Results 121 to 130 of about 737 (136)
Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction [PDF]
International Journal of Molecular Sciences, 2022 (1) Background: We previously demonstrated that disruption of IP6K1 improves metabolism, protecting mice from high-fat diet-induced obesity, insulin resistance, and non-alcoholic fatty liver disease and steatohepatitis. Age-induced metabolic dysfunction is a major risk factor for metabolic diseases. The involvement of IP6K1 in this process is unknown. (
Anutosh Chakraborty +2 more
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Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport [PDF]
Biochemical Journal, 2016 Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are conserved eukaryotic signaling molecules that possess pyrophosphate and monophosphate moieties. Generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine pyrophosphorylation. Here,
Roop Mallik +2 more
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Synthesis and characterization of novel isoform-selective IP6K1 inhibitors
Bioorganic and Medicinal Chemistry Letters, 2019 Inositol hexakisphosphate kinases (IP6Ks) have been increasingly studied as therapeutically interesting enzymes. IP6K isoform specific knock-outs have been used to successfully explore inositol pyrophosphate physiology and related pathologies. A pan-IP6K inhibitor, N2-(m-trifluorobenzyl)-N6-(p-nitrobenzyl) purine (TNP), has been used to confirm ...
James Barrow, Huijun Wei, Glen Ernst
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Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells* ♦ [PDF]
Journal of Biological Chemistry, 2016 myo-Inositol, the precursor of all inositol compounds, has pivotal roles in cell metabolism and signaling pathways. Although physiological studies indicate a strong correlation between abnormal intracellular inositol levels and neurological disorders, very little is known about the regulation of inositol synthesis in mammalian cells.
Miriam L Greenberg, Wenxi Yu
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Inositol hexakisphosphate kinase-1 (IP6K1) [PDF]
Science-Business EXchange, 2011 exaly +2 more sources
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Synthesis of InsP 7 by the Inositol Hexakisphosphate Kinase 1 (IP6K1)
Methods in Molecular Biology, 2010Soluble inositol polyphosphates represent a variegate class of signalling molecules essential for the function of disparate cellular processes. Recently, the phytic acid derivate inositol pyrophosphate, InsP(7) (PP-IP(5) or IP(7)) has been shown to pyro-phosphorylate proteins in a kinase independent way. To begin to understand the functional importance
Adolfo Saiardi +2 more
exaly +3 more sources
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting
Cancer Letters, 2021The deregulation of PI3K/Akt signaling is among the most causes in inducing the acquisition of a metastatic phenotype in breast cancer cells, leading to Epithelial-Mesenchymal Transition (EMT). Inhibition of the PI3K/Akt pathway is known to be beneficial in the clinical setting.
Minini M. +11 more
openaire +2 more sources
Science Signaling, 2014
UV light prevents the inhibition of the E3 ubiquitin ligase complex CRL4 by IP6K1.
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UV light prevents the inhibition of the E3 ubiquitin ligase complex CRL4 by IP6K1.
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Blood
Abstract Background: Cancer-associated thrombosis (CAT) is driven by multiple procoagulant mechanisms. Immune checkpoint inhibitors (ICI), while enhancing antitumor immunity, are linked to an increased risk of thrombosis (ICI-associated thrombosis, IAT).
Young Jun Shim +2 more
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Abstract Background: Cancer-associated thrombosis (CAT) is driven by multiple procoagulant mechanisms. Immune checkpoint inhibitors (ICI), while enhancing antitumor immunity, are linked to an increased risk of thrombosis (ICI-associated thrombosis, IAT).
Young Jun Shim +2 more
openaire +1 more source