Results 61 to 70 of about 737 (136)

RETRACTED: Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, Volume 159, Issue 5, Page E1-E13, 1 September 2026.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

Molecular mechanisms of perilipin protein function in lipid droplet metabolism

FEBS Letters, Volume 598, Issue 10, Page 1170-1198, May 2024.
Lipid droplets (LDs) are important for the storage of energy and lipid components. The perilipin family in mammals includes five proteins (PLIN1 to PLIN5), all of which are abundant on the surface of LDs in different tissues and play a role in LD stability and degradation by lipases.
Elena Griseti, Abdoul Akim Bello, Eric Bieth, Bayane Sabbagh, Jason S. Iacovoni, Joëlle Bigay, Henrik Laurell, Alenka Čopič   +7 more
wiley   +1 more source

Taenia solium cysticerci's extracellular vesicles Attenuate the AKT/mTORC1 pathway for Alleviating DSS‐induced colitis in a murine model

Journal of Extracellular Vesicles, Volume 13, Issue 5, May 2024.
Schematic description of AKT/mTORC1 pathway supression by Taenia solium derived EV particles on macrophages. Abstract The excretory–secretory proteome plays a pivotal role in both intercellular communication during disease progression and immune escape mechanisms of various pathogens including cestode parasites like Taenia solium.
Suraj Singh Rawat, Anand Kumar Keshri, Naina Arora, Rimanpreet Kaur, Amit Mishra, Rajiv Kumar, Amit Prasad   +6 more
wiley   +1 more source

Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels

, 2013
Polyphosphate (polyP), a polymer of orthophosphate moieties released from the dense granules of activated platelets, is a procoagulant agent. Inositol pyrophosphates, another group of phosphate-rich molecules, consist of mono- and diphosphates ...
Shukla, Dhananjay, Suman, Komjeti, Lakshmi, B. Jyothi, Manorama, R., Kumar, Satish, Bhandari, Rashna, Ghosh, Somadri   +6 more
core   +1 more source

Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity [PDF]

, 2019
Background We have recently shown that a novel signalling kinase, inositol hexakisphosphate kinase 1 (IP6K1), is implicated in whole-body insulin resistance via its inhibitory action on Akt.
Tillin, Neale A., Mackenzie, Richard, Imai, Brian S., De Lisio, Michael, Barclay, Richie, Yau, Peter M., Villegas-Montes, Martha, Mackenzie, Richard W., Watt, Peter W., Drnevich, Jenny, Paluska, Scott A., Burd, Nicholas A., Watt, Peter; id_orcid, Burd, Nichlolas A., Barclay, Richie D., Tillin, Neale; id_orcid, Beals, Joseph W., Ulanov, Alexander V.   +17 more
core   +1 more source

Polyphosphate synthesis in mast cell granules relies on V-ATPase activity supported by IP6K1

Polyphosphate (polyP), a linear polymer of orthophosphate residues, is enriched in secretory granules in specialised mammalian cell types including platelets and mast cells.
Rashna Bhandari, Manisha Mallick
core   +1 more source

IP6K1 interacts with the syndecan SDC4 to support secretory granule biogenesis in gastric chief cells

American Journal of Physiology-Gastrointestinal and Liver Physiology
Through detailed phenotypic analysis of Ip6k1 − / − mice and mechanistic studies, we identify IP6K1 as a key regulator of digestive enzyme granule biogenesis and secretion in gastric glands.
Jayraj Sen, Pranjali Pore, Rashna Bhandari   +2 more
openaire   +1 more source

Inositol pyrophosphates drive sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α [PDF]

, 2020
Sodium/potassium-transporting adenosine triphosphatase (Na+/K+-ATPase) is one of the most abundant cell membrane proteins and is essential for eukaryotes.
Alfred C. Chin, Fu, Chenglai, Solomon H. Snyder, Furkert, David, Dutta, Amit K., Chenglai Fu, Jennifer L. Pluznick, Henning J. Jessen, Fiedler, Dorothea, Potter, Barry, Barry V. L. Potter, Gao, Zhe, Christopher Wittwer, Andrew M. Riley, Robin A. Felder, Amit Dutta, Chin, Alfred C., Semenza, Evan R., Potter, Barry V. L., Chin, Alfred, Snyder, Solomon H., Dorothea Fiedler, David Furkert, Jessen, Henning, Pluznick, Jennifer L., Zhe Gao, Felder, Robin A., Riley, Andrew, Tomas Rojas, Wittwer, Christopher, Riley, Andrew M., Evan R. Semenza, Rojas, Tomas   +32 more
core   +1 more source

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

Diabetes, Metabolic Syndrome and Obesity, 2014
Richard WA Mackenzie, Bradley T Elliott Department of Human and Health Sciences, Facility of Science and Technology, University of Westminster, London, UK Abstract: Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin ...
Mackenzie RWA, Elliott BT
doaj  

Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair

, 2013
Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are water-soluble inositol phosphates that contain high energy diphosphate moieties on the inositol ring.
Sengupta, Sagar, Jadav, Rathan S., Chanduri, Manasa V. L., Bhandari, Rashna   +3 more
core   +1 more source