Results 21 to 30 of about 573 (120)

Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis [PDF]

Journal of Clinical Investigation, 2016
Enhancing energy expenditure (EE) is an attractive strategy to combat obesity and diabetes. Global deletion of Ip6k1 protects mice from diet-induced obesity (DIO) and insulin resistance, but the tissue-specific mechanism by which IP6K1 regulates body weight is unknown.
Qingzhang Zhu, Sarbani Ghoshal, Su Gao   +2 more
exaly   +3 more sources

Molecular modeling, dynamics simulation and characterization of human inositol hexakisphosphate kinase 1 (IP6K1) related to diabetes

Journal of Applied Sciences and Environmental Management, 2019
Inositol hexakisphosphate kinase-1 (IP6K1) protein plays an important role in insulin signaling producing IP7 that inhibit the action of protein kinase B (Akt).
O.O. Elekofehinti, Y.V. Aladenika, Y.R. Alli-Smith, O.C. Ejelonu, A.O. Lawal   +4 more
doaj   +3 more sources

Synthesis and characterization of novel isoform-selective IP6K1 inhibitors

Bioorganic and Medicinal Chemistry Letters, 2019
Inositol hexakisphosphate kinases (IP6Ks) have been increasingly studied as therapeutically interesting enzymes. IP6K isoform specific knock-outs have been used to successfully explore inositol pyrophosphate physiology and related pathologies. A pan-IP6K inhibitor, N2-(m-trifluorobenzyl)-N6-(p-nitrobenzyl) purine (TNP), has been used to confirm ...
Huijun Wei, James C Barrow
exaly   +4 more sources

Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport [PDF]

Biochemical Journal, 2016
Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are conserved eukaryotic signaling molecules that possess pyrophosphate and monophosphate moieties. Generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine pyrophosphorylation. Here,
Ashim Rai, Aushaq Bashir Malla, Mingxuan Wu   +2 more
exaly   +3 more sources

Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction. [PDF]

Int J Mol Sci, 2022
(1) Background: We previously demonstrated that disruption of IP6K1 improves metabolism, protecting mice from high-fat diet-induced obesity, insulin resistance, and non-alcoholic fatty liver disease and steatohepatitis. Age-induced metabolic dysfunction is a major risk factor for metabolic diseases. The involvement of IP6K1 in this process is unknown. (
Ghoshal S, Mukherjee S, Chakraborty M, Msengi EN, Haubner J, Chakraborty A.   +5 more
europepmc   +4 more sources

The relationship between vitamin D levels and depression: a genetically informed study [PDF]

Nutrition Journal
Background Low vitamin D (vitD) levels are consistently associated with an increased risk of depression. However, the biological mechanisms underlying this relationship and potential shared genetic overlap remain elusive.
Honggang Lyu, Lijun Kang, Qian Gong, Xin-Hui Xie, Simeng Ma, Lihua Yao, Mian-mian Chen, Lingfeng Zhang, Hao Yu, Xubo Wang, Chao Wang, Zhongchun Liu   +11 more
doaj   +2 more sources

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular Metabolism, 2016
Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty   +10 more
doaj   +3 more sources

Genome-wide association study reveals IP6K1 as a critical regulator of salinity tolerance in largemouth bass (Micropterus salmoides)

Aquaculture Reports
Given the increasing saturation of freshwater aquaculture space, saline-alkali aquaculture has become a critical strategy to expand fishery space. Largemouth bass (Micropterus salmoides) is an ideal candidate for saline-alkali aquaculture due to its ...
Jing Tian, Yang Liu, Shengjie Li, Zhu Zhu, Tao Zhu, Jinxing Du, Caixia Lei, Hongmei Song   +7 more
doaj   +2 more sources

Inositol hexakisphosphate kinase-1 (IP6K1) [PDF]

Science-Business EXchange, 2011
exaly   +2 more sources

Potential therapies targeting nuclear metabolic regulation in cancer

MedComm, Volume 4, Issue 6, December 2023., 2023
1. Cell metabolism and gene control are significantly integrated and regulated by one another. 2. There is a positive feedback loop of metabolism‐epigenetics‐gene regulation which control cancer progression. 3. The discovery of metabolic enzymes and their functions in the nucleus will provide more insights into cancer therapy.
Yanjie Chen, Jie Xu, Xiaoyi Liu, Linlin Guo, Ping Yi, Chunming Cheng   +5 more
wiley   +1 more source