Results 31 to 40 of about 29,730 (250)

Paediatrics: how to manage septic shock

Drugs in Context, 2021
Background: Septic shock is a common critical illness associated with high morbidity and mortality in children. This article provides an updated narrative review on the management of septic shock in paediatric practice.
Kam Lun Hon, Karen Ka Yan Leung, Felix Oberender, Alexander KC Leung   +3 more
doaj   +1 more source

Awareness and knowledge of intra-abdominal hypertension and abdominal compartment syndrome: results of an international survey [PDF]

, 2014
Background: Surveys have demonstrated a lack of physician awareness of intra-abdominal hypertension and abdominal compartment syndrome (IAH/ACS) and wide variations in the management of these conditions, with many intensive care units (ICUs) reporting ...
De Keulenaer, Bart L, De laet, Inneke, De Waele, Jan, Debergh, Dieter, Kirkpatrick, Andrew W, Malbrain, Manu LNG, Roberts, Derek J, Vandervelden, Stefanie, Wise, Robert   +8 more
core   +1 more source

Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) [PDF]

, 2012
Introduction: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in ...
Barnett, A. H., Cooke, Matthew, Hawkey, P. M., Hong, Tan, Jones, Alan, Linhartova, Lucie, Melody, Teresa, Patel, Jaimin M., Perkins, Gavin D., Smith, F. Gao, Snaith, Catherine, Thickett, David R.   +11 more
core   +3 more sources

Functional status in ICU survivors and out of hospital outcomes: a cohort study [PDF]

, 2016
OBJECTIVES: Functional status at hospital discharge may be a risk factor for adverse events among survivors of critical illness. We sought to examine the association between functional status at hospital discharge in survivors of critical care and risk ...
Amrein, Karin, Christopher, Kenneth B., Horkan, Clare M., Mogensen, Kris M., Quraishi, Sadeq A., Rydingsward, Jessica E.   +5 more
core   +1 more source

Barriers to enrollment in a randomized controlled trial of hydrocortisone for cardiovascular insufficiency in term and late preterm newborn infants. [PDF]

, 2017
ObjectiveTo analyze reasons for low enrollment in a randomized controlled trial (RCT) of the effect of hydrocortisone for cardiovascular insufficiency on survival without neurodevelopmental impairment (NDI) in term/late preterm newborns.Study designThe ...
A Das, A F Duncan, B B Poindexter, B Carper, B J Stoll, C B Lacy, C Gauldin, C M Cotten, E F Bell, E Fernandez, G M Sokol, K A Kennedy, K L Watterberg, K P Van Meurs, M C Walsh, M H Wyckoff, M V Fraga, null null, P J Sanchez, R D Higgins, S Chawla, S Lakshminrusimha, S S Beauman, U Devaskar, W A Carlo, W E Truog, W F Buss   +26 more
core   +1 more source

Pre-operative optimisation employing dopexamine or adrenaline for patients undergoing major elective surgery: a cost-effectiveness analysis [PDF]

, 2002
<b>Objective</b>: To compare the cost and cost-effectiveness of a policy of pre-operative optimisation of oxygen delivery (using either adrenaline or dopexamine) to reduce the risk associated with major elective surgery, in high-risk patients.
Claxton, K., Fenwick, E., Sculpher, M.J., Wilson, J.   +3 more
core   +1 more source

Advanced cardiovascular support in refractory shock

Indian Journal of Respiratory Care, 2018
“Shock” is a term that is used to signify inadequate tissue perfusion and cellular oxygenation. The basic principle of treating shock is restoring tissue perfusion and adequate cellular oxygenation.
Ashwin Neelavar Udupa, Rajesh Mohan Shetty   +1 more
doaj   +1 more source

Extended‐Release Oral Milrinone for the Treatment of Heart Failure With Preserved Ejection Fraction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent form of heart failure, representing half of the total burden of heart failure. We hypothesised that modulation of the phosphodiesterase type 3/cyclic AMP using
Shane Nanayakkara, Melissa Byrne, Vivian Mak, Kaye Carter, Eliza Dean, David M. Kaye   +5 more
doaj   +1 more source

Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials. [PDF]

, 2019
Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion.
Ahmad, T, Allen, LA, Böhm, M, Desai, NR, Lindenfeld, J, McCullough, M, Miller, PE, Psotka, M, Riello, R, Rosano, GMC, Teerlink, JR   +10 more
core   +2 more sources

Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery. [PDF]

, 2012
BACKGROUND: Intraoperative fluid therapy regimens using oesophageal Doppler monitoring (ODM) to optimize stroke volume (SV) (goal-directed fluid therapy, GDT) have been associated with a reduction in length of stay (LOS) and complication rates after ...
Abbas, Bellamy, Brandstrup, Brunkhorst, Bundgaard-Nielsen, Bundgaard-Nielsen, C. Challand, Davies, Dindo, Faiz, Futier, G. Minto, Gan, Giglio, Grocott, Hollowell, J.R. Sneyd, K.B. Hosie, Kehlet, Lees, Lobo, Mills, N. Mellor, Noblett, Older, P.D. Erasmus, Pearse, Powell-Tuck, R. Struthers, Roche, Sanders, Schortgen, Senagore, Shoemaker, Shoemaker, Snowden, Wakeling, Walsh, Wilson   +38 more
core   +2 more sources