Results 21 to 30 of about 2,051 (135)

Regulation of phosphoinositide signaling by the inositol polyphosphate 5‐phosphatases [PDF]

IUBMB Life, 2006
AbstractPhosphoinositide signaling molecules control cellular growth, proliferation and differentiation, intracellular vesicle trafficking, and cytoskeletal rearrangement. The inositol polyphosphate 5‐phosphatase family remove the D‐5 position phosphate from PtdIns(3,4,5)P3, PtdIns(4,5)P2 and PtdIns(3,5)P2 forming PtdIns(3,4)P2, PtdIns(4)P and PtdIns(3)
Megan V, Astle, Gillian, Seaton, Elizabeth M, Davies, Clare G, Fedele, Parvin, Rahman, Laima, Arsala, Christina A, Mitchell   +6 more
openaire   +2 more sources

Membrane Interaction and Functional Plasticity of Inositol Polyphosphate 5-Phosphatases [PDF]

Structure, 2014
In this issue of Structure, Trésaugues and colleagues determined the interaction of membrane-bound phosphoinositides with three clinically significant human inositol polyphosphate 5-phosphatases (I5Ps). A comparison to the structures determined with soluble substrates revealed differences in the binding mode and suggested how the I5Ps and apurinic ...
Braun, Werner, Schein, Catherine H.
openaire   +2 more sources

Frequent loss of inositol polyphosphate‐5‐phosphatase in oropharyngeal squamous cell carcinoma [PDF]

Journal of the European Academy of Dermatology and Venereology, 2017
There is an incomplete understanding in the pathogenesis of oropharyngeal squamous cell carcinoma (OPSCC) and cancer broadly. It is essential to discover new pathways of normal cell-cycle regulation and oncogenesis. We identified that the loss of inositol polyphosphate-5-phosphatase (INPP5A) may play a role in the development and progression of ...
A B, Patel, A R, Mangold, C M, Costello, T H, Nagel, M L, Smith, R E, Hayden, A, Sekulic   +6 more
openaire   +2 more sources

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. [PDF]

Genes & Development, 1996
The production, survival, and function of monocytes and macrophages is regulated by the macrophage colony-stimulating factor (M-CSF or CSF-1) through its tyrosine kinase receptor Fms. Binding of M-CSF to Fms induces the tyrosine phosphorylation and association of a 150-kD protein with the phosphotyrosine-binding (PTB) domain of Shc. We have cloned p150
M N, Lioubin, P A, Algate, S, Tsai, K, Carlberg, A, Aebersold, L R, Rohrschneider   +5 more
openaire   +2 more sources

Tissue Distribution and Intracellular Localisation of the 75‐kDa Inositol Polyphosphate 5‐Phosphatase [PDF]

European Journal of Biochemistry, 1995
The 75‐kDa inositol polyphosphate 5‐phosphatase (75‐kDa 5‐phosphatase) hydrolyses several important mediators of intracellular calcium homeostasis, including inositol 1,4,5‐trisphosphate [Ins(1,4,5)P3], inositol 1,3,4,5‐tetrakisphosphate [Ins(1,3,4,5)P4] and phosphatidylinositol 4,5‐bisphosphate [PtdIns(4,5)P2].Northern analysis of various human ...
C J, Speed, M, Matzaris, P I, Bird, C A, Mitchell   +3 more
openaire   +2 more sources

Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity [PDF]

Scientific Reports, 2014
AbstractGlioblastoma (GBM), the most common type of primary malignant brain tumors harboring a subpopulation of stem-like cells (GSCs), is a fast-growing and often fatal tumor. Signal Transducer and Activator of Transcription 3 (STAT3) is one of the major signaling pathways in GSCs maintenance but the molecular mechanisms underlying STAT3 deregulation ...
Hong Sug Kim, Aiguo Li, Susie Ahn, Hua Song, Wei Zhang   +4 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

The FEBS Journal, EarlyView.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia, Jiwang Tang, José C. Casas‐Martinez, Penglin Li, Maria Borja‐Gonzalez, Leo R Quinlan, Katarzyna Goljanek‐Whysall, Brian McDonagh   +7 more
wiley   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source