Results 21 to 30 of about 1,062 (145)

Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets. [PDF]

Pediatr Res, 2023
BACKGROUND: Postnatal lean mass accretion is commonly reduced in preterm infants. This study investigated mechanisms involved in the blunted feeding-induced activation of Akt in the skeletal muscle of preterm pigs that contributes to lower protein ...
Suryawan A, Rudar M, Naberhuis JK, Fiorotto ML, Davis TA.   +4 more
europepmc   +3 more sources

β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner. [PDF]

Proc Natl Acad Sci U S A, 2023
Inositol pyrophosphates (PP-InsPs) are energetic signaling molecules with important functions in mammals. As their biosynthesis depends on ATP concentration, PP-InsPs are tightly connected to cellular energy homeostasis.
Eisenbeis VB, Qiu D, Gorka O, Strotmann L, Liu G, Prucker I, Su XB, Wilson MSC, Ritter K, Loenarz C, Groß O, Saiardi A, Jessen HJ.   +12 more
europepmc   +3 more sources

The relationship between vitamin D levels and depression: a genetically informed study [PDF]

Nutrition Journal
Background Low vitamin D (vitD) levels are consistently associated with an increased risk of depression. However, the biological mechanisms underlying this relationship and potential shared genetic overlap remain elusive.
Honggang Lyu, Lijun Kang, Qian Gong, Xin-Hui Xie, Simeng Ma, Lihua Yao, Mian-mian Chen, Lingfeng Zhang, Hao Yu, Xubo Wang, Chao Wang, Zhongchun Liu   +11 more
doaj   +2 more sources

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular Metabolism, 2016
Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty   +10 more
doaj   +3 more sources

XPR1: a regulator of cellular phosphate homeostasis rather than a Pi exporter. [PDF]

Pflugers Arch
\ua9 The Author(s) 2024. Phosphate (Pi) is an essential nutrient, and its plasma levels are under tight hormonal control. Uphill transport of Pi into cells is mediated by the two Na-dependent Pi transporter families SLC34 and SLC20.
Burns D, Berlinguer-Palmini R, Werner A.
europepmc   +3 more sources

Platelet IP6K1 regulates neutrophil extracellular trap–microparticle complex formation in acute pancreatitis [PDF]

JCI Insight, 2021
Platelet inositol hexakisphosphate kinase 1 (IP6K1) has been shown to control systemic inflammation. Herein, we examined if platelets and IP6K1 regulate pancreatic tissue injury via formation of NETs in experimental models of acute pancreatitis (AP) in mice.
Raeh Madhi, Milladur Rahman, Dler Taha, Johan Linders, Mohammed Merza, Yongzhi Wang, Matthias Mörgelon, Henrik Thorlacius   +7 more
doaj   +7 more sources

Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-InsP7. [PDF]

Biosci Rep, 2023
AbstractInositol pyrophosphates (PP-IPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-IPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser. This unique post-translational modification occurs on Ser residues that lie in acidic stretches within
Hamid A, Ladke JS, Shah A, Ganguli S, Pal M, Singh A, Bhandari R.   +6 more
europepmc   +3 more sources

Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase. [PDF]

J Biol Chem, 2022
ABSTRACTInositol is an essential metabolite that serves as a precursor for structural and signaling molecules. Although perturbation of inositol homeostasis has been implicated in numerous human disorders, surprisingly little is known about how inositol levels are regulated in mammalian cells.
Lazcano P, Schmidtke MW, Onu CJ, Greenberg ML.   +3 more
europepmc   +4 more sources

The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function. [PDF]

J Am Soc Nephrol
Significance Statement Kidneys are gatekeepers of systemic inorganic phosphate balance because they control urinary phosphate excretion. In yeast and plants, inositol hexakisphosphate kinases (IP6Ks) are central to regulate phosphate metabolism, whereas their role in mammalian phosphate homeostasis is mostly unknown.
Haykir B, Moser SO, Pastor-Arroyo EM, Schnitzbauer U, Radvanyi Z, Prucker I, Qiu D, Fiedler D, Fiedler D, Saiardi A, Jessen HJ, Hernando N, Wagner CA.   +12 more
europepmc   +5 more sources

Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction. [PDF]

Int J Mol Sci, 2022
(1) Background: We previously demonstrated that disruption of IP6K1 improves metabolism, protecting mice from high-fat diet-induced obesity, insulin resistance, and non-alcoholic fatty liver disease and steatohepatitis. Age-induced metabolic dysfunction is a major risk factor for metabolic diseases. The involvement of IP6K1 in this process is unknown. (
Ghoshal S, Mukherjee S, Chakraborty M, Msengi EN, Haubner J, Chakraborty A.   +5 more
europepmc   +4 more sources