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Inotropic Effects of Ranitidine
Survey of Anesthesiology, 1990The purpose of this controlled study was to study the effect of cimetidine and ranitidine on the myocardium of 8 healthy male volunteers using systolic time intervals. Ranitidine caused a significant decrease in the QS2I, as from 40 min indicating a positive inotropic effect. There were no significant changes in heart-rate or blood-pressure.
M. van Wyk +3 more
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Annual Review of Pharmacology and Toxicology, 1984
A large number of naturally occurring and synthetically prepared chemical agents produce a positive inotropic effect on the heart. Analogues of these compounds have been isolated, prepared, and tested, and a number of them also have positive inotropic effects (see Tables 1-6).
R P Schwarz, and A A Alousi, A.E. Farah
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A large number of naturally occurring and synthetically prepared chemical agents produce a positive inotropic effect on the heart. Analogues of these compounds have been isolated, prepared, and tested, and a number of them also have positive inotropic effects (see Tables 1-6).
R P Schwarz, and A A Alousi, A.E. Farah
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Intensive and Critical Care Nursing, 1992
It is essential that nurses understand the drugs they are using, and the measurements they are monitoring. Inotropes are powerful drugs with immediate action. The aim of this article is to give an overview of the inotropes used commonly in intensive care environments, plus some of those currently undergoing investigation.
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It is essential that nurses understand the drugs they are using, and the measurements they are monitoring. Inotropes are powerful drugs with immediate action. The aim of this article is to give an overview of the inotropes used commonly in intensive care environments, plus some of those currently undergoing investigation.
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Vasopressors and Inotropes in Sepsis
Emergency Medicine Clinics of North America, 2017Vasopressor and inotropes are beneficial in shock states. Norepinephrine is considered the first-line vasopressor for patients with sepsis-associated hypotension. Dobutamine is considered the first-line inotrope in sepsis, and should be considered for patients with evidence of myocardial dysfunction or ongoing signs of hypoperfusion.
Leeanne Stratton +2 more
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Positive inotropic stimulation
Current Opinion in Critical Care, 2002Adrenergic receptors transduce signals through the G proteins to regulate cardiac function. The catecholamines, via alpha- and beta-adrenergic receptor (beta-AR) stimulation, may play a role in the development of heart failure. Norepinephrine and isoproterenol can induce cardiac myocyte apoptosis.
Marc Leone +2 more
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2018
Vasopressors and inotropes are used in the neurosciences intensive care unit to treat hypotension and to augment blood pressure. Hypotension can be attributed to abnormal cardiac output, abnormal intravascular volume or abnormal systemic vascular resistance.
Eelco F. M. Wijdicks, Sarah L. Clark
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Vasopressors and inotropes are used in the neurosciences intensive care unit to treat hypotension and to augment blood pressure. Hypotension can be attributed to abnormal cardiac output, abnormal intravascular volume or abnormal systemic vascular resistance.
Eelco F. M. Wijdicks, Sarah L. Clark
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Pediatric Emergency Care, 2018
Abstract Sepsis, severe sepsis, and septic shock represent a dynamic clinical syndrome involving a systemic inflammatory response, circulatory changes, and end-organ dysfunction from an infection. Early aggressive management to restore perfusion and/or improve hypotension is critical to improving outcomes.
Lori Rutman, Drew Taylor Louden
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Abstract Sepsis, severe sepsis, and septic shock represent a dynamic clinical syndrome involving a systemic inflammatory response, circulatory changes, and end-organ dysfunction from an infection. Early aggressive management to restore perfusion and/or improve hypotension is critical to improving outcomes.
Lori Rutman, Drew Taylor Louden
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Clinics in Perinatology, 2020
Primary function of cardiovascular system is to meet body's metabolic demands. The aim of inotrope therapy is to minimise adverse impact of cardiovascular compromise. Current use of inotropes is primarily guided by the pathophysiology of cardiovascular compromise and anticipated actions of inotropes.
Koert de Waal +3 more
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Primary function of cardiovascular system is to meet body's metabolic demands. The aim of inotrope therapy is to minimise adverse impact of cardiovascular compromise. Current use of inotropes is primarily guided by the pathophysiology of cardiovascular compromise and anticipated actions of inotropes.
Koert de Waal +3 more
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Inotropic actions of eicosanoids
Basic Research in Cardiology, 1992Eicosanoids (prostaglandins, leukotrienes, thromboxane A2 and other metabolites of C-20 polyunsaturated fatty acids) have numerous effects in the cardiovascular system. Direct inotropic actions have been repeatedly described, but appear in only very few cases to be due to direct modification of the inotropic state of the heart.
Karsten Schrör, Th. Hohlfeld
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Anaesthesia & Intensive Care Medicine, 2021
Shailendra K. Motwani, Helen Saunders
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Shailendra K. Motwani, Helen Saunders
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