Results 61 to 70 of about 573 (120)

Molecular mechanisms of perilipin protein function in lipid droplet metabolism

FEBS Letters, Volume 598, Issue 10, Page 1170-1198, May 2024.
Lipid droplets (LDs) are important for the storage of energy and lipid components. The perilipin family in mammals includes five proteins (PLIN1 to PLIN5), all of which are abundant on the surface of LDs in different tissues and play a role in LD stability and degradation by lipases.
Elena Griseti, Abdoul Akim Bello, Eric Bieth, Bayane Sabbagh, Jason S. Iacovoni, Joëlle Bigay, Henrik Laurell, Alenka Čopič   +7 more
wiley   +1 more source

The enzymes of human diphosphoinositol polyphosphate metabolism

The FEBS Journal, Volume 281, Issue 1, Page 14-33, January 2014., 2014
This review covers the three classes of enzymes involved in the metabolism of diphosphoinositol polyphosphates – inositol hexakisphosphate kinases (IP6K), inositol hexakisphosphate and diphosphoinositol‐pentakisphosphate kinases (PPIP5K), and diphosphoinositol polyphosphate phosphohydrolases (DIPP).
Mark P. Thomas, Barry V. L. Potter
wiley   +1 more source

Taenia solium cysticerci's extracellular vesicles Attenuate the AKT/mTORC1 pathway for Alleviating DSS‐induced colitis in a murine model

Journal of Extracellular Vesicles, Volume 13, Issue 5, May 2024.
Schematic description of AKT/mTORC1 pathway supression by Taenia solium derived EV particles on macrophages. Abstract The excretory–secretory proteome plays a pivotal role in both intercellular communication during disease progression and immune escape mechanisms of various pathogens including cestode parasites like Taenia solium.
Suraj Singh Rawat, Anand Kumar Keshri, Naina Arora, Rimanpreet Kaur, Amit Mishra, Rajiv Kumar, Amit Prasad   +6 more
wiley   +1 more source

Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction

Oxidative Medicine and Cellular Longevity, Volume 2014, Issue 1, 2014., 2014
Nitric oxide (NO) deficiency is involved in the development of hypertension, a condition that can originate early in life. We examined whether NO deficiency contributed to programmed hypertension in offspring from mothers with calorie‐restricted diets and whether melatonin therapy prevented this process.
You-Lin Tain, Li-Tung Huang, Chien-Ning Hsu, Chien-Te Lee, Jean-Claude Lavoie   +4 more
wiley   +1 more source

The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export [PDF]

Journal of Biological Chemistry, 2019
Phosphate's central role in most biochemical reactions in a living organism requires carefully maintained homeostasis. Although phosphate homeostasis in mammals has long been studied at the organismal level, the intracellular mechanisms controlling phosphate metabolism are not well-understood.
Miranda S. Wilson, Henning J. Jessen, Adolfo Saiardi   +2 more
openaire   +4 more sources

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

Diabetes, Metabolic Syndrome and Obesity, 2014
Richard WA Mackenzie, Bradley T Elliott Department of Human and Health Sciences, Facility of Science and Technology, University of Westminster, London, UK Abstract: Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin ...
Mackenzie RWA, Elliott BT
doaj  

Inhibition of Inositol hexakisphosphate Kinase 1 (IP6K1) Does Not Increase Akt or mTOR Activity in vitro .

The FASEB Journal, 2018
Background Inositol hexakisphosphate Kinase 1 (IP6K1) has been identified as a key signalling enzyme that inhibits Akt activity in hepatic cell lines and diabetic rodent models (Chakraborty et al., 2010; 2012; Goshal et al., 2016).
Richie Barclay, Richard Mackenzie
openaire   +1 more source

IP6K1 interacts with the syndecan SDC4 to support secretory granule biogenesis in gastric chief cells

American Journal of Physiology-Gastrointestinal and Liver Physiology
Inositol hexakisphosphate kinases (IP6Ks) catalyze the synthesis of the inositol pyrophosphate 5-InsP 7 , and regulate diverse physiological processes. Ip6k1 -/- mice display reduced body weight despite normal food intake, elevated fecal protein, and ...
Jayraj Sen, Pranjali Pore, Rashna Bhandari   +2 more
openaire   +1 more source

High‐intensity Interval Exercise decreases IP6K1 Muscle Content & Improves Insulin Sensitivity (S _I ^2* ) in Pre‐diabetic Individuals

The FASEB Journal, 2018
Insulin resistance in skeletal muscle contributes to whole body hyperglycaemia in pre‐diabetic and type 2 diabetic individuals. Insulin‐dependent glucose uptake in skeletal muscle requires the upregulation of the Akt‐AS160 signalling cascade (Bruss et al., 2005; Mackenzie & Elliott, 2014).
Jane Naufahu, Bradley Elliott, Oana Ancu, Fulvia Draicchio, Anatoliy Markiv, Nicholas M. Hurren, David Howard, Peter Watt, Richard W.A. Mackenzie   +8 more
openaire   +1 more source

Mammalian mitochondrial polyphosphate is regulated by the 5-InsP ₇ synthase IP6K1

Abstract Inorganic polyphosphate (polyP) is a linear polymer of varying length composed of phosphate residues linked by phosphoanhydride bonds. PolyP remains poorly understood in mammals due to its low abundance and lack of information on its synthesis and regulation. Using synthetic polyP 8
Jayashree S. Ladke, Azmi Khan, Anshit Singh, Jyoti Singh, Nicole Steck, Henning J. Jessen, Ullas Kolthur-Seetharam, Manish Jaiswal, Rashna Bhandari   +8 more
openaire   +1 more source