Results 21 to 30 of about 737 (136)
Molecules, 2021 IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao +5 more
doaj +2 more sources
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee +2 more
doaj +2 more sources
The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export [PDF]
Journal of Biological Chemistry, 2019 Phosphate's central role in most biochemical reactions in a living organism requires carefully maintained homeostasis. Although phosphate homeostasis in mammals has long been studied at the organismal level, the intracellular mechanisms controlling phosphate metabolism are not well-understood.
Miranda S. Wilson +2 more
core +8 more sources
Scientific Reports, 2018 Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development.
Chenglai Fu +7 more
doaj +2 more sources
The relationship between vitamin D levels and depression: a genetically informed study [PDF]
Nutrition JournalBackground Low vitamin D (vitD) levels are consistently associated with an increased risk of depression. However, the biological mechanisms underlying this relationship and potential shared genetic overlap remain elusive.
Honggang Lyu +11 more
doaj +2 more sources
Aquaculture ReportsGiven the increasing saturation of freshwater aquaculture space, saline-alkali aquaculture has become a critical strategy to expand fishery space. Largemouth bass (Micropterus salmoides) is an ideal candidate for saline-alkali aquaculture due to its ...
Jing Tian +7 more
doaj +2 more sources
Inositol pyrophosphate kinases in health and disease. [PDF]
FEBS LettIn mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Xing C +6 more
europepmc +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates - detection, function, and regulation. [PDF]
FEBS LettProtein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Lampe S +3 more
europepmc +2 more sources
Platelet IP6K1 regulates neutrophil extracellular trap–microparticle complex formation in acute pancreatitis [PDF]
JCI Insight, 2021 Platelet inositol hexakisphosphate kinase 1 (IP6K1) has been shown to control systemic inflammation. Herein, we examined if platelets and IP6K1 regulate pancreatic tissue injury via formation of NETs in experimental models of acute pancreatitis (AP) in mice.
Raeh Madhi +7 more
doaj +7 more sources
Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling. [PDF]
Biomed Pharmacother, 2023 The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the mechanisms of action have been elusive. Here we report that itraconazole disrupts focal adhesion dynamics and cytoskeletal remodeling, which requires 5 ...
Qi J +10 more
europepmc +2 more sources