Results 1 to 10 of about 2,051 (135)

Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer [PDF]

Communications Biology
Phosphoinositide 3-kinase (PI3K) signaling is hyperactivated in ~70% of breast cancers via mutations in oncogenes including PIK3CA or inactivation/depletion of phosphoinositide (PI)-phosphatases.
Lisa M. Ooms, Daniel T. Ferguson, Samuel J. Rodgers, Karmanpreet K. Sukhija, Emily I. Jones, Mariah P. Csolle, Hon Yan Kelvin Yip, Roger J. Daly, Tony Tiganis, Catriona A. McLean, Antonella Papa, Christina A. Mitchell   +11 more
doaj   +2 more sources

The PKA/MBD2 Axis Transcriptionally Represses INPP5A to Modulate PI3K/Akt Signaling and Accelerate Pituitary Tumorigenesis. [PDF]

CNS Neurosci Ther
Loss of INPP5A in PitNETs disrupts IP3 clearance and drives aberrant PI3K/Akt activation. PKA‐dependent phosphorylation stabilizes MBD2 via 14‐3‐3σ, sustaining transcriptional silencing of INPP5A. MBD2 inhibition sensitizes tumors to standard treatments and limits PitNET growth.
Jiang Q, Wang Y, Wang Z, Wang Q, Li S, Xu L, Zhang Z, Tan Z, Zhang H, Shu K, Lei T, Huang Y, Lei Z.   +12 more
europepmc   +2 more sources

Gap Analysis of Metabolic Conversions of Off-Flavors and Antinutrients in Plant-Based Substrates. [PDF]

Compr Rev Food Sci Food Saf
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Kuijpers RI, de Moya Clark IO, Cavaco T, Nemanič V, Tagliabue B, Valero-Abad A, Wennekers WM, Zhang M, Van Zwet K, Abeln S, Moco S, Paul CE, Mouhib H, Notebaart RA, Smid EJ, Teusink B, Bachmann H.   +16 more
europepmc   +2 more sources

Computational Evaluation of Designed Phosphatase from Conserved Sequence Scratch for Diverse Substrate Specificity [PDF]

International Journal Bioautomation, 2022
The ability to design efficient enzymes for a broad class of different reactions would be of tremendous practical interest in both science and industry. Computer-assisted designing is a novel approach to generating industrial enzymes for biotechnological
Paulchamy Chellapandi, Jayachandrabal Balachandramohan   +1 more
doaj   +1 more source

Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone

Frontiers in Cell and Developmental Biology, 2021
Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment of ...
Sarah E. Conduit, Elizabeth M. Davies, Alex J. Fulcher, Viola Oorschot, Christina A. Mitchell   +4 more
doaj   +1 more source

Alteration of the N6-methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome

Journal of Ovarian Research, 2023
Objective To explore the N6-methyladenosine (m6A) methylation abnormality of mRNAs and its potential roles in the mouse model of polycystic ovary syndrome (PCOS).
Lingxiao Zou, Waixing Li, Dabao Xu, Shujuan Zhu, Bin Jiang   +4 more
doaj   +1 more source

The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease

Journal of Lipid Research, 2019
Phosphoinositides (PIs) are recognized as major signaling molecules in many different functions of eukaryotic cells. PIs can be dephosphorylated by multiple phosphatase activities at the 5-, 4-, and 3- positions.
Ana Raquel Ramos, Somadri Ghosh, Christophe Erneux   +2 more
doaj   +1 more source

Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleases

BMC Bioinformatics, 2002
Background Total sequence decomposition, using the web-based MASIA tool, identifies areas of conservation in aligned protein sequences. By structurally annotating these motifs, the sequence can be parsed into individual building blocks, molecular legos ("
Braun Werner, Izumi Tadahide, Özgün Numan, Schein Catherine H   +3 more
doaj   +1 more source

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.

PLoS ONE, 2013
Inositol phosphatases are important regulators of cell signaling, polarity, and vesicular trafficking. Mutations in OCRL, an inositol polyphosphate 5-phosphatase, result in Oculocerebrorenal syndrome of Lowe, an X-linked recessive disorder that presents ...
Na Luo, Akhilesh Kumar, Michael Conwell, Robert N Weinreb, Ryan Anderson, Yang Sun   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source