Results 61 to 70 of about 1,062 (145)
IP6K1 upregulates the formation of processing bodies by promoting proteome remodeling on the mRNA cap [PDF]
, 2020 AbstractInositol hexakisphosphate kinases (IP6Ks) are ubiquitously expressed small molecule kinases that catalyze the conversion of the inositol phosphate IP6 to 5-IP7. IP6Ks have been reported to influence cellular functions by protein-protein interactions independent of their enzymatic activity.
Akruti Shah, Rashna Bhandari
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The FASEB Journal, 2021 Phosphate (Pi) is an indispensable component of living organisms. In the body, Pi homeostasis is tightly regulated by four main tissues: intestine, kidney, bone and parathyroid glands. There are multiple complex mechanisms underlying the regulation of serum Pi including hormones and transporters.
Betül Haykir +3 more
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Frontiers in Physiology, 2020 Phytate forms insoluble precipitates with various cations that are recalcitrant to digestion in poultry. Dietary supplementation with exogenous phytase has been shown to improve phytate solubility and digestibility and, in turn, improve animal growth ...
Elizabeth Greene +4 more
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Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts [PDF]
, 2009 The polo-like kinases (Plks) are a group of serine/threonine kinases which have roles in many aspects of cellular function including the regulation of mitotic activity and cellular stress responses.
Alan Morettin +3 more
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Chemical tools to investigate inositol pyrophosphate protein interactions [PDF]
, 2023 Die Inositol-Pyrophosphate (PP-InsPs) sind eine ubiquitäre Gruppe hochphosphorylierter eukaryotischer Signalmoleküle. Sie werden mit einer Vielzahl zentraler zellulärer Prozesse in Verbindung gebracht, doch fehlt oft ein detailliertes Verständnis der ...
Furkert, David
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Scientific Reports, 2018 Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development.
Chenglai Fu +7 more
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Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair [PDF]
, 2012 Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are water-soluble inositol phosphates that contain high energy diphosphate moieties on the inositol ring.
Bhandari, Rashna +3 more
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IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids [PDF]
Journal of Cell Science, 2017 ABSTRACT Inositol hexakisphosphate kinases (IP6Ks) are enzymes that synthesise the inositol pyrophosphate 5-diphosphoinositol pentakisphosphate (5-IP7), which is known to regulate several physiological processes. Deletion of IP6K1, but not other IP6K isoforms, causes sterility in male mice.
Aushaq Bashir Malla, Rashna Bhandari
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Target of Rapamycin Complex 1 (TORC1), Protein Kinase A (PKA) and Cytosolic pH Regulate a Transcriptional Circuit for Lipid Droplet Formation [PDF]
, 2021 Lipid droplets (LDs) are ubiquitous organelles that fulfill essential roles in response to metabolic cues. The identification of several neutral lipid synthesizing and regulatory protein complexes have propelled significant advance on the mechanisms of ...
Costa, V +3 more
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Inositol pyrophosphates and Akt: Is the pancreatic β-cell the exception to the rule? [PDF]
, 2019 The inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), is thought to negatively regulate the critical insulin signaling protein Akt/PKB. Knock down of the IP7-generating inositol hexakisphosphate kinase 1 (IP6K1) results in a concomitant ...
RYU, SUNG HO
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