Results 41 to 50 of about 2,051 (135)

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, Volume 38, Issue 3, 13 January 2026.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Effects of Corn Fermented Protein as a Primary Protein Source on Growth Performance, Feed Utilization Efficiency, Hemolymph Biochemical Parameters, and Physiological and Digestive Gene Expression of Pacific White Shrimp (Litopenaeus vannamei)

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
This study aimed to determine the effect of replacing fish meal (FM), soybean meal (SBM), and corn protein concentrate (CPC) in an equal ratio with corn fermented protein (CFP) on Pacific white shrimp, Litopenaeus vannamei growth, feed utilization efficiency, hemolymph parameters, and physiological gene expression.
Khanh Q. Nguyen, Cristhian San Andres, Adela N. Araujo, Trenton L. Corby, Melanie A. Rhodes, Scott Tilton, Timothy J. Bruce, D. Allen Davis, Liqiao Chen   +8 more
wiley   +1 more source

Inositol Polyphosphate 5-Phosphatases 1 and 2 Are Required for Regulating Seedling Growth

Plant Physiology, 2007
Abstract Signals can be perceived and amplified at the cell membrane by receptors coupled to the production of a variety of second messengers, including myoinositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. The myoinositol polyphosphate 5-phosphatases (5PTases; EC 3.1.3.56) comprise a large protein family that hydrolyzes 5-phosphates from a ...
Bhadra, Gunesekera, Javad, Torabinejad, Jamille, Robinson, Glenda E, Gillaspy   +3 more
openaire   +2 more sources

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
wiley   +1 more source

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source

Signaling Inositol Polyphosphate-5-phosphatase [PDF]

Journal of Biological Chemistry, 1997
Anne Bennett Jefferson, Vorachart Auethavekiat, David A. Pot, Lewis T. Williams, Philip W. Majerus   +4 more
openaire   +1 more source

Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.

Cell, 2001
Inositol polyphosphate 5-phosphatases are central to intracellular processes ranging from membrane trafficking to Ca(2+) signaling, and defects in this activity result in the human disease Lowe syndrome. The 1.8 resolution structure of the inositol polyphosphate 5-phosphatase domain of SPsynaptojanin bound to Ca(2+) and inositol (1,4)-bisphosphate ...
Tsujishita, Yosuke, Guo, Shuling, Stolz, Leslie E., York, John D., Hurley, James H.   +4 more
openaire   +2 more sources

Inositol polyphosphate-5-phosphatase (INPP5D; SHIP) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Distinct Membrane and Cytosolic Forms of Inositol Polyphosphate 5-Phosphatase II [PDF]

Journal of Biological Chemistry, 1998
Maria Matzaris, Cindy J. O'Malley, Anne Badger, Caroline J. Speed, Phillip I. Bird, Christina. A. Mitchell   +5 more
openaire   +1 more source