Results 31 to 40 of about 18,354 (276)

Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline

Pharmacology Research & Perspectives, 2021
Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically ...
Alexander Dashwood, Elizabeth Cheesman, Yee Weng Wong, Haris Haqqani, Nicole Beard, Karen Hay, Melanie Spratt, Wandy Chan, Peter Molenaar   +8 more
doaj   +1 more source

Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients The ROADMAP Study 2-Year Results [PDF]

, 2017
OBJECTIVES The authors sought to provide the pre-specified primary endpoint of the ROADMAP (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients) trial at 2 years ...
Boyle, Andrew J., Bruckner, Brian A., Chuang, Joyce, Estep, Jerry D., Farrar, David J., Haas, Donald C., Horstmanshof, Douglas A., Kasirajan, Vigneshwar, Lee, Sangjin, Long, James W., Milano, Carmelo A., Rogers, Joseph G., Selzman, Craig H., Shah, Keyur B., Starling, Randall C., Stehlik, Josef   +15 more
core   +2 more sources

Levosimendan for the prevention of acute organ dysfunction in sepsis [PDF]

, 2016
BACKGROUND Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients with sepsis. METHODS We conducted a double-blind, randomized clinical trial to investigate whether levosimendan reduces the ...
Al-Beidh, F, Ashby, D, Best-Lane, J, Brealey, D, Breen, A, Cross, M, Gordon, AC, Liu, KD, Mason, AJ, McAuley, DF, McNamee, JJ, Nutt, CL, Orme, RML, Perkins, GD, Reschreiter, H, Santhakumaran, S, Singer, M   +16 more
core   +2 more sources

Levosimendan for patients with severely reduced left ventricular systolic function and/or low cardiac output syndrome undergoing cardiac surgery. a systematic review and meta-analysis [PDF]

, 2017
Background: Previous studies have shown beneficial effects of levosimendan in high-risk patients undergoing cardiac surgery. Two large randomized controlled trials (RCTs), however, showed no advantages of levosimendan.
Arcadipane, Antonio, Knight, Joshua B., Lorini, Ferdinando L., Morelli, Andrea, Pastore, Federico, Sanfilippo, Filippo, Santonocito, Cristina, Scolletta, Sabino, Tritapepe, Luigi   +8 more
core   +2 more sources

Vasopressors and inotropes in cardiogenic shock patients: an analysis of the MIMIC-IV database

Frontiers in Cardiovascular Medicine, 2023
IntroductionPharmacological support has become the mainstay therapy in patients with cardiogenic shock (CS). Unfortunately, the clinical benefits of such potent drugs remain unclear, therefore, the present study aims to elucidate the safety and efficacy ...
Bryan Richard Sasmita, ChuanYing Wang, Siyuan Xie   +2 more
doaj   +1 more source

Multicenter Validation of the Vasoactive-Ventilation-Renal Score as a Predictor of Prolonged Mechanical Ventilation After Neonatal Cardiac Surgery [PDF]

, 2018
Objectives: We sought to validate the Vasoactive-Ventilation-Renal score, a novel disease severity index, as a predictor of outcome in a multicenter cohort of neonates who underwent cardiac surgery. Design: Retrospective chart review.
Cashen, Katherine, Costello, John M., Gowda, Keshava Murty Narayana, Grimaldi, Lisa M., Mastropietro, Christopher W., Moser, Elizabeth A. S., Piggott, Kurt D., Wilhelm, Michael   +7 more
core   +1 more source

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Cerebral autoregulation, brain injury, and the transitioning premature infant [PDF]

, 2017
Improvements in clinical management of the preterm infant have reduced the rates of the two most common forms of brain injury, such as severe intraventricular hemorrhage and white matter injury, both of which are contributory factors in the development ...
Mathur, Amit M, Vesoulis, Zachary A
core   +3 more sources

Barriers to enrollment in a randomized controlled trial of hydrocortisone for cardiovascular insufficiency in term and late preterm newborn infants. [PDF]

, 2017
ObjectiveTo analyze reasons for low enrollment in a randomized controlled trial (RCT) of the effect of hydrocortisone for cardiovascular insufficiency on survival without neurodevelopmental impairment (NDI) in term/late preterm newborns.Study designThe ...
A Das, A F Duncan, B B Poindexter, B Carper, B J Stoll, C B Lacy, C Gauldin, C M Cotten, E F Bell, E Fernandez, G M Sokol, K A Kennedy, K L Watterberg, K P Van Meurs, M C Walsh, M H Wyckoff, M V Fraga, null null, P J Sanchez, R D Higgins, S Chawla, S Lakshminrusimha, S S Beauman, U Devaskar, W A Carlo, W E Truog, W F Buss   +26 more
core   +1 more source

Long‐term safety of intravenous cardiovascular agents in acute heart failure: results from the European Society of Cardiology Heart Failure Long‐Term Registry [PDF]

, 2017
[Abstract] Aims. The aim of this study was to assess long‐term safety of intravenous cardiovascular agents—vasodilators, inotropes and/or vasopressors—in acute heart failure (AHF). Methods and results.
Aldo P. Maggioni, Alexandre Mebazaa, Cecile Laroche, Eiichi Akiyama, Etienne Gayat, Eulalia Roig, Frank Ruschitzka, Gerasimos Filippatos, Justina Motiejunaite, Lars H. Lund, Maria G. Crespo-Leiro, Marisa Sanz Julve, null null, Ovidiu Chioncel, Petar Seferovic, Veli-Pekka Harjola   +15 more
core   +2 more sources