, Ip6k1
Jayraj Sen, Pranjali Pore, Rashna Bhandari   +2 more
openaire   +1 more source

Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling. [PDF]

Biomed Pharmacother, 2023
Qi J, Cheng W, Gao Z, Chen Y, Shipton ML, Furkert D, Chin AC, Riley AM, Fiedler D, Potter BVL, Fu C.   +10 more
europepmc   +1 more source

Estudio cristalográfico de proteínas implicadas en la ruta de los inositoles polifosfatados y su relación con el ARN [PDF]

, 2018
Los inositoles polifosfatados (IPs) son un amplio y diverso grupo de pequeñas moléculas solubles que desempeñan papeles biológicos en señalización celular y procesos metabólicos.
Franco Echevarría, Elsa
core   +1 more source

Inositol hexakinase phosphate 1 (IP6K1) is implicated in the insulin response to protein ingestion in older adults

Abstract Age-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle with inositol hexokinase phosphate 1 (IP6K1) shown to inhibit this signalling pathway in pre-diabetic humans.
Richie D. Barclay, Diana E. Motei, Oana Ancu, Christopher J. Tyler, Neale A. Tillin, Volker Behrends, Nicholas A. Burd, Nicholas M. Hurren, Richard W.A. Mackenzie   +8 more
openaire   +1 more source

Molecular genetic analysis of boar taint [PDF]

, 2012
Boar taint is an unpleasant smell and taste of pork meat derived from some entire male pigs. The main causes of boar taint are the two compounds androstenone (5α-androst-16-en-3-one) and skatole (3-methylindole). It is crucial to understand the genetic
Cinar, Mehmet Ulas, Frieden, Luc, Große-Brinkhaus, Christine, Gunawan, Asep, Looft, Christian, Neuhoff, Christiane, Pröll, Maren, Schellander, Karl, Tholen, Ernst   +8 more
core  

Strategies Toward Inhibition of Inositol Hexakisphosphate Kinase [PDF]

Inositol is a unique biological small molecule as a cyclohexane ring with stereochemically defined hydroxyl groups on all six carbons of the ring.
Heitmann, Tyler Eric
core   +3 more sources

The Role of the Inositol Hexakisphosphate Kinase-1 (IP6K1) in Anabolic Signalling in Man. [PDF]

, 2022
Barclay, Richie
core