Key Aspects of Myo-Inositol Hexaphosphate (Phytate) and Pathological Calcifications. [PDF]
Molecules, 2019 Phytate (myo-inositol hexaphosphate, InsP6) is an important component of seeds, legumes, nuts, and whole cereals. Although this molecule was discovered in 1855, its biological effects as an antinutrient was first described in 1940. The antinutrient effect of phytate results because it can decrease the bioavailability of important minerals under certain
Grases F, Costa-Bauza A.
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Inositol hexaphosphate-induced cellular response in myeloid leukemia cells is mediated by nicotinamide adenine dinucleotide phosphate oxidase activation [PDF]
Fujita Medical Journal, 2019 Objectives: The objective of this study was to identify the role of reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, in inositol hexaphosphate (IP6)-induced metabolic disruption in human leukemia PLB-
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Onset of the lymphocytic infiltration and hyperplasia preceding the proliferation in F1 mouse lungs from the N-ethyl-N-nitrosourea exposed mothers: Prevention during the lactation period by inositol hexaphosphate [PDF]
Toxicology Reports, 2015 Maternal exposure to a carcinogen is associated with increased risk of different cancers in the offspring. The foetus is highly sensitive to carcinogens and this contributes to the foetal basis of the onset of disease.
Satya Sahay +2 more
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The interaction of inositol hexaphosphate with methaemoglobin [PDF]
Biochemical Journal, 1973 1. Inositol hexaphosphate causes the shape of the oxidation–reduction equilibrium curve to become hyberbolic at acid pH values. 2. Inositol hexaphosphate also causes a decrease in the alkaline oxidation Bohr effect at these same pH values. 3.
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IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise [PDF]
BiomoleculesInositol hexaphosphate (IP6), also known as phytic acid, has historically been classified as an antinutrient due to its mineral-chelating properties, which were believed to impair nutrient absorption.
Alissa Saverino +2 more
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Sorption of inositol hexaphosphate on desert soils
Geoderma, 2014 Abstract Sorption of inositol hexaphosphate (IP6) on desert soils was studied to evaluate their use as a novel low-cost sorbent material for organic P removal in water treatment. The kinetics of IP6 sorption, pH effects, and sorption isotherms were examined in batch experiments on four desert saline–sodic soils: Antofagasta (AN), Mejillones (ME ...
Fuentes, Barbara +5 more
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Differential Influence of Inositol Hexaphosphate on the Expression of Genes Encoding TGF-β Isoforms and Their Receptors in Intestinal Epithelial Cells Stimulated with Proinflammatory Agents [PDF]
Mediators of Inflammation, 2013 Transforming growth factor β (TGF-β) is a multifunctional cytokine recognized as an important regulator of inflammatory responses. The effect of inositol hexaphosphate (IP6), a naturally occurring phytochemical, on the mRNA expression of TGF-β1, TGF-β2 ...
Małgorzata Kapral +3 more
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Neoplasia: An International Journal for Oncology Research, 2004 Prostate cancer (PCA) is the most common invasive malignancy and the second leading cause of cancerrelated deaths in the US male population. One approach to control this malignancy is its preventive intervention by dietary agents. Inositol hexaphosphate (
Chapla Agarwal +3 more
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Effects of Inositol Hexaphosphate and Myo-Inositol Administration in Breast Cancer Patients during Adjuvant Chemotherapy. [PDF]
J Pers Med, 2021 Amabile MI +10 more
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Age-Dependent Histone Deacetylase 3 Regulation by βA3/A1-Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age-Related Macular Degeneration. [PDF]
Aging CellβA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Chatterjee S +16 more
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